The influence of adaptive hormones (insulin, adrenaline and prednisolone) on the pancreatic islets functional state was studied in experiments on rats with alloxan-induced diabetes. It was estimated by the concentration of glucose in the blood, insulin and zinc in B-cells. The presence of cytochemically determined zinc in the hippocampus neurons, pinealocytes and thymic epithelial cells (TEC) has allowed a comparative research of changes of this metal content in the hippocampus, pineal, thymus and pancreas glands. For determination of zinc content in the cells, a highly selective cytochemical reaction of 8-(p-toluenesulfonylamino)-quinoline was used. It has been found that alloxan not only caused the increase of glycemia, insulin deficiency in the pancreatic B cells (87%) but also a development the zinc deficit (48-59% ) in hippocampus, epiphysis, thymus and pancreatic islets. The opposite changes in blood and cells were observed after insulin injection. It can be explained by inhibition of secretory processes. Adrenaline and prednisolone introduction also induced an increase in zinc content in pancreatic islets, hippocampus (27-32%), epiphysis (27-35%), thymus (25-33%), accompanied by a doubled glucose concentration in blood. The insulin deficit in B-cell (56-81%) as well as a zinc deficit in the hippocampal neurons (5-25%), pinealocytes (19-38%), TEC (32-42%) and B-insulocytes (24-41%) were less marked in case of the adaptive hormones prescription to the animals with diabetes. The correlation analysis of changes in zinc content showed a link between the hippocampus neurons, the cells of pineal and the thymus glands, B-insulocytes, suggesting the existence of hippocampal-epiphyseal-thymic system of regulation of insular apparatus function.