Abstract
Scientists are searching for reactive oxygen species, which have been associated with various health issues like heart problems, neurological disorders, inflammation, and aging. Salen complexes have proven to be effective in multiple oxidative stress situations and have been used as catalase and superoxide mimetics. To explore this further, three mixed complexes were synthesized using a Schiff base (salen) and a sugar (d-glucose) with Co(II), Ni(II), and Cu(II) ions. These complexes were then diagnosed by different analytical and spectral techniques. Stoichiometry, stereochemistry, some physical properties, and the method of bonding complexes were measured. Comparisons of the IR and 1HNMR spectra of the ligands with the complexes demonstrated the involvement of the azomethine group of the ligand in the chelation process. The mass spectra and TGA agree with the proposed formula of the complexes, and the conductivity and UV–Vis data supported the octahedral geometry of the complexes, and information was obtained from partial parameter calculations by molecular modeling. The metal complexes exhibited strong antimicrobial and antioxidant properties when compared to standard drugs. The like-superoxide and catalyst mimetic complexes were screened using DPPH ABTS, revealing their effectiveness.
Acknowledgments
Mr. Saleh Bufarwa expresses his gratitude to Mr. Omran Muftah, Faculty of Pharmacy at Omar Al-Mukhtar University, for his assistance in conducting some analyses. The author also extend their sincere thanks to Mr. Abdul-Jalil Hamad for providing some of the requirements for this research., as well as the Department of Chemistry, Omar Al-Mukhtar University, for providing research facilities.
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Research ethics: Not applicable.
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Author contributions: H.B. and S.B—Conceptualization, Validation, Writing an original draft, Investigation, Methodology, Data curation. R.E. and R.H—Data curation, Supervision, Writing—review and editing, Validation. R.E.—Sofware, Visualization, Writing—original draft, Methodology, and Validation. S.B—Sofware, Visualization, Writing—original draft, Validation. H.B.—Writing-review and editing, Validation “The authors have accepted responsibility for the entire content of this manuscript and approved its submission.”
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Competing interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The raw data can be obtained on request from the corresponding author.
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