To evaluate the effects of cisapride on gastric emptying, gastric emptying was measured in sixhealthy volunteers using radioisotopic techniques which were establised three areas of interest, i.e. the whole stomach, the proximal stomach and the antrum. Following results were obtained.
1. At the half emptying times, cisapride induced a more rapid gastric emptying than did placebo in 5 of 6 volunteers.
2. By analyzing gastric emptying curves obtained from three areas of interst, it was suggested that cisapride enhanced the transfer of gastric contents from the proximal stomach to the antrum together with the antral emptying, so that gastric emptying was accelerated.