Abstract
Azadirachtin A in ppm quantity inhibits proliferation and monolayer formation of Spodoptera frugiperda (Sf 9) insect cells in monolayer culture. The incubated cells demonstrate reduced rates of protein synthesis which finally leads to cell death. This growth inhibiting activity is compared with other botanicals such as ohchinin, salannin and volkensin. The high and specific activity of azadirachtin A on insect cells is discussed in comparison with its effect on a mammalian cell line, based on 2D PAGE analysis of the total protein contents.
Received: 1992-11-26
Published Online: 2014-6-2
Published in Print: 1993-6-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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