Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease

Shiro Koh; Hideo Koh; Yasuhiro Nakashima; Takako Katayama; Manami Sakabe; Hiroshi Okamura; Takuro Yoshimura; Satoru Nanno; Mitsutaka Nishimoto; Yoshiki Hayashi; Takahiko Nakane; Hirohisa Nakamae; Masahiko Ohsawa; Masayuki Hino

doi:10.2169/internalmedicine.55.6206

CASE REPORTS

Plasma Kinetics of Th1, Th2 and Th17 Cytokines in Polymyositis Related to Chronic Graft-versus-Host Disease

Shiro Koh, Hideo Koh, Yasuhiro Nakashima, Takako Katayama, Manami Sakabe, Hiroshi Okamura, Takuro Yoshimura, Satoru Nanno, Mitsutaka Nishimoto, Yoshiki Hayashi, Takahiko Nakane, Hirohisa Nakamae, Masahiko Ohsawa, Masayuki Hino

Author information

Shiro Koh
Hematology, Graduate School of Medicine, Osaka City University, Japan
Hideo Koh
Hematology, Graduate School of Medicine, Osaka City University, Japan
Yasuhiro Nakashima
Hematology, Graduate School of Medicine, Osaka City University, Japan
Takako Katayama
Hematology, Graduate School of Medicine, Osaka City University, Japan
Manami Sakabe
Hematology, Graduate School of Medicine, Osaka City University, Japan
Hiroshi Okamura
Hematology, Graduate School of Medicine, Osaka City University, Japan
Takuro Yoshimura
Hematology, Graduate School of Medicine, Osaka City University, Japan
Satoru Nanno
Hematology, Graduate School of Medicine, Osaka City University, Japan
Mitsutaka Nishimoto
Hematology, Graduate School of Medicine, Osaka City University, Japan
Yoshiki Hayashi
Hematology, Graduate School of Medicine, Osaka City University, Japan
Takahiko Nakane
Hematology, Graduate School of Medicine, Osaka City University, Japan
Hirohisa Nakamae
Hematology, Graduate School of Medicine, Osaka City University, Japan
Masahiko Ohsawa
Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Japan
Masayuki Hino
Hematology, Graduate School of Medicine, Osaka City University, Japan

Keywords: chronic graft-versus-host disease, polymyositis, plasma cytokine, T-helper 1, T-helper 2, T-helper 17

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 16 Pages 2265-2270

DOI https://doi.org/10.2169/internalmedicine.55.6206

Details

Abstract

We herein describe a case of myelodysplastic syndrome with chronic graft-versus-host disease (cGVHD)-related polymyositis. On approximately day 1,570 post HLA-identical sibling bone marrow transplant, the patient presented with a fever, myalgia and liver dysfunction. A muscle biopsy revealed destruction of the muscle fibers and infiltration of CD20⁺ B cells and CD4⁺ and CD8⁺ T cells, and a liver biopsy confirmed the findings of cGVHD. An analysis of plasma cytokine profiles indicated elevation of not only T-helper (Th)1 and Th2, but also Th17 cytokines. Increases in these cytokines in addition to the invasion of inflammatory cells might be associated with the pathophysiology of cGVHD involving the muscle and liver.

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