T. G. Gutor¹, N. F. Timchenko¹*, O. I. Matsyura²

¹Department of Social Medicine, Economics and Organization of Health Care,
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;
²Department of Pediatrics №2, Danylo Halytsky Lviv National
Medical University, Lviv, Ukraine;
*e-mail: timchenkonataliaf@ukr.net

Received: 08 May 2023; Revised: 05 June 2023;
Accepted: 11 June 2023; Available on-line: 11 July 2023

Adverse reproductive outcome before term is a polyetiological pathology associated with demographic crisis. Some adverse outcomes include perinatal and neonatal infant mortality, major morbidity and mortality of children under two years, violation of psychomotor and physical development, cognitive disturbances and disability of children under age five. Finding ways to solve these issues remain a priority. The research involved two female groups. The experimental group included 403 women after the involuntary termination of pregnancy, premature birth or in case of threat of miscarriage; the control group included 402 women with physiological course of pregnancy and parturient with full-term pregnancy. The study required the application of systemic approaches and methods including structural, logical, medical and statistical analyses. The survey revealed more than 20 infectious risk factors and more than 70 factors of extragenital origin. The most significant infectious pathologies included COVID-19 (36.23 ± 2.29% and 14.93 ± 1.78%), herpes type 1 (5.96 ± 1.18% and 1.0 ± 0.50%), toxoplasmosis (4.22 ± 1.0% and 1.0 ± 0.50%) and chlamydial infection (4.22 ± 1.0% 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). The most significant extragenital pathologies involved autoimmune thyroiditis (8.68 ± 1.40% and 0.75 ± 0.43%), type 1 diabetes mellitus (2.23 ± 0.74% and 0%) and allergic rhinitis/sinusitis (3.97 ± 0.97% and 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). Obtained results will be used in the development of a personified risk-oriented model for the prevention of preterm pregnancy loss.

Keywords: adverse reproductive outcomes before term, extragenital pathology, infectious pathology, risk factors, risk-oriented model