Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) trial data

Burke, R. 2024. Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) trial data. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00003552.

Burke, R. Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) trial data [Internet]. London School of Hygiene & Tropical Medicine; 2024. Available from: https://doi.org/10.17037/DATA.00003552.

Burke, R (2024). Computer Aided Screening for Tuberculosis in Low Resource Environments (CASTLE) trial data. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00003552.

Description

CASTLE is a cluster randomised trial comparing enhanced TB diagnostics (urine SILVAMP-LAM plus urine LF-LAM plus digital chest Xray with computer aided diagnosis plus usual care) to usual care alone, among adults living with HIV admitted to hospital. Clusters are day of admission to hospital. Primary outcome is TB treatment started prior to hospital discharge. Secondary outcomes are all-cause mortality at 56 days from enrolment, undiagnosed TB at time of discharge from hospital, and TB treatment initiation within 24 hours of enrolment. Data was collected using a combination of face-to-face questionnaire, laboratory test results, and information gathered from written medical records by trained research assistants.

Methods

Description of data capture

Data collected using a combination of face-to-face questionnaire, laboratory test results, and information gathered from written medical records by trained research assistants.

Data capture method

Questionnaire, Aggregation, Physical measurements and tests

Data Collection Period

From	To
5 September 2020	31 March 2022

Date (Date submitted to LSHTM repository)

8 March 2024

Language(s) of written materials

English

People & Groups

Data Creators	Burke, R
Associated roles	MacPherson, P (Co-Investigator) and Corbett, EL (Co-Investigator)
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre	TB Centre
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom, Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi