Persistent Identifier
|
doi:10.18710/1IHNDD |
Publication Date
|
2023-12-14 |
Title
| Replication Data for: Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity |
Author
| Melum, Vebjørn (UiT The Arctic University of Norway)
Saenz de Miera, Cristina (University of Michigan)
Markussen, Fredrik (UiT The Arctic University of Norway)
Jaeger, Catherine (University of Strasbourg)
Cázarez-Márquez, Fernando (UiT The Arctic University of NorwayUiT The Arctic University of Norway) - ORCID: 0000-0002-7840-2048
Sandve, Simen (Norwegian University of Life Sciences) - ORCID: 0000-0003-4989-5311
Simonneaux, Valerie (University of Strasbourg)
Hazlerigg, David (UiT The Arctic University of Norway) - ORCID: 0000-0003-4884-8409
Wood, Shona (UiT The Arctic University of Norway) - ORCID: 0000-0002-8273-4045 |
Point of Contact
|
Use email button above to contact.
Wood, Shona (UiT The Arctic University of Norway) |
Description
| The following data is provided to support the publication: "Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity". The data provided are body and testis weight for phodopus sungorus raised on different photoperiods, the genome assembly statistics for Phodopus sungorus, a comparative analysis of genes present in tanycytes LASER captured from animals gestated and raised on different photoperiods with genes and clusters defined in a pseduotime analysis of tanycytes in mice. Finally we provide counts of JASPAR motifs occuring across the Phodopus sungorus genome. (2023-12-06)
Abstract from publication: In mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions. This phenomenon is driven by in utero effects of maternal melatonin on the production of thyrotropin (TSH) in the fetal pars tuberalis (PT) and consequent TSH receptor-mediated effects on tanycytes lining the 3rd ventricle of the mediobasal hypothalamus (MBH). Here we use LASER capture microdissection and transcriptomic profiling to show that TSH-dependent MPP controls the attributes of the ependymal region of the MBH in juvenile animals. In Siberian hamster pups gestated and raised on a long photoperiod (LP) and thereby committed to a fast trajectory for growth and reproductive maturation, the ependymal region is enriched for tanycytes bearing sensory cilia and receptors implicated in metabolic sensing. Contrastingly, in pups gestated and raised on short photoperiod (SP) and therefore following an overwintering developmental trajectory with delayed sexual maturation, the ependymal region has fewer sensory tanycytes. Post-weaning transfer of SP-gestated pups to an intermediate photoperiod (IP), which accelerates reproductive maturation, results in a pronounced shift towards a ciliated tanycytic profile and formation of tanycytic processes. We suggest that tanycytic plasticity constitutes a mechanism to tailor metabolic development for extended survival in variable overwintering environments. (2023-12-14) |
Subject
| Other |
Keyword
| Biology
Chronobiology
Tanycyte
Maternal programming |
Related Publication
| Vebjørn J. Melum, Cristina Sáenz de Miera, Fredrik A.F. Markussen, Fernando Cázarez-Márquez, Catherine Jaeger, Simen R. Sandve, Valérie Simonneaux, David G. Hazlerigg, Shona H. Wood, Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity, Current Biology, Volume 34, Issue 3, 2024, Pages 632-640.e6, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2023.12.042. doi: 10.1016/j.cub.2023.12.042. https://doi.org/10.1016/j.cub.2023.12.042. |
Language
| English |
Producer
| UiT The Arctic University of Norway (UiT) https://en.uit.no/ |
Contributor
| Data Manager : Grønvold, Lars
Data Manager : To, Thu-Hien
Hosting Institution : UiT The Arctic University of Norway |
Funding Information
| Tromsø Research Foundation: TFS2016SW
Tromsø Research Foundation: IS3_17_SW
The Research Council of Norway: Overseas research grant
Fonds Paul Mandel pour les recherches en neurosciences: epigenetic calendars
University of Strasbourg Institute 212 for Advanced Studies fellowship: epigenetic light
UiT The Arctic University of Norway: Arctic 213 seasonal timekeeping initiative (ASTI) |
Distributor
| UiT The Arctic University of Norway (UiT) https://dataverse.no/dataverse/uit |
Depositor
| Wood, Shona |
Deposit Date
| 2023-12-06 |
Date of Collection
| Start Date: 2020-01-01 ; End Date: 2023-03-20 |
Data Type
| Experimental data |
Software
| R, Version: V3.4 |