Endocrine Abstracts

Introduction: Hypothyroidism - is a clinical syndrome, which occurs owing to the constant insufficiency of thyroid gland hormones in organisms for a long period of time or as a result of reducing their biological effect as a tissue. Now, hypothyroidism occurs in 7-10 % of females and 2-3 % of men. Subclinical hypothyroidism – is characterized by a gradual aggravating chronic condition of the thyroid gland of immune pathologic character, normal level (T4) of free thyroxin, and a large amount of thyroid-stimulating hormone (TSH). It is in the leading place among all pathologies of the thyroid gland according to the prevalence in the population.

Purpose: At present, the mentioned pathology is considered to be the most important. But, nevertheless, its diagnostics and study of concomitant diseases still cause some problems. If not revealed in proper time latent hypothyroidism may produce a number of grave conditions. Our aim is concentrated on estimating the lipid and hormonal profile of women ill with latent hypothyroidism, preventing its transition to manifested hypothyroidism, and stopping the development of various diseases.

Material and methods: We divided according to the degree of the thyroid-stimulating hormone of examined women. In our examination, 100 women took part from 17 years to 66 years. We divided all patients 3 groups according to the amount of thyroid-stimulating hormone:

Result: According to our investigations, the lipid profile of patients ill with subclinical hypothyroidism have been examined. The studies showed that general cholesterol, lipoproteins with low density, triglycerides have been considerably increased in the first and second groups. It consists of 32 patients.

Conclusion: In patients with an amount of TG of more than 4 mU/l the level of general cholesterol, triglycerides, lipoproteins with low density (LLD) have been found in quantities, whereas the level of lipoproteins with high density (LHD) was considerably lower. It has been determined that in patients who haven’t reached the age of 66 the risk of acquiring ischemic heart disease is high as a result of subclinical hypothyroidism.