Deferoxamine (DFA, N′-[5-(acetyl-hydroxy-amino)- pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino] pentyl]-N-hydroxy-butane diamide) is a chelating agent used to remove excess iron from the body and to reduce organ and tissue damage. DFA enhances both iron regulatory protein 1 (IRP1) expression and its endoplasmic reticulum (ER) membrane-binding activity, as occurs in hypoxia, an ER stress, in cultured cells. Here, we show that DFA promotes ER stress via an ER signal pathway
Received: 2007-12-28
Published Online: 2014-6-2
Published in Print: 2008-4-1
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