SEROEPIDEMIOLOGICAL STUDIES ON NASOPHARYNGEAL CARCINOMA BY FLUORESCENT ANTIBODY TECHNIQUES WITH CULTURED BURKITT LYMPHOMA CELL

Akiyoshi KAWAMURA Jr.; Mitsuru TAKADA; Atushi GOTOH; Kenji HAMAJIMA; Tsuneo SANPE; Michisato MURATA; Yohei ITO; Tadatoshi TAKAHASHI; Takato YOSHIDA; Takeshi HIRAYAMA; Shin-Mien TU; Chen-Hui LIU; Czau-Siung YANG; Chiu-Hwa WANG

doi:10.20772/cancersci1959.61.1_55

Akiyoshi KAWAMURA Jr., Mitsuru TAKADA, Atushi GOTOH, Kenji HAMAJIMA, Tsuneo SANPE, Michisato MURATA, Yohei ITO, Tadatoshi TAKAHASHI, Takato YOSHIDA, Takeshi HIRAYAMA, Shin-Mien TU, Chen-Hui LIU, Czau-Siung YANG, Chiu-Hwa WANG

Author information

Akiyoshi KAWAMURA Jr.
Department of Immunology, Institute of Medical Science, University of Tokyo
Mitsuru TAKADA
Department of Virology, Kitasato Institute
Atushi GOTOH
Department of Immunology, Institute of Medical Science, University of Tokyo
Kenji HAMAJIMA
Department of Immunology, Institute of Medical Science, University of Tokyo
Tsuneo SANPE
Department of Immunology, Institute of Medical Science, University of Tokyo
Michisato MURATA
Department of Immunology, Institute of Medical Science, University of Tokyo
Yohei ITO
Laboratory of Viral Oncology, Aichi Cancer Center Research Institute
Tadatoshi TAKAHASHI
Laboratory of Viral Oncology, Aichi Cancer Center Research Institute
Takato YOSHIDA
Laboratory of Viral Oncology, Aichi Cancer Center Research Institute
Takeshi HIRAYAMA
Epidemiology Division, National Cancer Center Research Institute
Shin-Mien TU
National Taiwan University, College of Medicine
Chen-Hui LIU
National Taiwan University, College of Medicine
Czau-Siung YANG
National Taiwan University, College of Medicine
Chiu-Hwa WANG
National Taiwan University, College of Medicine

JOURNAL FREE ACCESS

1970 Volume 61 Issue 1 Pages 55-71

DOI https://doi.org/10.20772/cancersci1959.61.1_55

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Abstract

Methods for detection of anti-EB virus antibody by fluorescent antibody techniques were standardized. The anti-EB virus antibody titers of normal subjects in Taiwan are significantly higher than that of the normal subjects in Japan. By ridit analysis, sera from infectious mononucleosis patients exhibit higher titer than those of leukemia, other cancers, and normal subjects. However, they were lower than those of the nasopharyngeal carcinoma and Burkitt lymphoma.
Anti-EB virus titer higher than 1:640 was found in the sera of 85.7% of Burkitt lymphoma patients (7 cases), 77.1% of Chinese nasopharyngeal carcinoma patients (48 cases) in Taiwan, and 63.6% of Japanese nasopharyngeal carcinoma patients (11 cases), as compared with around 15% in other malignancies and 5-15% in normal subjects.
This result indicates the presence of similar antibody, which possesses identical or at least similar reactivity against the EB-virus, in the sera of both nasopharyngeal carcinoma and Burkitt lymphoma patients.

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