The fungal metabolite mevinolin, known to be a potent hypocholesterolemic agent, excerts in vitro a strong inhibitory effect on microsomal HMG-CoA reductase from etiolated radish seedlings at a concentration of about three magnitudes lower than the Km towards the natural substrate (S)-HMG-CoA (I50 = 2.5 × 10-9 ᴍ). Beside this, mevinolin significantly inhibits the root elongation of radish as well as of wheat seedlings already at low concentrations of 10 to 100 ppb (= 2.5 × 10-8 to 2.5 × 10-7 ᴍ).
: 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase; Mevalonate Formation; Mevinolin (monacolin K); Enzyme Inhibition; Biocide
Received: 1981-11-2
Published Online: 2014-6-2
Published in Print: 1982-2-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
