Informative value of the clinical parameters of metabolic syndrome at primary acute ischemic stroke
DOI:
https://doi.org/10.15587/2313-8416.2016.61223Keywords:
cerebral stroke, metabolic syndrome, clinical components of metabolic syndromeAbstract
The aim of research is determination of connection between the ischemic insult and the number of components of metabolic syndrome (MS).
Methods. The research included 160 patients with initial acute ischemic stroke: 103 patients with MS diagnosis and 58 without MS. All patients were equal by age and sex.
All patients underwent clinic-neurological, laboratory and instrumental examinations.
The subtype of stroke was detected according to TOAST classification. At statistic processing there were used xi-square and Mann-Whitney test.
Results. At detection of MS it was revealed: with 3 components – in 31,4% of patients, with 4ones – in 40,2% of patients, with 5 ones - in 28,4% of patients. Among the atherothrombotic subtype prevailed patients with 4 components of MS, among cardioembolic one – with 3, with lacunar one there were not revealed any changes.
The indices of high arterial pressure and of hyperthiglyceridemia of the heavy degree prevailed in patients with 4 and 5 MS components. The increase of MS components number caused the more intensive hyperglycemia in patients. According to indices of glycosylated hemoglobin there was established that the prevalence of chronic disorder of carbohydrate metabolism was detected only at lacunar subtype of stroke and only in patients with 5 MS components.
Conclusions. There was established that the increase of MS components number worsens the hemodynamic indices, deepens atherothrombotic potential that correlates with data of the blood lipid spectrum and the degree of heaviness of carbohydrate-metabolic changes
References
Faralli, A., Bigoni, M., Mauro, A., Rossi, F., Carulli, D. (2013). Noninvasive Strategies to Promote Functional Recovery after Stroke. Neural Plasticity, 2013, 1–16. doi: 10.1155/2013/854597
Grimaud, O., Bejot, Y., Heritage, Z., Vallee, J., Durier, J., Cadot, E. et. al (2011). Incidence of Stroke and Socioeconomic Neighborhood Characteristics: An Ecological Analysis of Dijon Stroke Registry. Stroke, 42 (5), 1201–1206. doi: 10.1161/strokeaha.110.596429
Hobzej, M. K., Zinchenko, O. M., Golubchykov, M. V. et. al (2013). Stan nevrologichnoi' sluzhby v Ukrai'ni u 2012 roci. Kharkiv, 29.
Mishhenko, T. S. (2014). Bor'ba s insul'tom: sostojanie medicinskoj pomoshhi v Ukraine i v mire. Mezhdunarodnyj nevrologicheskij zhurnal, 7 (69), 2–7.
Zozulja, I. S., Zozulja, A. I. (2015). Likuvannja hvoryh na mozkovyj insul't. Ukr. med. Chasopys, 1 (105), 36–39.
Soler, E. P., Ruiz, V. C. (2010). Epidemiology and Risk Factors of Cerebral Ischemia and Ischemic Heart Diseases: Similarities and Differences. Current Cardiology Reviews, 6 (3), 138–149. doi: 10.2174/157340310791658785
Cortez-Dias, N., Martins, S., Belo, A. et. al (2011). Comparison of definitions of metabolic syndrome in relation to risk for coronary artery disease and stroke. Rev. Port. Cardiol., 30 (2), 139–169.
Air, E. L., Kissela, B. M. (2007). Diabetes, the Metabolic Syndrome, and Ischemic Stroke: Epidemiology and possible mechanisms. Diabetes Care, 30 (12), 3131–3140. doi: 10.2337/dc06-1537
Konradi, A. O., Rotar, O. P., Korostovtseva, L. S., Ivanenko, V. V., Solntcev, V. N., Anokhin, S. B. et. al (2011). Prevalence of Metabolic Syndrome Components in a Population of Bank Employees from St. Petersburg, Russia. Metabolic Syndrome and Related Disorders, 9 (5), 337–343. doi: 10.1089/met.2011.0028
Khang, Y.-H., Cho, S.-I., Kim, H.-R. (2010). Risks for cardiovascular disease, stroke, ischaemic heart disease, and diabetes mellitus associated with the metabolic syndrome using the new harmonised definition: Findings from nationally representative longitudinal data from an Asian population. Atherosclerosis, 213( 2), 579–585. doi: 10.1016/j.atherosclerosis.2010.09.009
Hwang, I.-C., Kim, K.-K., Jee, S.-H., Kang, H.-C. (2011). Comparison of Predictability of Cardiovascular Events between Each Metabolic Component in Patients with Metabolic Syndrome Based on the Revised National Cholesterol Education Program Criteria. Yonsei Medical Journal, 52 (2), 220. doi: 10.3349/ymj.2011.52.2.220
Liu, C., Feng, M., Fang, X. H. et al. (2011). Metabolic syndrome is an independent risk factor for cardiovascular disease events in patients with ischemic stroke. Zhonghua Xin Xue Guan Bing Za Zhi, 39 (4), 358–362. doi: 10.3760/cma.j.issn.0253-3758.2011.04.016
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A. et. al (2009). Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation, 120 (16), 1640–1645. doi: 10.1161/circulationaha.109.192644
Zhang, W.-W., Liu, C.-Y., Wang, Y.-J., Xu, Z.-Q., Chen, Y., Zhou, H.-D. (2009). Metabolic syndrome increases the risk of stroke: a 5-year follow-up study in a Chinese population. Journal of Neurology, 256 (9), 1493–1499. doi: 10.1007/s00415-009-5150-2
Wang, J., Ruotsalainen, S., Moilanen, L., Lepisto, P., Laakso, M., Kuusisto, J. (2008). The Metabolic Syndrome Predicts Incident Stroke: A 14-Year Follow-Up Study in Elderly People in Finland. Stroke, 39 (4), 1078–1083. doi: 10.1161/strokeaha.107.499830
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