Change language
English Deutsch
Change currency
€ EUR £ GBP $ USD
BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Aktivierung von Steroidsystemen zu alkylierenden Agenzien / Activation of Steroid Systems to Alkylating Agents

  • Manfred Wilk and Karlheinz Schmitt
From the journal Zeitschrift für Naturforschung B
https://doi.org/10.1515/znb-1981-0222
Download article (PDF)

Abstract

7-Dehydrocholesterol and ergosterol are oxidised by iodine and FeCl3 under "physiologically similar" conditions to highly reactive alkylating species. These can be trapped by nucleophiles, such as 1-methylimidazole.

The oxidation of the sterols to those alkylating species is discussed as a model-reaction for the first step in chemical carcinogenesis by endogene substrates.

Keywords: Oxidation; 7-Dehydrocholesterol; Endogene Carcinogenesis
Received: 1980-3-26
Revised: 1980-8-18
Published Online: 2014-6-2
Published in Print: 1981-2-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Download article (PDF)
From the journal
Zeitschrift für Naturforschung B
Zeitschrift für Naturforschung B
Volume 36 Issue 2

Journal and Issue

Articles in the same Issue

Darstellung von Natrium-Chelaten des Methylen-bis[iminodiphenylphosphorans] [1] / Synthesis of Sodium-Chelates of Methylen-bis[iminodiphenylphosphorane] [1]
Darstellung symmetrisch bisaminierter Carbodiphosphorane R2NPh2P=C=PPh2NR2 [1] / Synthesis of Symmetrical Diaminocarbodiphosphoranes R2NPh2P=C=PPh2NR2 [1]
Die Kristallstruktur von Methyltriphenylphosphoniumhexachlorotitanat [MePh3P]2TiCl6 / The Crystal Structure of Methyltriphenylphosphonium Hexachlorotitanate
Darstellung und Charakterisierung von Tetrabutylammonium-Tetraiodooxotechnetat(V), (TBA) [TcOI4] / Preparation and Characterization of Tetrabutylammonium Tetraiodooxotechnetate(V), (TBA)[TcOI4]
Reaktion von Hiallium(III)-carboxylaten mit Ketonen / Reactions of Thallium(III) Carboxylates with Ketones
Cyclische Diazastannylene, X [1] Die Kristall-und Molekülstruktur eines Moleküls mit verzerrt-würfelförmigem Sn4N3O-Käfig / Cyclic Diazastannylenes, X [1] The Crystal and Molecular Structure of a Molecule with a Distorted Cube-Shaped Sn4N3O-Cage
Zur Reaktion aromatischer Phosphanderivate mit Elektronen, I. / On the Reaction of Aromatic Phosphane Derivatives with Electrons, I.
Diazaborolidyl - ein stabiler Substituent an Schwefel-Stickstoff-Verbindungen / Diazaborolidyl - a Stable Substituent at Sulfur Nitrogen Compounds
Strukturen und Schwingungsspektren des Tetramethylammonium -a -dodekawolframatosilikats und des Tetrabutylammonium-β-dodekawolframatosilikats / Structures and Vibrational Spectra of Tetramethylammonium a-Dodecatungstosilicate and Tetrabutylammonium β-Dodecatungstosilicate
Synthese und Struktur von 1.2.3-Thiadiazol- und 1.2.3-Selenadiazol-Pentaearbonyl-Komplexen der Elemente Chrom und Wolfram / Synthesis and Structure of 1,2,3-Thiadiazol- and 1,2,3-Selenadiazol-Pentacarbonyl-Complexes of the Elements Chromium and Tungsten
Über Cyanohalogenomercurate der Alkalimetalle / On Cyanohalogenomercurates of Alkali Metals
Metallomethane, IV [1] Molekül-und Kristallstruktur von Bis(chloroquecksilber)metlian CH2(HgCl)2 / Metallomethanes, IV [1] Molecular and Crystal Structure of Bis(chloromercuri)methane CH2(HgCl)2
Pt(II)-, Pd(II)-und Cu(II)-Komplexe mit dem 4.4.5.5-Tetramethylimidazolin-1-oxyl-2-m-pyridyl-3-oxid-Liganden / Pt(II), Pd(II) and Cu(II) Complexes with the Ligand 4,4,5,5-Tetramethylimidazohne-1-oxyl-2-m-pyridyl-3-oxide
ÜbergangsmetaU-Schwefelylid-Komplexe, XI [1] Struktur und Reaktivität von n5 -Thiacyclohexadienyl-1-oxid-chrom-KompIexeii / Transition Metal Sulfur Ylide Complexes, XI [1] Structure and Reactivity of n5-Thiacyclohexadienyl-1-oxide Complexes of Chromium
Übergangsmetallkomplexe von Diazenen, XVI [1] Struktur und Mößbauerdaten von (2.3-Diazanorbornen)Fe3(CO)9 / Transition Metal Complexes of Diazenes, XVI [1] Structure and Mössbauer Data of (2,3-Diazanorbornene)Fe3(CO)9
Electret Model for the Collective Behaviour of Biological Systems
The Metal Complexes of Heterocyclic β-Diketones and their Derivatives, Part VIII Synthesis, Structure, Proton NMR and Infrared Spectral Studies of the Complexes of Al(III), Fe(III), Co(III), Rh(III), In(III), and Zr(IV) with l-Phenyl-3-methyl-4-trifluoroacetyl-pyrazolone-5 (HPMTFP)
(Aminoethinyl)metallierimgen, IX [1] Umsetzungen von Inaminen mit Cyanketenen / (Aminoethynyl)metallations, IX [1] Reactions of Ynamines with Cyanoketenes
Die Darstellung von 1.3-Dunethyl-6-hydroxy-dihychothymin durch photochemische Wasser-Addition an 1.3-Dimethyl-thymin+ / Preparation of 1,3-Dimethyl-6-hydroxy-dihydrothymine by Photochemical Addition of Water to 1,3-Dimethyl-thymine+
Kinetische Untersuchung der Methanolyse von chlormethylierten Phenolen / Kinetic Studies of the Methanolysis Reaction of Chloromethylated Phenols
Stabilization of a Host-Guest Type Complex by Bifurcated Hydrogen Bonds : 18-crown-6 · (2,4-Dinitrophenylhydrazine)2a
Aktivierung von Steroidsystemen zu alkylierenden Agenzien / Activation of Steroid Systems to Alkylating Agents
A New Route to 1H-Pyrido[l,2-a]quinazolines
Synthesis of Kaempferol-3-0-(3″,4″ -di-O-a-L-rhamnopyranosy)-β-D-galactopyranoside and its Comparison with the Natural Ascaside Isolated from Astragalus caucasicus
Isosilychristin, ein neues Flayonolignan aus Silybum marianum L. Gaertn. / Isosilychristin, a New Flavonolignan from Silybum marianum L.Gaertn.
Beiträge zur Chemie des Phosphors, 89 [1] Cyclisierung eines 1.3-DihaIogen-1.2.3- triorganyltriphosphans zum entsprechenden Triorganyl-cyclotriphosphan / Contributions to the Chemistry of Phosphorus, 89 [1] Cyclization of a 1,3-Dihalogen-1,2,3- triorganyltriphosphane to the Corresponding Triorganyl-cyclotriphosphane
Darstellung von Antimon(V)tetrafluoridpentafluorotellurat(VI), SbF4OTeF5 und Antimon(V)trifluorid-bis[pentafluorotellurat(VI)], SbF3(OTeF5)2 / Preparation of Antimony(V)tetrafluoridepentafluorotellurate( VI), SbF4OTeF5 and Antimony(V)trifluoride-bis[pentafluorotellurate( VI)], SbF3(OTeF5)2
Eine neue Darstellungsmethode für Caesiumhydroxid / A New Preparative Method for Cesiumhydroxide
Redox Properties of Platinum Uracil "Blues": A New Type of Paramagnetic Species
Hochdruckreaktionen, XIII [1] Synthese von(—)Cannabidiol unter hohen Drucken / High Pressure Reactions, XIII [1] Synthesis of (—) Cannabidiol at High Pressure
Isolation of a New Natural Quinone, 2-Hydroxy-6-methoxy-3,5-dimethyl-1,4-benzoquinone, from the Potato Culture Solation of Phoma wasabiae Yokogi
Sulfonamidyls, 4. Ab Initio MO Calculations on Sulfonyl and Carbonyl Substituted Aminyl Radicals
Downloaded on 9.6.2024 from https://www.degruyter.com/document/doi/10.1515/znb-1981-0222/html
Scroll to top button