Abstract
In recent years, the role of mitochondrial dynamics in neurodegenerative diseases has becoming increasingly important. More and more evidences have shown that in pathological conditions, abnormal mitochondrial divisions, especially Drp1-Fis1-mediated divisions, play an important role in the occurrence and development of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, glaucoma, and other neurodegenerative diseases. This review highlights several new mechanisms of physiological fission of mitochondria and the difference/connection of physiological/pathological mitochondrial fission. In addition, we described the relationship between abnormal mitochondrial dynamics and neurodegenerative diseases in detail and emphatically summarized its detection indicators in basic experiments, trying to provide references for further mechanism exploration and therapeutic targets.
Funding source: the Science and Technology Department of Hunan Province, China
Award Identifier / Grant number: 2021JJ30891
Funding source: the Project of Graduate Independent Exploration and Innovation Plan of Central South University of China
Award Identifier / Grant number: 1053320210359
Acknowledgments
This work was supported by the Project of Graduate Independent Exploration and In-novation Plan of Central South University of China [grant number 1053320210359]; the Science and Technology Department of Hunan Province, China [grant number 2021JJ30891].
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This work was funded by the Science and Technology Department of Hunan Province, China (No. 2021JJ30891) and the Project of Graduate Independent Exploration and Innovation Plan of Central South University of China (No. 1053320210359).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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