FOUNDER OF RESEARCH IN CHEMISTRY OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS IN DNIPROVSK UNIVERSITY (to the 100th anniversary of the birth of Рrof. Z. F. SOLOMKO)
DOI:
https://doi.org/10.15421/jchemtech.v29i3.240427Keywords:
Z. F. Solomko, heterocyclic compounds, 1,5-benzodiazepines, biological activityAbstract
The article is dedicated to the 100th birth anniversary of a famous organic chemist, a specialist in the study of heterocyclic compounds, in particular, 1,5-benzodiazepines, Doctor of Chemical Sciences, Honored Professor of Dnieper University Zinaida F. Solomko (1921-2001).
The main milestones of the scientist's life path are considered. She was born on September 20, 1921 in Uspenivka village of Sinelnikovsky district of Ekaterinoslav province. As a third-year student of Faculty of Chemistry of Dnipropetrovsk University, she volunteered for the front, where she was a nurse at a sorting evacuation hospital until the end of the war. In 1947 she graduated from the university, and two years later she entered the graduate school in the Department of Organic Chemistry of Dnepropetrovsk State University (DSU), where she was working on her dissertation under the guidance of prof. F. I. Berezovskaya. In 1952 she defended her dissertation «Methods for separate determination of thiophene and carbon disulfide in commercial benzene», and in 1973 - her doctoral dissertation - «Heterocyclization of N-aryl-b-aminoacids». Later, until the end of her life, she worked as an associate professor and then a professor in the Department of Organic Chemistry in DSU.
The main directions of scientific researches of Z. F. Solomko are analyzed. In the early 70's of the last century, she began to study chemical properties and methods of synthesis of 1,5-benzodiazepines and their derivatives, establishing her own scientific school in this area. Many of the substances she synthesized have shown biological activity and can be used in medical practice as tranquilizers, diuretics, sulfamides. She also studied chemistry of phosphorus and organosulfur compounds, the properties of aminoacids, sulfonanilides, and so on. She is an author of more than 250 scientific publications, 38 certificates of inventions, a textbook for high school «Organic Chemistry and Fundamentals of Static Biochemistry».
The article also reveals some personality traits of Z. F. Solomko, as well as gives memories of her colleagues and students about her, and tells about her approaches to execution of experimental research, style of leadership of graduate students, pedagogical and social activities.
While writing of the article, materials from the archives of Oles Honchar Dnipro National University (DNU), Archive-museum of Faculty of Chemistry, scientific publications of Z. F. Solomko and her students were used.
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