Efficacy of Analgesic Therapy after Hip and Knee Arthroplasty



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Abstract

Efficacy of pain syndrome drug therapy using aceclofenac in combination with tolperisone after total knee and hip arthroplasty was studied. Study included 100 patients. Patients from group 1 ( n =30) received ketorolac, from group 2 (n=35) - aceclofenac, from group 3 (n=35) - aceclofenac in combination with tolperisone, for 3 postoperative days in recommended doses. Severity of pain syndrome by VAS, range of motion, and dynamics of soft tissue edema was assessed. It was shown that combined therapy with aceclofenac and tolperisone was more effective in pain syndrome reduction, contributed to more marked regress of soft tissue edema and more complete restoration of movements as compared to monotherapy with nonsteroid anti- inflammatory drugs.

About the authors

P. V Markov

Republican hospital № 2 - Center for emergency care, Yakutsk, RF

G. A Pal’shin

Medical Institute «North-Eastern Federal University named after M.K. Amosov», Yakutsk, RF

A. N Komissarov

Republican hospital № 2 - Center for emergency care, Yakutsk, RF

References

  1. Богомолов А.Н., Канус И.И. Анестезиологическое обеспечение и послеоперационное обезболивание при тотальном эндопротезировании коленного сустава. Новости хирургии. 2012; 20 (6): 102-10.
  2. Лебедева Р.Н., Никода В.В. Фармакотерапия острой боли. М.: Аир-Арт; 1998.
  3. Мукуца И.Г., Царенко С.В., Лядов К.В., Конева Е.С., Волошин А.Г. Мультимодальное обезболивание после тотального эндопротезирования тазобедренного сустава. Травматология и ортопедия России. 2012; 4 (66): 72-5.
  4. Насонова В.А. Ацеклофенак - безопасность и эффективность. Русский медицинский журнал. 2003; 11 (5): 3-6.
  5. Hаskinsson E.C., Irani M., Murray F. A large prospective open-label, multi-centre SAMM study, comparing the safety of aceclofenac with diclofenac in patients with rheumatic disease. Eur. J. Rheumatol. Inflam. 2000; 17: 1-7.
  6. Henrotin Y., de Leval X., Mathy-Hartet M., Mouithys- Mickalad A., Deby-Dupont G., Dogne J.M. et al. In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators. Inflamm. Res. 2001; 50 (8): 391-9.
  7. Lidburg P.S., Vojnovic J., Warner T.D. «COX2/COX1 selectivity of aceclofenac in comparison with celecoxib and rofecoxob in the human whole blood assay. Proc. Fith world Congress of the OARS, Barselona, 2000; Suppl B: Th053.
  8. Корсакова Ю.Л. Применение ацеклофенака (аэртала) при боли в спине. Современная ревматология. 2011; 2: 55-61.
  9. Martín-Mola E., Gijуn-Baсos J., Ansoleaga J.J. Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis. Rheumatol. Int. 1995; 15 (3): 111-6.
  10. Pasero G., Marcolongo R., Serni U., Parnham M.J., Ferrer F. A multi-centre, double-blind comparative study of the efficacy and safety of aceclofenac and diclofenac in the treatment of rheumatoid arthritis. Curr. Med. Res. Opin.1995; 13 (6): 305-15.
  11. Ward D.E., Veys E.M., Bowdker J.M., Roma J. Comparison of aceclofenac with diclofenac in the treatment of osteoarthrosis. Clin. Rheumatol. 1995; 14: 656-62.
  12. Pareek A., Chandurkar N. Comparison of gastrointesti- nal safety and tolerability of aceclofenac with diclofenac: a multicenter, randomized, double-blind study in patients with knee osteoarthritis. Curr. Med. Res. Opin. 2013; 29 (7): 849-59.
  13. Yanagawa A., Endo T., Kusakari K., Kudo T., Shimada J., Misushima Y. Endoscopic evaluation of aceclofenac- induced gastroduodenal mucosal damage: a double- blind comparison with sodium diclofenac and placebo. Jpn J. Rheumacol. 1998; 18: 249-59.
  14. Раскина Т.А. Ацеклофенак: терапевтическая эффективность при остеоартрозе. Современная ревматология. 2010; 4: 51-3.
  15. Парфенов В.А. Мидокалм в лечении болезненного мышечного спазма при болях в спине. Неврологический журнал. 2004; 6: 39-42.
  16. Dulin J., Kovacs L., Ramm S. et al. Evaluation of seda- tive effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride. Results of a prospective, randomized, double blind, placebocontrolled trial. Pharmacopsychiat. 1998; 31: 137-42.
  17. Солчани Я., Фаркаш Ш. Аналгетическая активность мидокалма дополняет воздействие на мышечный спазм. Качественная клиническая практика. 2003; 1: 83-8.
  18. Авакян Г.Н., Чуканова Е.И., Никонов А.А. Применение мидокалма при купировании вертеброгенных болевых синдромов. Журнал неврологии и психиатрии им. С.С. Корсакова. 2000; 5: 26-31.

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