Comparative study on the possible protective effect of boswellic acids and/or co-enzyme Q10 against stress-induced peptic ulcer in normally fed and protein malnourished rats

Document Type : Original research articles

Authors

1 Department of Pharmacology and Toxicology, International Medical Center (IMC), Cairo, Egypt

2 Department of Pharmacology and toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

Abstract

Peptic ulcer(PU) is one of the common diseases affecting mankind. 'It kills few but troubles many'. Available therapeutic drugs for peptic ulcers have failed to meet pharmacological expectations due to their drawbacks e.g. proton pump inhibitors. The current study was conducted to study the possible protective role of Boswellic acids and/or Co-enzyme Q10 against stress induced PU in the rats under the conditions of protein malnutrition(PM)& normally fed(NF), besides a possible involved mechanistic pathway. 2major groups were randomly divided; ("NF"&"PM" rats) each major group was classified into 5subgroups (6 rats each) using doses of 250 mg/kg for BA and 200 mg/kg for Co-Q10 orally 1 hr before stress as following:1unstressed(NF-control); 2unstressed(PM-control); 3(control ulcer-NF); 4(control ulcer-PM); 5(BA-NF); 6(BA-PM); 7(Co Q10-NF); 8(Co Q10-PM); 9combination of the BA and Co-Q10-NF); 10combination of BA and Co Q10-PM). After 21days from PM, rats were stressed (electric shock for 3hours at 30volts). parameters were; Ulcer and preventive index; Nonprotein sulfa hydrate(NPSH)compounds; Lipid peroxidase; Super oxide dismutase(SOD)activity; Glutathione S transferase(GST)activity; DT diaphorase activity[NAD(p)H oxidoreductase]; Serum albumin; Serum immunoglobulin(IgA); Autophagy factor; Beclin using Western Blot; Endoplasmic reticulum factor; Bax using PCR. Ulcer Index was an evidence of PU. PM as; Body weight loss and decreased Serum albumin. BA&Co-Q10 had Preventive Index and decreased inflammatory and stress biomarkers; (NPSH), Lipid peroxidase, (SOD), [NAD(p)H], (IgA). Pathway cascade products was through; Autophagy factor and Endoplasmic reticulum factor. BA and Co-Q10 can be introduced as protective agents against peptic ulcer due to its anti-inflammatory and antioxidant effects.

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Azhar International Journal of Pharmaceutical and Medical Sciences
Volume 1, Issue 3
The articles belongs to the special issue selected papers from Azhar 2nd International Conference of Pharmaceutical and Medical Sciences (2021)
November 2021
Pages 102-117

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