Characterization of Hydration Behaviour and Modeling of Film Formulation

Abstract

Hydration behavior of hydrogel-based polymeric film possesses great importance in mucosal drug delivery. Modified Lag phase sigmoid model was used for the investigation of hydration of the film. Kaolin incorporated HPMC K100LVCR (H_L) and K100M (H_H) films containing dexamethasone as a model drug have been prepared for studying swelling kinetics. Swelling of H_L and H_H films was decreased with the gradual increase of kaolin content and H_H of higher viscosity has shown higher value than H_L matrix. Kaolin also inhibited the film erosion process. Mathematically modified lag phase sigmoid model demonstrated similarity of the predicted swelling content with the observed value. High R² and small RMSE value confirmed the successful fitting of the modified lag phase sigmoid model to the experimental data of swelling content. τ value similar to the observed one was obtained. This modified model could be reliable enough for estimating hydration process in food grains, food packaging films etc.