Natural Remedies for Onychomycosis: A Review

Jump To References Section

Authors

  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,IN ORCID logo https://orcid.org/0009-0009-4274-0764
  • Faculty of Pharmacy, Vishwakarma University, Kondhwa Budruk - 411048, Pune, India ,IN
  • Faculty of Pharmacy, Vishwakarma University, Kondhwa Budruk - 411048, Pune, India ,IN
  • Faculty of Pharmacy, Vishwakarma University, Kondhwa Budruk - 411048, Pune, India ,IN
  • Faculty of Pharmacy, Vishwakarma University, Kondhwa Budruk - 411048, Pune, India ,IN
  • Faculty of Pharmacy, Vishwakarma University, Kondhwa Budruk - 411048, Pune, India ,IN

DOI:

https://doi.org/10.18311/jnr/2023/33695

Keywords:

Dermatophytes, Essential Oils, Fungus, Herbal, Nail, Plant-based Extract

Abstract

Onychomycosis, a fungus that causes nail colouring, nail separation, and nail plate growth, has infected the nail unit. There is a chance that the nail structure, nail bed, or nail layer could be infected. The term “onychomycosis” derives from the Greek words “onyx” (nail) and “mykes” (fungus). Around 50% of all consultations for nail diseases are for onychomycosis, the most common nail infection disorder. About 90% of toenail onychomycosis and 75% of fingernail onychomycosis are caused by dermophytes like Trichophyton rubrum and Trichophyton mentagrophytes. About 70% of yeast-borne onychomycosis cases are caused by Candida albicans. Epidemiological studies that have just been released estimate that onychomycosis affects every community worldwide at a rate of about 5.5 per cent. Onychomycosis is managed in different ways based on clinical categorization, the number of damaged nails, and the severity of the condition. The disadvantages of treatment are that oral therapies are frequently limited by drug interactions and probable hepatotoxicity, and topical antifungals have low efficacy if administered without nail plate biosurgery. The use of plants in medical treatments and herbal therapies is one of the less harmful, cheaper, and widely available alternatives to synthetic pharmaceuticals for treating fungal infections. Undoubtedly, dermatophytes can be inhibited by plant-based extracts as well as essential oils’ antifungal activities.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Published

2023-11-05

How to Cite

Talele, C. R., Talele, D. R., Barhate, G., Bendre, V., Marda, V., & Khandelwal, C. (2023). Natural Remedies for Onychomycosis: A Review. Journal of Natural Remedies, 23(4), 1347–1357. https://doi.org/10.18311/jnr/2023/33695

Issue

Section

Short Review
Received 2023-05-04
Accepted 2023-08-29
Published 2023-11-05

 

References

Scher RK, Daniel CR. Nails: diagnosis, therapy, surgery. Oxford, England: Elsevier, Saunders; 2005.

Sigurgeirsson B, Baran R. The prevalence of onychomycosis in the global population–a literature study. J Eur Acad Dermatol Venereol. 2014; 28(11):1480-91. https://doi.org/10.1111/jdv.12323 PMid:24283696 DOI: https://doi.org/10.1111/jdv.12323

Thomas J, Jacobson GA, Narkowicz CK, Peterson GM, Burnet H, Sharpe C. Toenail onychomycosis: an important global disease burden. J Clin Pharm Ther. 2010; 35(5):497-519. https://doi.org/10.1111/j.13652710.2009.01107.x PMid:20831675 DOI: https://doi.org/10.1111/j.1365-2710.2009.01107.x

Mayser P, Freund V, Budihardja D. Toenail onychomycosis in diabetic patients: issues and management. Am J Clin Dermatol. 2009; 10:211-20. https://doi.org/10.2165/00128071200910040-00001 PMid:19489654 DOI: https://doi.org/10.2165/00128071-200910040-00001

Ghannoum MA, Hajjeh RA, Scher R, Konnikov N, Gupta AK, Summerbell R, et al. A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns. J Am Acad Dermatol. 2000; 43(4):641-8. https://doi.org/10.1067/mjd.2000.107754 PMid:11004620 DOI: https://doi.org/10.1067/mjd.2000.107754

Hay RJ, Baran R. Onychomycosis: a proposed revision of the clinical classification. J Am Acad Dermatol. 2011; 65(6):1219-27. https://doi.org/10.1016/j.jaad.2010.09.730 PMid:21501889 DOI: https://doi.org/10.1016/j.jaad.2010.09.730

Elewski BE. Clinical pearl: proximal white subungual onychomycosis in AIDS. J Am Acad Dermatol. 1993; 29(4):631-2. https://doi.org/10.1016/S0190-9622(08)81867-1 PMid:8408798 DOI: https://doi.org/10.1016/S0190-9622(08)81867-1

Scher RK. Onychomycosis is more than a cosmetic problem. The British journal of dermatology. 1994; 130 (Suppl 43):15. https://doi.org/10.1111/j.1365-2133.1994.tb06087.x PMid:8186135 DOI: https://doi.org/10.1111/j.1365-2133.1994.tb06087.x

Boyko EJ, Ahroni JH, Cohen V, Nelson KM, Heagerty PJ. Prediction of diabetic foot ulcer occurrence using commonly available clinical information: the Seattle Diabetic Foot Study. Diabetes care. 2006; 29(6):1202-7. https://doi.org/10.2337/dc05-2031 PMid:16731996 DOI: https://doi.org/10.2337/dc05-2031

Szepietowski JC, Reich A, Pacan P, Garlowska E, Baran E. Evaluation of quality of life in patients with toenail onychomycosis by Polish version of an international onychomycosis-specific questionnaire. Journal of the European Academy of Dermatology and Venereology: JEADV. 2007; 21(4):491-6. DOI: https://doi.org/10.1111/j.1468-3083.2006.02004.x

https://doi.org/10.1111/j.14683083.2006.02004.x PMid:17373976

Scher RK, Baran R. Onychomycosis in clinical practice: factors contributing to recurrence. The British journal of dermatology. 2003; 149 (Suppl 65):5-9. https://doi.org/10.1046/j.1365-2133.149.s65.5.x PMid:14510969 DOI: https://doi.org/10.1046/j.1365-2133.149.s65.5.x

Biasi-Garbin RP, Demitto Fde O, Amaral RC, Ferreira MR, Soares LA, Svidzinski TI, et al. Antifungal potential of plant species from brazilian caatinga against dermatophytes. Revista do Instituto de Medicina Tropical de Sao Paulo. 2016; 58:18. https://doi.org/10.1590/S1678-9946201658018 PMid:27007561 PMCid:PMC4804555 DOI: https://doi.org/10.1590/S1678-9946201658018

Balakumar S, Rajan S, Thirunalasundari T, Jeeva S. Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi. Asian Pac J Trop Biomed. 2011; 4(8):654-7. https://doi.org/10.1016/S1995-7645(11)60166-1 PMid:21914546 DOI: https://doi.org/10.1016/S1995-7645(11)60166-1

Borgohain P, Saikia LR, Mahanta J. Herbal medicine as an alternative for the treatment of onychomycosis.

Runyoro DKB, Ngassapa OD, Nondo RSO, Melkiory P. Antifungal activity against onychomycosis causative fungi and brine shrimp lethality of a Tanzanian ornamental plant Euphorbia cotinifolia L. (Euphorbiaceae). J Pharm Sci. 2017; 9(1):63.

Morah FNI, Okoi WW. Euphorbia sanguinea stem sap as antifungal agent against Onychomycosis. Int J Adv Sci Res. 2016; 1:8-9.

Singh PS, Vidyasagar GM. Antifungal screening of 61 folkloric medicinal plant extracts against dermatophytic fungi Trichophyton rubrum. J Appl Pharm Sci. 2015; 5(5):38-40. https://doi.org/10.7324/JAPS.2015.50507 DOI: https://doi.org/10.7324/JAPS.2015.50507

Venugopal PV, Venugopal TV. Antidermatophytic activity of garlic (Allium sativum) in vitro. International journal of dermatology. 1995; 34(4):278-9. https://doi.org/10.1111/j.1365-4362.1995.tb01597.x PMid:7790146 DOI: https://doi.org/10.1111/j.1365-4362.1995.tb01597.x

Disegha GC, Akani NP. Antimycotic Effect of Allium sativum on Selected Fungi. Current Studies in Comparative Education, Science and Technology. 2015; 2(2):228-44.

Adam K, Sivropoulou A, Kokkini S, Lanaras T, Arsenakis M. Antifungal activities of Origanum vulgare subsp. hirtum, Mentha spicata, Lavandula angustifolia, and Salvia fruticosa essential oils against human pathogenic fungi. Journal of agricultural and food chemistry. 1998; 46(5):1739-45.

https://doi.org/10.1021/jf9708296 DOI: https://doi.org/10.1021/jf9708296

Ekwealor CC, Oyeka CA, Okoli I. Antifungal activities of some Nigerian medicinal plants against non-dermatophyte molds isolated from cases of onychomycosis among rice farmers in Anambra State, Nigeria. British Microbiology Research Journal. 2012; 2(2):62. https://doi.org/10.9734/BMRJ/2012/1248

Romero-Cerecero O, Román-Ramos R, Zamilpa A, JiménezFerrer JE, Rojas-Bribiesca G, Tortoriello J. Clinical trial to compare the effectiveness of two concentrations of the Ageratina pichinchensis extract in the topical treatment of onychomycosis. Journal of ethnopharmacology. 2009; 126(1):74-8. https://doi.org/10.1016/j.jep.2009.08.007 PMid:19683043 DOI: https://doi.org/10.1016/j.jep.2009.08.007

Runyoro DKB, Ngassapa OD, Nondo RSO, Melkiory P. Antifungal activity against onychomycosis causative fungi and brine shrimp lethality of a Tanzanian ornamental plant Euphorbia cotinifolia L. (Euphorbiaceae). Journal of Pharmaceutical Sciences and Research. 2017; 9(1):63.

Sreelatha GL, Babu UV, Sharath Kumar LM, Soumya K, Sharmila T. Investigation on biochemical characterisation and in vitro antifungal efficacy of plant extracts on Malassezia furfur. Int J Pharma Bio Sci. 2015; 6:B1027-B41.

Chhillar AK. Identification and toxicological studies of antifungal molecule from natural sources. 2013 [Available from: http://hdl.handle.net/10603/9807

Ekwealor CC, Oyeka CA, Okoli I. Antifungal activities of some nigerian medicinal plants against non-dermatophyte molds isolated from cases of onychomycosis among rice farmers in Anambra State, Nigeria. Microbiol Res J Int. 2012; 2(2):62-70. https://doi.org/10.9734/BMRJ/2012/1248 DOI: https://doi.org/10.9734/BMRJ/2012/1248

Babu P, Subhasree R. Antimicrobial activities of Lawsonia inermis - A review. Acad J Plant Sci. 2009; 2.

Sharma A, Sharma K. Assay of antifungal activity of Lawsonia inermis Linn and Eucalyptus citriodora Hook. J Pharm Res. 2011; 4(5):1313-4.

Giwanon R, Soradech S, Limsiriwong P, Ruengsri S, Peungsumrong S, Panapong K, et al. Preliminary antionychomycosis efficacy study of cream from selected medicinal plant. Thai J Pharm Sci. 2016; 40:73-5.

Lin HC, Kuo Y-L, Lee W-J, Yap H-Y, Wang S-H. Antidermatophytic activity of ethanolic extract from Croton tiglium. Biomed Res Int. 2016; 2016:3237586. https:// doi.org/10.1155/2016/3237586 PMid:27446946 PMCid: PMC4947497 DOI: https://doi.org/10.1155/2016/3237586

Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA. Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts. Plants (Basel, Switzerland). 2017; 6(4). https://doi.org/10.3390/plants6040042 PMid:28937585 PMCid: PMC5750618 DOI: https://doi.org/10.3390/plants6040042

Lopes G, Pinto E, Salgueiro L. Natural products: an alternative to conventional therapy for dermatophytosis? Mycopathologia. 2017; 182:143-67. https://doi.org/10.1007/s11046-016-0081-9 PMid:27771883 DOI: https://doi.org/10.1007/s11046-016-0081-9

Seleem D, Pardi V, Murata RM. Review of flavonoids: A diverse group of natural compounds with anti-Candida albicans activity in vitro. Archives of oral biology. 2017; 76:76-83. https://doi.org/10.1016/j.archoralbio.2016.08.030 PMid:27659902 DOI: https://doi.org/10.1016/j.archoralbio.2016.08.030

Herrera CL, Alvear M, Barrientos L, Montenegro G, Salazar LA. The antifungal effect of six commercial extracts of Chilean propolis on Candida spp. Ciencia e investigación agraria. 2010; 37(1):75-84. https://doi.org/10.4067/S071816202010000100007 DOI: https://doi.org/10.4067/S0718-16202010000100007

Mulaudzi RB, Ndhlala AR, Kulkarni MG, Van Staden J. Pharmacological properties and protein binding capacity of phenolic extracts of some Venda medicinal plants used against cough and fever. Journal of Ethnopharmacology. 2012; 143(1):185-93. https://doi.org/10.1016/j.jep.2012.06.022 PMid:22732728 DOI: https://doi.org/10.1016/j.jep.2012.06.022

Serpa R, França EJG, Furlaneto-Maia L, Andrade CGTJ, Diniz A, Furlaneto MC. In vitro antifungal activity of the flavonoid baicalein against Candida species. Journal of medical microbiology. 2012; 61(12):1704-8. https://doi.org/10.1099/jmm.0.047852-0 PMid:22918868 DOI: https://doi.org/10.1099/jmm.0.047852-0

Duval A, Averous L. Characterization and physicochemical properties of condensed tannins from Acacia catechu. Journal of agricultural and food chemistry. 2016; 64(8):1751-60. https://doi.org/10.1021/acs.jafc.5b05671PMid:26853705 DOI: https://doi.org/10.1021/acs.jafc.5b05671

Dos Santos C, Vargas Á, Fronza N, Dos Santos JHZ. Structural, textural and morphological characteristics of tannins from Acacia mearnsii encapsulated using sol-gel methods: Applications as antimicrobial agents. Colloids and Surfaces B: Biointerfaces. 2017; 151:26-33. https://doi.org/10.1016/j.colsurfb.2016.11.041 PMid:27940166 DOI: https://doi.org/10.1016/j.colsurfb.2016.11.041

Yoshida T, Amakura Y, Yoshimura M. Structural features and biological properties of ellagitannins in some plant families of the order Myrtales. International journal of molecular sciences. 2010; 11(1):79-106. https://doi.org/10.3390/ ijms11010079 PMid:20162003 PMCid:PMC2820991 DOI: https://doi.org/10.3390/ijms11010079

Reddy MK, Gupta SK, Jacob MR, Khan SI, Ferreira D. Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L. Planta medica. 2007; 53(05):461-7. https://doi.org/10.1055/s-2007-967167 PMid:17566148 DOI: https://doi.org/10.1055/s-2007-967167

Yamaguchi MU, Garcia FP, Cortez DAG, Ueda-Nakamura T, Filho BPD, Nakamura CV. Antifungal effects of ellagitannin isolated from leaves of Ocotea odorifera (Lauraceae). Antonie Van Leeuwenhoek. 2011; 99:507-14. https://doi.org/10.1007/s10482-010-9516-3 PMid:20922478 DOI: https://doi.org/10.1007/s10482-010-9516-3

Klewicka E, Sójka M, Klewicki R, Kołodziejczyk K, Lipińska L, Nowak A. Ellagitannins from raspberry (Rubus idaeus L.) fruit as natural inhibitors of Geotrichum candidum. Molecules. 2016; 21(7):908. https://doi.org/10.3390/molecules21070908 PMid:27420041 PMCid:PMC6273995 DOI: https://doi.org/10.3390/molecules21070908

Navarro‐García VM, Rojas G, Avilés M, Fuentes M, Zepeda G. In vitro antifungal activity of coumarin extracted from Loeselia mexicana Brand. Mycoses. 2011; 54(5):e569-e71. https://doi.org/10.1111/j.14390507.2010.01993.x PMid:21605187 DOI: https://doi.org/10.1111/j.1439-0507.2010.01993.x

Raut JS, Shinde RB, Chauhan NM, Karuppayil SM. Phenylpropanoids of plant origin as inhibitors of biofilm formation by Candida albicans. Journal of Microbiology and Biotechnology. 2014; 24(9):1216-25. https://doi.org/10.4014/jmb.1402.02056 PMid:24851813 DOI: https://doi.org/10.4014/jmb.1402.02056

Shahzad M, Sherry L, Rajendran R, Edwards CA, Combet E, Ramage G. Utilising polyphenols for the clinical management of Candida albicans biofilms. International journal of antimicrobial agents. 2014; 44(3):269-73. https://doi.org/10.1016/j.ijantimicag.2014.05.017 PMid:25104135 DOI: https://doi.org/10.1016/j.ijantimicag.2014.05.017

Da Silva DL, Magalhães TFF, Dos Santos JRA, De Paula TP, Modolo LV, De Fatima A, et al. Curcumin enhances the activity of fluconazole against Cryptococcus gattii‐induced cryptococcosis infection in mice. Journal of applied microbiology. 2016; 120(1):41-8. https://doi.org/10.1111/jam.12966 PMid:26442997 DOI: https://doi.org/10.1111/jam.12966

Kumar Pandey V, Shams R, Singh R, Dar AH, Pandiselvam R, Rusu AV, et al. A comprehensive review on clove (Caryophyllus aromaticus L.) essential oil and its significance in the formulation of edible coatings for potential food applications. Frontiers in nutrition. 2022; 9:987674. https://doi.org/10.3389/fnut.2022.987674 PMid:36185660 PMCid:PMC9521177 DOI: https://doi.org/10.3389/fnut.2022.987674

Shan B, Cai YZ, Sun M, Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. Journal of agricultural and food chemistry. 2005; 53(20):7749-59. https://doi.org/10.1021/jf051513y PMid:16190627 DOI: https://doi.org/10.1021/jf051513y

Batiha GE, Alkazmi LM, Wasef LG, Beshbishy AM, Nadwa EH, Rashwan EK. Syzygium aromaticum L. (Myrtaceae): Traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules. 2020; 10(2). https://doi.org/10.31032/IJBPAS/2021/10.2.5350 DOI: https://doi.org/10.31032/IJBPAS/2021/10.2.5350

Pinto E, Vale-Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and Dermatophyte species. Journal of medical microbiology. 2009; 58(Pt 11):1454-62. https://doi.org/10.1099/jmm.0.010538-0 PMid:19589904 DOI: https://doi.org/10.1099/jmm.0.010538-0

de Groot AC, Schmidt E. Tea tree oil: contact allergy and chemical composition. Contact Derm. 2016; 75(3):129-43. https://doi.org/10.1111/cod.12591 PMid:27173437 DOI: https://doi.org/10.1111/cod.12591

Yadav E, Kumar S, Mahant S, Khatkar S, Rao R. Tea tree oil: a promising essential oil. J Essent Oil Res. 2017; 29(3):20113. https://doi.org/10.1080/10412905.2016.1232665 DOI: https://doi.org/10.1080/10412905.2016.1232665

Hammer KA, Carson CF, Riley TV. Melaleuca alternifolia (tea tree) oil inhibits germ tube formation by Candida albicans. Med Mycol J. 2000; 38(5):354-62. https://doi.org/10.1080/mmy.38.5.354.361 DOI: https://doi.org/10.1080/mmy.38.5.354.361

Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, et al. Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. BMC Complementary and Alternative Medicine. 2009; 9(1):111. https://doi.org/10.1186/1472-6882-9-6 PMid:19296830 PMCid:PMC2664784 DOI: https://doi.org/10.1186/1472-6882-9-6

Ojha PK, Poudel DK, Rokaya A, Satyal R, Setzer WN, Satyal P. Comparison of volatile constituents present in commercial and lab-distilled frankincense (Boswellia carteri) essential oils for authentication. Plants. 2022; 11(16):2134. https://doi.org/10.3390/plants11162134 PMid:36015437 PMCid:PMC9415502 DOI: https://doi.org/10.3390/plants11162134

Park M-J, Gwak K-S, Yang I, Choi W-S, Jo H-J, Chang J-W, et al. Antifungal activities of the essential oils in Syzygium aromaticum (L.) Merr. Et Perry and Leptospermum petersonii Bailey and their constituents against various dermatophytes. J Microbiol. 2007; 45(5):460-5.

Borotová P, Čmiková N, Galovičová L, Vukovic NL, Vukic MD, Tvrdá E, et al. Antioxidant, antimicrobial, and antiinsect properties of Boswellia carterii essential oil for food preservation improvement. Sci Hortic [Internet]. 2023; 9(3). https://doi.org/10.3390/horticulturae9030333 DOI: https://doi.org/10.3390/horticulturae9030333

Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils–a review. Food Chem Toxicol. 2008; 46(2):446-75. https://doi.org/10.1016/j.fct.2007.09.106 PMid:17996351 DOI: https://doi.org/10.1016/j.fct.2007.09.106

Hartati R, Insanu M, Mudrika SN, Fidrianny I. Phytochemical compounds and pharmacological activities of lemon (Citrus limon L.) – Update Review. Int J Pharm Sci. 2021; 12(2):1496-505. https://doi.org/10.26452/ijrps.v12i2.4727 DOI: https://doi.org/10.26452/ijrps.v12i2.4727

Kim KN, Ko YJ, Yang HM, Ham YM, Roh SW, Jeon YJ, et al. Anti-inflammatory effect of essential oil and its constituents from fingered citron (Citrus medica L. var. sarcodactylis) through blocking JNK, ERK and NF-κB signaling pathways in LPS-activated RAW 264.7 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013; 57:126-31.

https://doi.org/10.1016/j.fct.2013.03.017 PMid:23541436 DOI: https://doi.org/10.1016/j.fct.2013.03.017

Oussalah M. Inhibitory effects of selected plant essential oils on the growth of four pathogenic bacteria: E. coli O157:H7, Salmonella typhimurium, Staphylococcus aureus and Listeria monocytogenes. Food control. 2007; 18(5):414-20. https://doi.org/10.1016/j.foodcont.2005.11.009 DOI: https://doi.org/10.1016/j.foodcont.2005.11.009

Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Pérez-Álvarez J. Antifungal activity of lemon (Citrus lemon L.), mandarin (Citrus reticulata L.), grapefruit (Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils. Food Control. 2008; 19:1130-8. https://doi.org/10.1016/j.foodcont.2007.12.003 DOI: https://doi.org/10.1016/j.foodcont.2007.12.003

De Sousa DP, Hocayen PD, Andrade LN, Andreatini R. A systematic review of the anxiolytic-like effects of essential oils in animal models. Molecules [Internet]. 2015; 20(10):18620-60. https://doi.org/10.3390/molecules201018620 PMid:26473822 PMCid:PMC6332383 DOI: https://doi.org/10.3390/molecules201018620

Burt S. Essential oils: their antibacterial properties and potential applications in foods--A review. International journal of food microbiology. 2004; 94(3):223-53. https://doi.org/10.1016/j.ijfoodmicro.2004.03.022 PMid:15246235 DOI: https://doi.org/10.1016/j.ijfoodmicro.2004.03.022

Vakili-Ghartavol M, Arouiee H, Golmohammadzadeh S, Naseri M. Antifungal activity of Mentha Piperita L. essential oil. Acta Sci Pol Hortorum Cultus. 2022; 21(1):143-52. https://doi.org/10.24326/asphc.2022.1.12 DOI: https://doi.org/10.24326/asphc.2022.1.12

Ali B, Al-Wabel NA, Shams S, Ahamad A, Khan SA, Anwar F. Essential oils used in aromatherapy: A systemic review. Asian Pac J Trop Biomed. 2015; 5(8):601-11. https://doi.org/10.1016/j.apjtb.2015.05.007 DOI: https://doi.org/10.1016/j.apjtb.2015.05.007