Sonochemiluminescence (SCL) from aqueous solution of lucigenin (Luc²⁺) has been studied with using aliphatic amines, such as ethylamine, propylamine, dipropylamine, tripropylamine and trimethylamine (TEA) as coreactant. It is found that strong SCL was observed from oxygen saturated alkaline solution containing Luc²⁺ when small amount TEA was added into the solution. A possible pathway for Luc²⁺ SCL reaction is discussed. In the ultrasonic field, TEA can adsorb onto the cavitation bubble/solution interface where TEA is oxidized by OH• to form TEA•⁺ and subsequently produce a highly reducing TEA• from the deprotonation reaction of the TEA•⁺. TEA• is suggested to initiate the reduction reactions of Luc²⁺ and O₂ and lead to the generation of Luc•⁺ and O₂•^-, respectively. The radical-radical coupling reaction between Luc•⁺ and O₂•^- is expected to initiate the light emission.