Enzyme Inhibition Studies on N-Substituted Sulfonamides Derived from m-phenetidine

Organic synthesis of various compounds followed by biological activities is the going on methodology in the world for pharmacological evaluation. The undertaken research is the synthesis of N-(3-ethoxyphenyl)-4-methylbenzenesulfonamide (3) through condensation reaction of m-phenetidine (1) and 4-methylbenzenesulfonyl chloride (2) using basic aqueous media of sodium carbonate. Further, the synthesized compound 3 was reacted with different alkyl/aralkyl halides (4a-j) using DMF as aprotic polar solvent and NaH as a base to yield 5a-j compounds. The synthesized molecules were characterized from their spectral data. The synthesized compounds were evaluated against cholinesterase (AChE and BChE), lipoxygenase (LOX), urease, chymotrypsin and tyrosinase enzymes; and found to be the moderate inhibitor against tyrosinase enzyme.