Kirkegaard, Maja; Sonne, Christian; Dietz, Rune; Letcher, Robert J; Jensen, Asger L; Hansen, Signe Stige; Jenssen, Bjørn Munro; Grandjean, Philippe (2011): Thyroid hormone and gland status of Greenland sledge dogs (Canis lupus familiaris) exposed to contaminated blubber [dataset publication series]. PANGAEA, https://doi.org/10.1594/PANGAEA.812009, Supplement to: Kirkegaard, M et al. (2011): Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds. Ecotoxicology and Environmental Safety, 74(1), 157-163, https://doi.org/10.1016/j.ecoenv.2010.08.040
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Abstract:
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128 µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SumDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics.
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Latitude: 68.719000 * Longitude: -52.793000
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Comment:
Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150
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Creative Commons Attribution 3.0 Unported (CC-BY-3.0)
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Datasets listed in this publication series
- Kirkegaard, M; Sonne, C; Dietz, R et al. (2011): (Table 1) Concentrations of free and total thyroid hormones in adult sledge dogs (C. lupus familiaris) exposed to contaminated blubber. https://doi.org/10.1594/PANGAEA.812006
- Kirkegaard, M; Sonne, C; Dietz, R et al. (2011): (Table 2) Concentrations of free and total thyroid hormones in sledge dog offspring (C. lupus familiaris) exposed to contaminated blubber. https://doi.org/10.1594/PANGAEA.812007
- Kirkegaard, M; Sonne, C; Dietz, R et al. (2011): (Table 3) Thyroid hormone gland weight and canine TSH in sledge dogs (C. lupus familiaris) exposed to contaminated blubber. https://doi.org/10.1594/PANGAEA.812008