TUMORIGENICITY OF A RABBIT LYMPHOID CELL LINE TRANSFORMED BY HUMAN T-CELL LEUKEMIA VIRUS

Isao MIYOSHI; Ichiro KUBONISHI; Shizuo YOSHIMOTO; Yuji OHTSUKI; Tadaatsu AKAGI

doi:10.20772/cancersci1959.75.6_482

Isao MIYOSHI, Ichiro KUBONISHI, Shizuo YOSHIMOTO, Yuji OHTSUKI, Tadaatsu AKAGI

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Keywords: Rabbit lymphoid cell line, Human T-cell leukemia virus, Heterotransplantation, Hamsters

JOURNAL FREE ACCESS

1984 Volume 75 Issue 6 Pages 482-484

DOI https://doi.org/10.20772/cancersci1959.75.6_482

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Abstract

A rabbit lymphoid cell line transformed by human T-cell leukemia virus (HTLV) was inoculated into the peritoneal cavity of six newborn hamsters treated by antilymphocyte serum. All of them developed lethal tumors two weeks after implantation. The tumor cells were chromosomally of rabbit type, and harbored HTLV and HTLV antigens.

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