A case of post-malaria neurological syndrome (PMNS) after treatment of falciparum malaria with artesunate and mefloquine

Takashi Odawara; Takeshi Matsumura; Takuya Maeda; Kazushige Washizaki; Aikichi Iwamoto; Takeshi Fujii

doi:10.2149/tmh.2009-09

Case report

A case of post-malaria neurological syndrome (PMNS) after treatment of falciparum malaria with artesunate and mefloquine

Takashi Odawara, Takeshi Matsumura, Takuya Maeda, Kazushige Washizaki, Aikichi Iwamoto, Takeshi Fujii

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JOURNAL FREE ACCESS

2009 Volume 37 Issue 3 Pages 125-128

DOI https://doi.org/10.2149/tmh.2009-09

View "Advance Publication" version (September 1, 2009).

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Abstract

Post-malaria neurological syndrome (PMNS) is a rare complication after the treatment of falciparum malaria. We describe a case of a 56-year-old man who developed ataxia, tremor, and confusion 16 days after a successful treatment of falciparum malaria with artesunate followed by mefloquine. Magnetic resonance imaging of the brain revealed no abnormality, and he recovered spontaneously without any specific treatment including corticosteroids. Inflammatory changes were found in the cerebrospinal fluid, suggesting a localized inflammatory reaction as the cause of the syndrome.

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