Mansoura Veterinary Medical Journal

Sedative, analgesic and behavioral changes of caudal epidural injection of xylazine, magnesium sulphate in Egyptian water buffalo (Bubalus bubalis)

Ahmed Khalil, surgery, Anesthesiology &amp; Radiology, Faculty of Veterinary Medicine, Benha University, Benha, EgyptFollow
Atef Abd Al Galil, Department of Veterinary Surgery, Anesthesiology and Radiology, College of Veterinary Medicine, Monofia University, Shebin El-Kom, EgyptFollow
Mohamed Zeineldin, Department of Animal Medicine, College of Veterinary Medicine, Benha University, Benha, EgyptFollow
Seham Abo-Korae, Department of Pharmacology, College of Veterinary Medicine, Benha University, Benha, EgyptFollow
Ahmed sabek, Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.Follow

Corresponding Author

Khalil, Ahmed

Document Type

Original Article

Subject Areas

Surgery

Keywords

Buffalo, epidural, Locomotion, Magnesium sulphate, xylazine

Abstract

Objective: To assess and compare the effects of epidural xylazine (XY), magnesium sulphate (MG) and their combination (XY-MG) in buffalo. Design: Crossover study Animals: Seven healthy, non-pregnant buffalo Procedures: Buffaloes were allocated into one of three groups in a prospective randomized crossover design with two weeks washout period as the following: XY group, MG group and XY-MG group. The sedative, analgesic, and behavioral effects of XY, MG and their combination were evaluated prior to administration and at then after injection at 5, 10, 15, 30, 45, 60, 90 120, 150, 180, and 210 minutes. Results: Clinical and hematological variables were evaluated at baseline (0 minute) and then at 15, 30, 45, 60, 90, 120, 180, and 210-minutes post-administration. Buffaloes received XY-MG combination showed the fastest onset and resulted in the longer duration of epidural analgesia. The longest duration of complete sedation was recorded in group XY-MG. All treatment protocols caused mild ataxia and affected the heart rate, respiratory rate and rectal temperature of buffalo. There was a significant decrease in the blood glucose at 30 minutes after injection in all groups, returning to the baseline level by 180 minutes in XY-MG group and 210 minutes in XY and MG groups. Conclusion and clinical relevance: XY-MG combination may be used as epidural sedative and analgesic to control pain in buffalo.

How to Cite This Article

Khalil, Ahmed; Abd Al Galil, Atef; Zeineldin, Mohamed; Abo-Korae, Seham; and sabek, Ahmed (2022) "Sedative, analgesic and behavioral changes of caudal epidural injection of xylazine, magnesium sulphate in Egyptian water buffalo (Bubalus bubalis)," Mansoura Veterinary Medical Journal: Vol. 23: Iss. 1, Article 1.
DOI: https://doi.org/10.21608/mvmj.2021.102670.1090