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Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease

Year 2021, Volume: 13 Issue: 1, 18 - 23, 11.03.2021
https://doi.org/10.18521/ktd.824963

Abstract

Objective: We aimed to investigate whether there is a predisposition to COVID-19 with ABO and Rh blood group systems.

Methods: The clinical data of 455 patients with COVID-19 seen between April 17, 2020, and June 30, 2020, at the Necip Fazıl City Hospital were retrospectively analyzed studied. The differences in the ABO blood group distribution between COVID-19 patients and the control group (7844 cases) were analyzed.

Results: The percentage of patients with type O blood in the COVID-19 group was significantly lower than that in the control group (29.7% vs. 35.6%, p = 0.009). The percentage of patients with type A and B blood in the COVID-19 set was higher than in the control group however, there were no significant differences, respectively (44.4% vs. 40.8%, 19.3% vs.16.6%, p = 0.134, p=0.123). Patients with blood group O had a lower risk of COVID-19 than A, B blood group patients (respectively; OR = 0.732, OR=0.594, p = 0.023, p=0.001). The risk of COVID-19 was higher for patients with blood groups A and B than with a blood group 0 (OR = 1.365, OR= 1.684, p = 0.023, p=0.001). The Rh blood group phenotype was not statistically significant in determining a patient’s vulnerability.


Conclusion: The results of the present study suggest that while the blood group 0 had a low risk and decreased risk for infection with SARS-CoV-2, whereas blood group A and B were associated related with an increased risk, indicating that certain specific ABO blood groups were connected correlated with SARS-CoV-2 susceptibility.

References

  • 1. Fehr AR, Perlman S. Coronaviruses: An overview of their replication and patho-genesis. Methods Mol Biol 2015; 1282: 1–23.
  • 2. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P et al. Coronavirus infections and immune responses. J Med Virol 2020; 92(4): 424– 32. 3. El Hassoun O, Valaskova Z, Polak S, Hulin I. Few Insights on the problem of COVID-19. Bratisl Med J 2020; 121 (7): 471-474.
  • 4. Cui J, Li F, Shi Z-L. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019; 17: 181-192.
  • 5. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol 2017; 39(5): 529-539.
  • 6. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5(4): 536-544.
  • 7. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed 2020; 91(1): 157-60.
  • 8. Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009; 25(2): 48-59.
  • 9. Reid ME, Mohandas N. Red blood cell blood group antigens: structure and function. Semin Hematol 2004; 41(2): 93-117.
  • 10. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinicalcharacteristics in patients with COVID-19. Clinica Chimica Acta 2020; 509: 220-223.
  • 11. Batool Z, Durrani SH, Tariq S. Association of ABO and Rh blood group types to hepatitis B, hepatitis C, HIV and syphilis infection, a five year’ experience in healthy blood donors in a tertiary care hospital. J Ayub Med Coll Abbottabad 2017;29(1): 90-92.
  • 12. Jing W, Zhao S, Liu J, Liu M. ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis. BMJ Open 2020; 10(1): e034114.
  • 13. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis 2002; 185(9):1335‐7.
  • 14. Branch DR. Blood groups and susceptibility to virus infection: new developments. Curr Opin Hematol. 2010; 17(6): 558‐564.
  • 15. Lebiush M, Rannon L, Kark JD. The relationship between epidemic influenza A (H1N1) and ABO blood group. J Hyg 1981; 87(1): 139‐46.
  • 16. Aho K, Pyhälä R, Visakorpi R. ABO associated genetic determinant in H1N1 influenza. Tissue Antigens 1980; 16(4): 310‐3.
  • 17. Naĭkhin AN, Katorgina LG, Tsaritsyna IM, Kım TN, Rezvik VN, Trusov NV et al. Indicators of collective immunity to influenza depending on the blood group and sex of the population. Vopr Virusol. 1989; 34(4): 419‐23.
  • 18. Guillon P, Clément M, Sébille V, Rivain JG, Chou CF, Ruvoën-Clouet N et al. Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 2008; 18(12): 1085–93.
  • 19. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395 (10223):507-13.
  • 20. Lindesmith L, Moe C, Marionneau S, Ruvoen N, Jiang X, Lindblad L et al. Human susceptibility and resistance to Norwalk virus infection. Nat Med 2003; 9: 548-553.
  • 21. Cheng Y, Cheng G, Chui CH, Lau FY, Chan PKS, Ng MHL et al. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA 2005; 293(12):1450-1.
  • 22. Pelzer U, Klein F, Bahra M, Sinn M, Dörken B, Neuhaus P et al. Blood group determinates incidence for pancreatic cancer in Germany. Front Physiol 2013; 4: 118.
  • 23. Abdollahi A, Mahmoudi-Aliabadi M, Mehrtash V, Jafarzadeh B, Salehi M. The Novel Coronavirus SARS-CoV-2 Vulnerability Association with ABO/Rh Blood Types. Iran J Pathol 2020; 15(3): 156-160.
  • 24. Alkouta TA, Alkoutb AM. ABO blood groups among Coronavirus disease 2019 patients. Iberoamerıcan Journal of Medıcıne 2020; 2(4): 268-274.
  • 25. Arac E, Solmaz I, Akkoc H, Dönmezdil S, Karahan Z, Kaya S et al. Association Between the Rh Blood Group and the Covid-19 Susceptibility. International Journal of Hematology and Oncology 2020; 30(2): 81-86.
  • 26. Dzik S, Eliason K, Morris EB, Kaufman RM, North CM. COVID‐19 and ABO blood groups. Transfusion. 2020; 60(8): 1883-4.
  • 27. Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X et al. Relationship between the ABO blood group and the COVID-19 susceptibility. medRxiv 2020. doi:10.1101/2020.03.11.20031096

ABO Kan Gruplarıyla SARS-COV-2 Enfeksiyonunun Neden Olduğu COVID-19 Hastalığı Arasındaki İlişki

Year 2021, Volume: 13 Issue: 1, 18 - 23, 11.03.2021
https://doi.org/10.18521/ktd.824963

Abstract

Amaç: Çalışmamızda ABO ve Rh kan grubu sistemleri ile COVİD-19’a yatkınlık olup olmadığı araştırılması hedeflenmiştir.


Gereç ve Yöntem: 17 Nisan – 30 Haziran 2020 arasında Necip Fazıl Şehir Hastanesine başvuran 455 COVID-19 hastası retrospektif olarak çalışılmıştır. COVID-19 hastaları ile 7844 kontrol grubu arasındaki kan grubunun dağılım farklıkları araştırılmıştır.

Bulgular: O kan grubu taşıyan COVİD 19 hastalarının oranı kontol grubu hastalarına göre anlamlı derecede düşük bulunmuştur (%29, %35, p = 0.009). A ve B kan grubu taşıyan Covid-19 hastalarının oranı kontrol grubuna göre daha yüksek bulunsa da istatistiksel olarak anlamlı bulunmadı (%44, %19.3, %16.6, p=0.123). COVİD 19 hastalarında O kan grubu taşıyan hastaların A kan grubu taşıyanlara göre daha düşük riskte bulundu (OR=0.732, OR=0.023, p=0.001). Covid -19 riski A ve B grubu taşıyan hastalarda O grubuna kıyasla daha fazla bulundu. (OR = 1.365, OR= 1.684, p = 0.023, p=0.001). Rh kan grup antigenleri hastalıkla istatistiksel olarak anlamlı bulunmadı.

Sonuç: Bu çalışmanın sonuçları; SARS-CoV 2 enfeksiyon riski O kan grubu taşıyan hastalarda daha düşük, A ve B kan grubu taşiyan hastalarda ise daha yüksek olup, ABO kan grubunun SARS-Cov-2 enfeksiyonu ile bağlantili olduğunu işaret etmektedir.

References

  • 1. Fehr AR, Perlman S. Coronaviruses: An overview of their replication and patho-genesis. Methods Mol Biol 2015; 1282: 1–23.
  • 2. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P et al. Coronavirus infections and immune responses. J Med Virol 2020; 92(4): 424– 32. 3. El Hassoun O, Valaskova Z, Polak S, Hulin I. Few Insights on the problem of COVID-19. Bratisl Med J 2020; 121 (7): 471-474.
  • 4. Cui J, Li F, Shi Z-L. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019; 17: 181-192.
  • 5. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol 2017; 39(5): 529-539.
  • 6. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5(4): 536-544.
  • 7. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed 2020; 91(1): 157-60.
  • 8. Storry JR, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology 2009; 25(2): 48-59.
  • 9. Reid ME, Mohandas N. Red blood cell blood group antigens: structure and function. Semin Hematol 2004; 41(2): 93-117.
  • 10. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinicalcharacteristics in patients with COVID-19. Clinica Chimica Acta 2020; 509: 220-223.
  • 11. Batool Z, Durrani SH, Tariq S. Association of ABO and Rh blood group types to hepatitis B, hepatitis C, HIV and syphilis infection, a five year’ experience in healthy blood donors in a tertiary care hospital. J Ayub Med Coll Abbottabad 2017;29(1): 90-92.
  • 12. Jing W, Zhao S, Liu J, Liu M. ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis. BMJ Open 2020; 10(1): e034114.
  • 13. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis 2002; 185(9):1335‐7.
  • 14. Branch DR. Blood groups and susceptibility to virus infection: new developments. Curr Opin Hematol. 2010; 17(6): 558‐564.
  • 15. Lebiush M, Rannon L, Kark JD. The relationship between epidemic influenza A (H1N1) and ABO blood group. J Hyg 1981; 87(1): 139‐46.
  • 16. Aho K, Pyhälä R, Visakorpi R. ABO associated genetic determinant in H1N1 influenza. Tissue Antigens 1980; 16(4): 310‐3.
  • 17. Naĭkhin AN, Katorgina LG, Tsaritsyna IM, Kım TN, Rezvik VN, Trusov NV et al. Indicators of collective immunity to influenza depending on the blood group and sex of the population. Vopr Virusol. 1989; 34(4): 419‐23.
  • 18. Guillon P, Clément M, Sébille V, Rivain JG, Chou CF, Ruvoën-Clouet N et al. Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 2008; 18(12): 1085–93.
  • 19. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395 (10223):507-13.
  • 20. Lindesmith L, Moe C, Marionneau S, Ruvoen N, Jiang X, Lindblad L et al. Human susceptibility and resistance to Norwalk virus infection. Nat Med 2003; 9: 548-553.
  • 21. Cheng Y, Cheng G, Chui CH, Lau FY, Chan PKS, Ng MHL et al. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA 2005; 293(12):1450-1.
  • 22. Pelzer U, Klein F, Bahra M, Sinn M, Dörken B, Neuhaus P et al. Blood group determinates incidence for pancreatic cancer in Germany. Front Physiol 2013; 4: 118.
  • 23. Abdollahi A, Mahmoudi-Aliabadi M, Mehrtash V, Jafarzadeh B, Salehi M. The Novel Coronavirus SARS-CoV-2 Vulnerability Association with ABO/Rh Blood Types. Iran J Pathol 2020; 15(3): 156-160.
  • 24. Alkouta TA, Alkoutb AM. ABO blood groups among Coronavirus disease 2019 patients. Iberoamerıcan Journal of Medıcıne 2020; 2(4): 268-274.
  • 25. Arac E, Solmaz I, Akkoc H, Dönmezdil S, Karahan Z, Kaya S et al. Association Between the Rh Blood Group and the Covid-19 Susceptibility. International Journal of Hematology and Oncology 2020; 30(2): 81-86.
  • 26. Dzik S, Eliason K, Morris EB, Kaufman RM, North CM. COVID‐19 and ABO blood groups. Transfusion. 2020; 60(8): 1883-4.
  • 27. Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X et al. Relationship between the ABO blood group and the COVID-19 susceptibility. medRxiv 2020. doi:10.1101/2020.03.11.20031096
There are 26 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Özlem Kirişci 0000-0003-4784-8183

Suat Özlük This is me 0000-0003-3918-3484

Ümmühan Su Topalca This is me 0000-0002-2299-3379

Nazik Doğramacı Köprülü This is me 0000-0001-8905-4109

Publication Date March 11, 2021
Acceptance Date January 10, 2021
Published in Issue Year 2021 Volume: 13 Issue: 1

Cite

APA Kirişci, Ö., Özlük, S., Topalca, Ü. S., Doğramacı Köprülü, N. (2021). Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease. Konuralp Medical Journal, 13(1), 18-23. https://doi.org/10.18521/ktd.824963
AMA Kirişci Ö, Özlük S, Topalca ÜS, Doğramacı Köprülü N. Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease. Konuralp Medical Journal. March 2021;13(1):18-23. doi:10.18521/ktd.824963
Chicago Kirişci, Özlem, Suat Özlük, Ümmühan Su Topalca, and Nazik Doğramacı Köprülü. “Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease”. Konuralp Medical Journal 13, no. 1 (March 2021): 18-23. https://doi.org/10.18521/ktd.824963.
EndNote Kirişci Ö, Özlük S, Topalca ÜS, Doğramacı Köprülü N (March 1, 2021) Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease. Konuralp Medical Journal 13 1 18–23.
IEEE Ö. Kirişci, S. Özlük, Ü. S. Topalca, and N. Doğramacı Köprülü, “Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease”, Konuralp Medical Journal, vol. 13, no. 1, pp. 18–23, 2021, doi: 10.18521/ktd.824963.
ISNAD Kirişci, Özlem et al. “Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease”. Konuralp Medical Journal 13/1 (March 2021), 18-23. https://doi.org/10.18521/ktd.824963.
JAMA Kirişci Ö, Özlük S, Topalca ÜS, Doğramacı Köprülü N. Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease. Konuralp Medical Journal. 2021;13:18–23.
MLA Kirişci, Özlem et al. “Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease”. Konuralp Medical Journal, vol. 13, no. 1, 2021, pp. 18-23, doi:10.18521/ktd.824963.
Vancouver Kirişci Ö, Özlük S, Topalca ÜS, Doğramacı Köprülü N. Relationship of ABO Blood Groups to SARS-COV-2 Infection Causing COVID-19 Disease. Konuralp Medical Journal. 2021;13(1):18-23.