UTILITY OF THIOGLYCOLLIC ACID IN THE SYNTHESIS OF SOME NEWLY THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVA-TIVES AS ANTIMICROBIAL AGENTS

Authors

GAMEEL ELHAGALI, Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
HESSEN EL-TAMAMAY, Department of Chemistry, Faculty of Science, Sebha University, Sebha, Libya
MA-NSOUR EL-SENUSSI, Department of Chemistry, Faculty of Science, Sebha University, Sebha, Libya
ZAMZAM ELBASHER, Department of Chemistry, Faculty of Science, Sebha University, Sebha, Libya

Corresponding Author

ELHAGALI, GAMEEL

Document Type

Original Article

Subject Areas

Chemistry

Keywords

4-thiazolidinone; Thiazolo [3, 2-a] pyridines; antimicrobial activity

Abstract

A series of thiazolo[3,2-a] pyridine derivatives 3, 4a-d, 9a-e, 11a-e, and 13 were synthesized through the interaction of 4,5-dihydro-2-ethoxycarbonyl methyllidine-4-thiaz-olidinone 1 with the corresponding α,β-unsaturated nitrile compounds 2a-e, 6a-e, 10a-e,and 12, respectively.4-Thiazolidinone derivative 1 was reacted with 2 moles of p-chlorobenza-ldehyde to give 14 which was reacted with malononitrile to afford the corresponding thiazolo [3,2-a]pyridine derivative 15. Acetylation of compound 15 with acetic anhydride furnished N-acetyl amino derivative 16. The structures of these compounds were elucidated on the basis of their spectral data (IR, 1HNMR and MS).These compounds were also screened for their antimicrobial activity against pseudomonas aeruginosa, Bacillus subtilis, Penicillium italicum and Syncephalas trumracemosum by using paper disc diffusion method using Chloroamphenicoland Terbifinas standard drugs.

How to Cite This Article

ELHAGALI, GAMEEL; EL-TAMAMAY, HESSEN; EL-SENUSSI, MA-NSOUR; and ELBASHER, ZAMZAM (2010) "UTILITY OF THIOGLYCOLLIC ACID IN THE SYNTHESIS OF SOME NEWLY THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVA-TIVES AS ANTIMICROBIAL AGENTS," Al-Azhar Bulletin of Science: Vol. 21: Iss. 1, Article 16.
DOI: https://doi.org/10.21608/absb.2010.7332