Relationships between Heart Weight, DNA Content, Cell Count and Thickness of Muscle Fibers in Human Heart Muscle

Toshiaki MORISHITA; Rikuro SASAKI; Shizuka ICHIKAWA; Hirotsugu YAMAGIWA; Shoichi YAMAGATA

doi:10.1536/ihj.12.325

Toshiaki MORISHITA, Rikuro SASAKI, Shizuka ICHIKAWA, Hirotsugu YAMAGIWA, Shoichi YAMAGATA

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Keywords: Autopsy, Hypertrophy, Cell division, Hyperplasia, Chemical determination, Histometric estimation, Cardiovascular and renal disease, Malignant tumor

JOURNAL FREE ACCESS

1971 Volume 12 Issue 4 Pages 325-334

DOI https://doi.org/10.1536/ihj.12.325

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Abstract

Chemical determination of DNA content and histometric estimation of the cell count and the thickness of muscle fibers in the human left ventricle were performed on 24 autopsy cases, in order to know relationships between heart weight, DNA content, cell count and thickness of muscle fibers with increasing heart weight. The following conclusions were obtained.
It is considered that DNA synthesis and the increase in cell count are attributable for the increase in heart weight. The mean thickness of muscle fibers in cardiovascular and renal disease group was bigger than that in malignant tumor and miscellaneous disease group. Then it is concluded that not only hypertrophy of muscle fibers but hyperplasia of heart muscle cells occur in cardiac hypertrophy.

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