Formulation and Optimization of Ketoprofen Loaded Solid Lipid Nanoparticles Using Central Composite Design

Abstract

Ketoprofen is belongs to Non-steroidal antiinflammatory drugs (NSAIDs) and characterized by low solubility and bioavailabilty. The present study was planned to explore potential of ketoprofen loaded solid lipid nanoparticles (SLN) as a drug carrier system. Ketoprofen SLN was prepared by solvent injection technique. The formulation was optimized by experimental design considering the concentrations of drug and lipid. The optimized formulation demonstrated reduce particle size, better entrapment efficiency and sustained drug release pattern. The optimized formulation showed sustained release of drug from coating capsules containing lyophilized SLNs with cellulose acetate phthalate in the simulated gastrointestinal fluid. It was concluded that the Ketoprofen loaded SLN based formulation incorporated in capsules was suitable for oral application and give better therapeutic effects compared to conventional dosage form.