Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives

Nassar, Ibrahim F.; Abdel Rahman, Adel A. H.; Adel Khalek, Heba A.; Sharaf, Afrah; El-Sayed, Wael A.

doi:10.21608/ejchem.2023.172380.7187

Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Specific Education, Ain Shams University, Abassia, Cairo, Egypt

² Chemistry Department, Faculty of Science, Menofia University, Shbien El-Kom, Egypt

³ Department of Chemistry, College of Science, Jazan University, Kingdom of Saudi Arabia

⁴ Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia

⁵ Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt

10.21608/ejchem.2023.172380.7187

Abstract

New substituted pyrimidine, pyrazole, pyridine and pyrrole derivatives were synthesized from an unsaturated arylacetylmine key derivative via cyclization reaction with the suitable corresponding reagent and their structures were characterized by elemental and spectral analyses. The anticancer, antimicrobial and anti-Hepatities B activity of the synthesized compounds were studied against a panel of cells and microbes. The results showed moderate to high activities for most of the tested compounds.

Keywords