Development of ruthenium-based complexes as anticancer agents: toward a rational design of alternative receptor targets

References

Adams, J. R.; Bennett, M. A. Transition metal complexes of tethered arenes. Adv. Organomet. Chem. 2006, 54, 293–331.10.1016/S0065-3055(05)54007-3Search in Google Scholar

Adeniyi, A. A.; Ajibade, P. A. Inhibitory activities and possible anticancer targets of Ru(II)-based complexes using computational docking method. J. Mol. Graphics Model2012, 38, 60–69.10.1016/j.jmgm.2012.08.004Search in Google Scholar PubMed

Adeniyi, A. A.; Ajibade, P. A. Comparing the suitability of autodock, gold and glide for the docking and predicting the possible targets of Ru(II)-based complexes as anticancer agents. Molecules2013a, 18, 1–20.10.3390/molecules18043760Search in Google Scholar PubMed PubMed Central

Adeniyi, A. A.; Ajibade, P. A. Computational studies of the electronic, conductivities, and spectroscopic properties of hydrolysed Ru(II) anticancer complexes. Spectr. Acta Pt. A2013b, 115, 426–436.10.1016/j.saa.2013.06.057Search in Google Scholar PubMed

Adeniyi, A. A.; Ajibade, P. A. Effects of bidentate coordination on the molecular properties of RAPTA-C based complexes using theoretical approach. J. Mol. Model2013c, 19, 1325–1338.10.1007/s00894-012-1683-xSearch in Google Scholar PubMed

Adeniyi, A. A.; Ajibade, P. A. Insights into the intramolecular properties of η⁶-arene-Ru-based anticancer complexes using quantum calculations. J. Chem. 2013d, 892052, 1–14.Search in Google Scholar

Adeniyi, A. A.; Ajibade, P. A. Theoretical study of the electronic and spectroscopic properties of some Ru(II) anticancer complexes. Spectr. Acta Pt. A2013e, 105, 456–465.10.1016/j.saa.2012.12.016Search in Google Scholar PubMed

Adeniyi, A. A.; Ajibade, P. A. An insight into the anticancer activities of Ru(II) based metallocompounds using docking methods. Molecules2014a, 18, 10829–10856.10.3390/molecules180910829Search in Google Scholar PubMed PubMed Central

Adeniyi, A. A.; Ajibade, P. A. Computational properties of hydrated and unhydrated: η⁶-toluene and η⁶-triflorotoluene half-sandwich Ru(II) anticancer complexes. J. Biomol. Struct. Dyn. 2014b, 32, 1351–1365.10.1080/07391102.2013.819299Search in Google Scholar PubMed

Adeniyi, A. A.; Ajibade, P. A. Theoretical study of the interatomic properties of ruthenium half sandwich anticancer compounds containing Ru-N bonds. Asian J. Chem. 2015, 27, 907–918.10.14233/ajchem.2015.17412Search in Google Scholar

Akbayeva, D. N.; Gonsalvi, L.; Oberhauser, W.; Peruzzini, M.; Vizza, F.; Brüggeller, P.; Romerosa, A.; Sava, G.; Bergamo, A. Synthesis, catalytic properties and biological activity of new water soluble ruthenium cyclopentadienyl PTA complexes [(C₅R₅)RuCl(PTA)₂] (R=H, Me; PTA=1,3,5-triaza-7-phosphaadamantane). Chem. Commun. (Camb.)2003, 264–265.10.1039/b210102eSearch in Google Scholar PubMed

Al-Lawati, H. A. J.; Suliman, F. E. O.; Al Kindy, S. M. Z.; Al-Lawati, A. M.; Varma, G. B.; Nour, I. E. M. Enhancement of on chip chemiluminescence signal intensity of tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate system for analysis of chlorpheniramine maleate in pharmaceutical formulations. Talanta2010, 82, 1999–2002.10.1016/j.talanta.2010.08.018Search in Google Scholar PubMed

Alessio, E.; Mestroni, G.; Bergamo, A.; Sava, G. Ruthenium antimetastatic agents. Curr. Top. Med. Chem. 2004, 4, 1525–1535.10.2174/1568026043387421Search in Google Scholar PubMed

Allardyce, C. S.; Dyson, P. J. Ruthenium in medicine: current clinical uses and future prospects. Platinum Metal2001, 45, 62–69.Search in Google Scholar

Allardyce, C. S.; Dyson, P. J.; Ellis, D. J.; Heath, S. L. [Ru(η⁶-p-cymene)Cl₂(PTA)] (PTA=1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells. Chem. Commun. 2001, 1396–1397.10.1039/b104021aSearch in Google Scholar

Allardyce, C. S.; Dorcier, A.; Scolaro, C.; Dyson, P. J. Development of organometallic (organo-transition metal) pharmaceuticals. Appl. Organomet. Chem. 2005, 19, 1–10.10.1002/aoc.725Search in Google Scholar

Ang, W. H.; Dyson, P. J. Classical and nonclassical ruthenium-based anticancer drugs: towards targeted chemotherapy. Eur. J. Inorg. Chem. 2006, 20, 4003–4018.10.1002/ejic.200600723Search in Google Scholar

Ang, W. H.; Daldini, E.; Scolaro, C.; Scopelliti, R.; Juillerat-Jeannerat, L.; Dyson, P. J. Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis. Inorg. Chem. 2006, 45, 9006–9013.10.1021/ic061008ySearch in Google Scholar PubMed

Ang, W. H.; De Luca, A.; Chapuis-Bernasconi, C.; Juillerat-Jeanneret, L.; Lo Bello, M.; Dyson, P. J. Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs. Chem. Med. Chem. 2007a, 2, 1799–1806.10.1002/cmdc.200700209Search in Google Scholar PubMed

Ang, W. H.; Daldini, E.; Juillerat-Jeanneret, L.; Dyson, P. J. Strategy to tether organometallic ruthenium-arene anticancer compounds to recombinant human serum albumin. Inorg. Chem. 2007b, 46, 9048–9050.10.1021/ic701474mSearch in Google Scholar PubMed

Atilla-Gokcumen, G. E.; Di Costanzo, L.; Meggers, E. Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3β. J. Biol. Inorg. Chem. 2011, 16, 45–50.10.1007/s00775-010-0699-xSearch in Google Scholar PubMed

Bacac, M.; Hotze, A. C.; van der Schilden, K.; Haasnoot, J. G.; Pacor, S.; Alessio, E.; Sava, G.; Reedijk, J. The hydrolysis of the anti-cancer ruthenium complex NAMI-A affects its DNA binding and antimetastatic activity: an NMR evaluation. J. Inorg. Biochem. 2004, 98, 402–412.10.1016/j.jinorgbio.2003.12.003Search in Google Scholar PubMed

Barragán, F.; López-Senín, P.; Salassa, L.; Betanzos-Lara, S.; Habtemariam, A.; Moreno, V.; Sadler, P. J.; Marchán, V. Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. J. Am. Chem. Soc. 2011, 133, 14098–14108.10.1021/ja205235mSearch in Google Scholar

Barry, N. P.; Sadler, P. J. Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies. Chem. Soc. Rev. 2012, 41, 264–279.10.1039/c2cs15300aSearch in Google Scholar

Barry, N. P.; Zava, O.; Furrer, J.; Dyson, P. J.; Therrien, B. Anticancer activity of opened arene ruthenium metalla-assemblies. Dalton Trans. 2010, 39, 5272–5277.10.1039/c001521kSearch in Google Scholar

Barry, N. P.; Zava, O.; Dyson, P. J.; Therrien, B. Excellent correlation between drug release and portal size in metalla-cage drug-delivery systems. Chemistry2011, 17, 9669–9677.10.1002/chem.201003530Search in Google Scholar

Beckford, F. A.; Leblanc, G.; Thessing, J.; Shaloski, M.; Frost, B. J.; Li, L.; Seeram, N. P. Organometallic ruthenium complexes with thiosemicarbazone ligands: synthesis, structure and cytotoxicity of [(η-p-cymene)Ru(NS)Cl] (NS=9-anthraldehyde thiosemicarbazones). Inorg. Chem. Commun. 2009, 12, 1094–1098.10.1016/j.inoche.2009.08.034Search in Google Scholar

Beckford, F.; Dourth, D.; Shaloski, M., Jr.; Didion, J.; Thessing, J.; Woods, J.; Crowell, V.; Gerasimchuk, N.; Gonzalez-Sarrías, A.; Seeram, N. P. Half-sandwich ruthenium-arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes. J. Inorg. Biochem. 2011, 105, 1019–1029.10.1016/j.jinorgbio.2011.04.008Search in Google Scholar

Bennett, M. A. Metal π-complexes formed by seven-membered and eight-membered carbocydic compounds. Adv. Organomet. Chem. 1966, 4, 353–387.10.1016/S0065-3055(08)60284-1Search in Google Scholar

Bennett, M. A. 7-Complexes of ruthenium and osmium containing η²-η⁶ hydrocarbon ligands: (i) complexes not containing cyclobutadiene, cyclopentadienyl or η-arene coligands. Compr. Organomet. Chem. II1995a, 7, 441–472.10.1016/B978-008046519-7.00062-9Search in Google Scholar

Bennett, M. A. 9-Complexes of ruthenium and osmium containing η²-η⁶ hydrocarbon ligands: (iii) complexes containing six-, seven- and eight-membered rings. Compr. Organomet. Chem. II1995b, 7, 549–602.10.1016/B978-008046519-7.00064-2Search in Google Scholar

Bennett, M. A. Recent advances in the chemistry of arene complexes of ruthenium(0) and ruthenium(II). Coord. Chem. Rev. 1997, 166, 225–254.10.1016/S0010-8545(97)00024-6Search in Google Scholar

Bennett, M. A.; Matheson, T. W.; Robertson, G. B.; Smith, A. K.; Tucker, P. A. Highly fluxional arene cyclooctatetraene complexes of zerovalent iron, ruthenium, and osmium. Single-crystal X-ray study of (cyclooctatetraene)(hexamethylbenzene)ruthenium(0), Ru(η⁶HMB)(1-4-η-COT). Inorg. Chem. 1980, 19, 1014–1021.10.1021/ic50206a045Search in Google Scholar

Bennett, M. A.; Matheson, T. W.; Robertson, G. B.; Smith, A. K.; Tucker, P. A. Protonation of arene cyclooctatetraene complexes of zerovalent ruthenium. Single-crystal X-ray study of the isomeric cyclooctatrienyl complexes [Ru(1-5-η-C₈H₉)(1,3,5-C₆H₃Me₃)]PF₆ and [Ru(1-3:6-7-η-C₈H₉)(1,3,5-C₆H₃Me₃)]PF₆. Inorg. Chem. 1981, 20, 2353–2365.10.1021/ic50222a001Search in Google Scholar

Bennett, M. A.; McMahon, I. J.; Pelling, S.; Robertson, G. B.; Wickramasinghe, W. A. Protonation of dicyclopentadiene complexes of ruthenium(0), osmium(0), rhodium(I), and iridium(I). Single-crystal X-ray study of [Os(2,3,5-η-C₁₀H₁₃)(η-C₆H₃Me₃-1,3,5)]PF₆, a complex containing a osmium-hydrogen-carbon interaction. Organometallics1985, 4, 754–761.10.1021/om00123a024Search in Google Scholar

Bennett, M. A.; Neumann, H.; Thomas, M.; Wang, X. Q.; Pertici, P.; Salvadori, P.; Vitulli, G. (η⁶-Naphthalene)(η⁴-1,5-cyclooctadiene)ruthenium(0): efficient synthesis, chemistry and catalytic properties. Organometallics1991a, 10, 3237–3245.10.1021/om00055a047Search in Google Scholar

Bennett, M. A.; Pelling, S.; Robertson, G. B.; Wickramasinghe, W. A. Synthesis and fluxional behavior of protonated 1,3-diene complexes of ruthenium(0), osmium(0), rhodium(I), and iridium(I) containing 2,3-dimethylene-5,6,7,8-dibenzobicyclo[2.2.2]octane (ddbo, C₁₈H₁₄). Single-crystal X-ray study of the agostic complex [Ru(C₁₈H₁₅)(η-C₆H₃Me₃)]PF₆. Organometallics1991b, 10, 2166–2172.10.1021/om00053a019Search in Google Scholar

Bennett, M. A.; Goh, L. Y.; McMahon, I. J.; Mitchell, T. R. B.; Robertson, G. B.; Turney, T. W.; Wasantha, W. A. Double deprotonation of ruthenium(II) cations containing 1,2-dimethyl-substituted η⁶-arenes. Protonation of the resulting exo-coordinated (o-xylylene)ruthenium(0) complexes and X-ray crystal structures of the agostic (η³-pentamethylbenzyl)ruthenium(II) complexes [Ru{η³-(HCH₂)(CH₂)C₆Me₄}{(Z)-Ph₂PCH:CHPPh₂}(PMe₂Ph)]PF₆ and [Ru{η³-(HCH₂)(CH₂)C₆Me₄}(PMe₂Ph)₃]PF₆. Organometallics1992, 11, 3069–3085.10.1021/om00045a022Search in Google Scholar

Bennett, M. A.; Khan, K.; Wenger, E. 8-Complexes of ruthenium and osmium containing η²-η⁶ hydrocarbon ligands: (ii) complexes containing four- and five-membered rings (including MCp (arene) (complexes). Compr. Organomet. Chem. II1995, 7, 473–548.10.1016/B978-008046519-7.00063-0Search in Google Scholar

Bennett, M. A.; Goh, L. Y.; Willis, A. C. Base-induced fragmentation of a macrocyclic thioether at an (arene)ruthenium(II) center. Generation of η¹(S)-ethenethiolate and η²(C,S)-thioacetaldehyde. J. Am. Chem. Soc. 1996a, 118, 4984–4992.10.1021/ja9541084Search in Google Scholar

Bennett, M. A.; Willis, A. C.; Goh, L. Y.; Chen, W. Divalent ruthenium complexes containing 1,4,7-trithiacyclononane and cycloocta-1,5-diene (C₈H₁₂) or 1-3:5,6η-cyclooctadienyl (C₈H₁₁). Polyhedron1996b, 15, 3559–3567.10.1016/0277-5387(96)00073-3Search in Google Scholar

Bennett, M. A.; Neumann, H.; Willis, A. C.; Ballantini, V.; Pertici, P.; Mann, B. E. Synthesis, structure, and fluxional behavior of bis(cyclooctatetraene)ruthenium(0) and its derivatives. Organometallics1997, 16, 2868–2878.10.1021/om970065jSearch in Google Scholar

Bennett, M. A.; Bown, M.; Byrnes, M. J. Thermally induced endo to exo isomerization in the o-xylylene complexes of zerovalent ruthenium and osmium, M(η⁶-C₆Me₆){η⁴-o-(CH₂)₂C₆Me₄} (M=Ru, Os). J. Organomet. Chem. 1998a, 571, 139–144.10.1016/S0022-328X(98)00900-0Search in Google Scholar

Bennett, M. A.; Lu, Z.; Wang, X.; Bown, M.; Hockless, D. C. R. Ligand-induced ring slippage of η⁶- to η⁴-naphthalene. Preparation and structural characterization of Ru(η⁴-C₁₀H₈)(η⁴-1,5-C₈H₁₂)(L) [L=PMe₃, PEt₃, P(OMe)₃] and of derived binuclear complexes containing bridging naphthalene, Ru₂(μ-η⁶:η⁴-C₁₀H₈)(η⁴-1,5-C₈H₁₂)₂(L) [L=PEt₃, P(OMe)₃]. J. Am. Chem. Soc. 1998b, 120, 10409–10415.10.1021/ja981027+Search in Google Scholar

Bennett, M. A.; Clark, A. M.; Contel, M.; Rickard, C. E. F.; Roper, W. R.; Wright, L. J. Cyclometallated complexes of ruthenium and osmium containing the o-C₆H₄PPh₂ ligand. J. Organomet. Chem. 2000, 601, 299–304.10.1016/S0022-328X(00)00086-3Search in Google Scholar

Bennett, M. A.; Edwards, A. J.; Harper, J. R.; Khimyak, T.; Willis, A. C. Synthesis, structure and redox behaviour of tethered arene-ruthenium(II) complexes. J. Organomet. Chem. 2001, 629, 7–18.10.1016/S0022-328X(01)00801-4Search in Google Scholar

Bennett, M. A.; Byrnes, M. J.; Chung, G.; Edwards, A. J.; Willis, A. C. Bis(acetylacetonato)ruthenium(II) complexes containing bulky tertiary phosphines. Formation and redox behaviour of Ru(acac)₂ (PR₃) (R=iPr, Cy) complexes with ethene, carbon monoxide, and bridging dinitrogen. Inorg. Chim. Acta2005, 358, 1692–1708.10.1016/j.ica.2004.07.062Search in Google Scholar

Bergamo, A.; Sava, G. Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs. Dalton Trans. 2011, 40, 7817–7823.10.1039/c0dt01816cSearch in Google Scholar PubMed

Bergamo, A.; Gava, B.; Alessio, E.; Mestroni, G.; Serli, B.; Cocchietto, M.; Zorzet, S.; Sava, G. Ruthenium-based NAMI-A type complexes with in vivo selective metastasis reduction and in vitro invasion inhibition unrelated to cell cytotoxicity. Int. J. Oncol. 2002, 21, 1331–1338.10.3892/ijo.21.6.1331Search in Google Scholar

Bergamo, A.; Masi, A.; Dyson, P. J.; Sava, G. Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound. Int. J. Oncol. 2008, 33, 1281–1289.10.3892/ijo_00000119Search in Google Scholar

Bergamo, A.; Gaiddon, C.; Schellens, J. H.; Beijnen, J. H.; Sava, G. Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates. J. Inorg. Biochem. 2012, 106, 90–99.10.1016/j.jinorgbio.2011.09.030Search in Google Scholar PubMed

Berger, I.; Hanif, M.; Nazarov, A. A.; Hartinger, C. G.; John, R. O.; Kuznetsov, M. L.; Groessl, M.; Schmitt, F.; Zava, O.; Biba, F.; Arion, V. B.; Galanski, M.; Jakupec, M. A.; Juillerat-Jeanneret, L.; Dyson, P. J.; Keppler, B. K. In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands. Chem. Eur. J. 2008, 14, 9046–9057.10.1002/chem.200801032Search in Google Scholar PubMed

Betanzos-Lara, S.; Salassa, L.; Habtemariam, A.; Novakova, O.; Pizarro, A. M.; Clarkson, G. J.; Liskova, B.; Brabec, V.; Sadler, P. J. Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics2012, 31, 3466–3479.10.1021/om201177ySearch in Google Scholar

Bhat, S. S.; Kumbhar, A. S.; Kumbhar, A. A.; Khan, A. Efficient DNA condensation induced by ruthenium(II) complexes of a bipyridine-functionalized molecular clip ligand. Chemistry2012, 18, 16383–16392.10.1002/chem.201200407Search in Google Scholar PubMed

Biersack, B.; Zoldakova, M.; Effenberger, K.; Schobert, R. (arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells. Eur. J. Med. Chem. 2010, 45, 1972–1975.10.1016/j.ejmech.2010.01.040Search in Google Scholar PubMed

Bíró, L.; Farkas, E.; Buglyó, P. Complex formation between [Ru(η)6(-p-cym)(H₂O)₃]²⁺ and (O,O) donor ligands with biological relevance in aqueous solution. Dalton Trans. 2010, 39, 10272–10278.10.1039/c0dt00469cSearch in Google Scholar PubMed

Bíró, L.; Farkas, E.; Buglyó, P. Hydrolytic behaviour and chloride ion binding capability of [Ru(η⁶-p-cym)(H₂O)₃]²⁺: a solution equilibrium study. Dalton Trans. 2012, 41, 285–291.10.1039/C1DT11405KSearch in Google Scholar PubMed

Blagosklonny, M. V. Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle2004, 3, 1035–1042.10.4161/cc.3.8.1023Search in Google Scholar

Blagosklonny, M. V. How cancer could be cured by 2015. Cell Cycle2005, 4, 269–278.10.4161/cc.4.2.1493Search in Google Scholar

Blasberg, F.; Bats, J. W.; Bolte, M.; Lerner, H.-W.; Wagner, M. Para-quinone-containing bis(pyrazol-1-yl)methane ligands: coordination behavior toward CoII and a C-H activation reaction with CeIV. Inorg. Chem. 2010, 49, 7435–7445.10.1021/ic100754kSearch in Google Scholar PubMed

Bolink, H. J.; Cappelli, L.; Coronado, E.; Gaviña, P. Observation of electroluminescence at room temperature from a ruthenium(II) bis-terpyridine complex and its use for preparing light-emitting electrochemical cells. Inorg. Chem. 2005, 44, 5966–5968.10.1021/ic0507058Search in Google Scholar PubMed

Boutadla, Y.; Davies, D. L.; Jones, R. C.; Singh, K. The scope of ambiphilic acetate-assisted cyclometallation with half-sandwich complexes of iridium, rhodium and ruthenium. Chemistry2011, 17, 3438–3448.10.1002/chem.201002604Search in Google Scholar PubMed

Bratsos, I.; Birarda, G.; Jedner, S.; Zangrando, E.; Alessio, E. Half-sandwich RuII-[9]aneS3 complexes with dicarboxylate ligands: synthesis, characterization and chemical behavior. Dalton Trans. 2007, 4048–4058.10.1039/b707011jSearch in Google Scholar PubMed

Bratsos, I.; Jedner, S.; Bergamo, A.; Sava, G.; Gianferrara, T.; Zangrando, E.; Alessio, E. Half-sandwich Ru II[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: preparation, structural characterization and in vitro cytotoxic activity. J. Inorg. Biochem. 2008, 102, 1120–1133.10.1016/j.jinorgbio.2008.01.005Search in Google Scholar PubMed

Bratsos, I.; Urankar, D.; Zangrando, E.; Genova-Kalou, P.; Košmrlj, J.; Alessio, E.; Turel, I. 1-(2-Picolyl)-substituted 1,2,3-triazole as novel chelating ligand for the preparation of ruthenium complexes with potential anticancer activity. Dalton Trans. 2011, 40, 5188–5199.10.1039/c0dt01807dSearch in Google Scholar PubMed

Bratsos, I.; Mitri, E.; Ravalico, F.; Zangrando, E.; Gianferrara, T.; Bergamo, A.; Alessio, E. New half sandwich Ru(II) coordination compounds for anticancer activity. Dalton Trans. 2012, 41, 7358–7371.10.1039/c2dt30654aSearch in Google Scholar PubMed

Bregman, H.; Meggers, E. Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety. Org. Lett. 2006, 8, 5465–5468.10.1021/ol0620646Search in Google Scholar PubMed

Brindell, M.; Kuliś, E.; Elmroth, S. K.; Urbańska, K.; Stochel, G. Light-induced anticancer activity of [RuCl₂(DMSO)₄] complexes. J. Med. Chem. 2005, 48, 7298–7304.10.1021/jm0502992Search in Google Scholar PubMed

Bruijnincx, P. C. A.; Sadler, P. J. New trends for metal complexes with anticancer activity. Curr. Opin. Chem. Bio. 2008, 12, 197–206.10.1016/j.cbpa.2007.11.013Search in Google Scholar PubMed PubMed Central

Bugarcic, T.; Habtemariam, A.; Stepankova, J.; Heringova, P.; Kasparkova, J.; Deeth, R. J.; Johnstone, R. D.; Prescimone, A.; Parkin, A.; Parsons, S.; Brabec, V.; Sadler, P. J. The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorg. Chem. 2008, 47, 11470–11486.10.1021/ic801361mSearch in Google Scholar PubMed

Bugarcic, T.; Habtemariam, A.; Deeth, R. J.; Fabbiani, F. P. A.; Parsons, S.; Sadler, P. J. Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorg. Chem. 2009, 48, 9444–9453.10.1021/ic9013366Search in Google Scholar PubMed

Buglyó, P.; Farkas, E. Novel half-sandwich Ru(II)-hydroxamate complexes: synthesis, characterization and equilibrium study in aqueous solution. Dalton Trans. 2009, 8063–8070.10.1039/b908173aSearch in Google Scholar PubMed

Burns, I. D.; Hill, A. F.; White, A. J. P.; Williams, D. J.; Wilton-Ely, J. D. E. T. Polyazolyl chelate chemistry. 6.1 Bidentate coordination of HB(pz)₃ (pz=pyrazol-1-yl) to ruthenium and osmium: crystal structure of [RuH(CO)(PPh₃)₂{κ₂-HB(pz)₃}]. Organometallics1998, 17, 1552–1557.10.1021/om970991ySearch in Google Scholar

Byabartta, P.; Jasimuddin, S. K.; Mostafa, G.; Lu, T.-H.; Sinha, C. The synthesis, spectral studies and electrochemistry of 1,10-(phenanthroline)-bis-{1-alkyl-2-(arylazo)imidazole}ruthenium(II) perchlorate. Single crystal X-ray structure of [Ru(phen)(HaaiMe)₂](ClO₄)₂ [phen=1,10-phenanthroline, HaaiMe=1-methyl-2-(phenylazo)imidazole]. Polyhedron2003, 22, 849–859.10.1016/S0277-5387(03)00004-4Search in Google Scholar

Cabrera, E.; Cerecetto, H.; González, M.; Gambino, D.; Noblia, P.; Otero, L.; Parajón-Costa, B.; Anzellotti, A.; Sánchez-Delgado, R.; Azqueta, A.; López de Ceráin, A.; Monge, A. Ruthenium(II) nitrofurylsemicarbazone complexes: new DNA binding agents. Eur. J. Med. Chem. 2004, 39, 377–382.10.1016/j.ejmech.2004.01.002Search in Google Scholar PubMed

Camm, K. D.; El-Sokkary, A.; Gott, A. L.; Stockley, P. G.; Belyaeva, T.; McGowan, P. C. Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents. Dalton Trans. 2009, 10914–10925.10.1039/b918902eSearch in Google Scholar PubMed

Canivet, J.; Karmazin-Brelot, L.; Süss-Fink, G. Cationic arene ruthenium complexes containing chelating 1,10-phenanthroline ligands. J. Organomet. Chem. 2005, 690, 3202–3211.10.1016/j.jorganchem.2005.02.050Search in Google Scholar

Caruso, F.; Rossi, M.; Benson, A.; Opazo, C.; Freedman, D.; Monti, E.; Gariboldi, M. B.; Shaulky, J.; Marchetti, F.; Pettinari, R.; Pettinari, C. Ruthenium-arene complexes of curcumin: X-ray and density functional theory structure, synthesis, and spectroscopic characterization, in vitro antitumor activity, and DNA docking studies of (p-cymene)Ru(curcuminato)chloro. J. Med. Chem. 2012, 55, 1072–1081.10.1021/jm200912jSearch in Google Scholar PubMed

Casini, A.; Mastrobuoni, G.; Ang, W. H.; Gabbiani, C.; Pieraccini, G.; Moneti, G.; Dyson, P. J.; Messori, L. ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes. Chem. Med. Chem. 2007, 2, 631–635.10.1002/cmdc.200600258Search in Google Scholar PubMed

Casini, A.; Gabbiani, C.; Sorrentino, F.; Rigobello, M. P.; Bindoli, A.; Geldbach, T. J.; Marrone, A.; Re, N.; Hartinger, C. G.; Dyson, P. J.; Messori, L. Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds. J. Med. Chem. 2008, 51, 6773–6781.10.1021/jm8006678Search in Google Scholar PubMed

Casini, A.; Gabbiani, C.; Michelucci, E.; Pieraccini, G.; Moneti, G.; Dyson, P. J.; Messori, L. Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound. J. Biol. Inorg. Chem. 2009a, 14, 761–770.10.1007/s00775-009-0489-5Search in Google Scholar PubMed

Casini, A.; Karotki, A.; Gabbiani, C.; Rugi, F.; Vašák, M.; Messori, L.; Dyson, P. J. Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action. Metallomics2009b, 1, 434–441.10.1039/b909185hSearch in Google Scholar PubMed

Castellano-Castillo, M.; Kostrhunova, H.; Marini, V.; Kasparkova, J.; Sadler, P. J.; Malinge, J. M.; Brabec, V. Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. J. Biol. Inorg. Chem. 2008, 13, 993–999.10.1007/s00775-008-0386-3Search in Google Scholar

Chatterjee, S.; Kundu, S.; Bhattacharyya, A.; Hartinger, C. G.; Dyson, P. J. The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways. J. Biol. Inorg. Chem. 2008, 13, 1149–1155.10.1007/s00775-008-0400-9Search in Google Scholar

Chavain, N.; Biot, C. Organometallic complexes: new tools for chemotherapy. Curr. Med. Chem. 2010, 17, 2729–2745.10.2174/092986710791859306Search in Google Scholar

Chelopo, M. P.; Pawar, S. A.; Sokhela, M. K.; Govender, T.; Kruger, H. G.; Maguire, G. E. M. Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands. Eur. J. Med. Chem. 2013, 407–414.10.1016/j.ejmech.2013.05.048Search in Google Scholar

Chen, X.-M.; Wu, G.-H.; Chen, J.-M.; Jiang, Y.-Q.; Chen, G.-N.; Oyama, M.; Chen, X.; Wang, X.-R. A novel electrochemiluminescence sensor based on bis(2,2′-bipyridine)-5-amino-1,10-phenanthroline ruthenium(II) covalently combined with graphite oxide. Biosens. Bioelectron. 2010, 26, 872–876.10.1016/j.bios.2010.07.083Search in Google Scholar

Chval, Z.; Futera, Z.; Burda, J. V. Comparison of hydration reactions for “piano-stool” RAPTA-B and [Ru(η⁶-arene)(en)Cl]⁺ complexes: density functional theory computational study. J. Chem. Phys. 2011, 134, 024520.10.1063/1.3515534Search in Google Scholar

Ciancetta, A.; Genheden, S.; Ryde, U. A QM/MM study of the binding of RAPTA ligands to cathepsin B. J. Comput. Aided Mol. Des. 2011, 25, 729–742.10.1007/s10822-011-9448-7Search in Google Scholar

Cini, R.; Tamasi, G.; Defazio, S.; Corsini, M.; Zanello, P.; Messori, L.; Marcon, G.; Piccioli, F.; Orioli, P. Study of ruthenium(II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agents. Inorg. Chem. 2003, 42, 8038–8052.10.1021/ic0349095Search in Google Scholar

Concepcion, J.; Loeb, B.; Simon-Manso, Y.; Zuloaga, F. Influence of L-type ligands on the relative stability and interconversion of cis-trans-[Ru(phen)₂L₂]ⁿ⁺ type complexes. A theoretical study. Polyhedron2000, 19, 2297–2302.10.1016/S0277-5387(00)00492-7Search in Google Scholar

Corral, E.; Hotze, A. C.; den Dulk, H.; Leczkowska, A.; Rodger, A.; Hannon, M. J.; Reedijk, J. Ruthenium polypyridyl complexes and their modes of interaction with DNA: is there a correlation between these interactions and the antitumor activity of the compounds? J. Biol. Inorg. Chem. 2009, 14, 439–348.10.1007/s00775-008-0460-xSearch in Google Scholar PubMed PubMed Central

Cutillas, N.; Yellol, G. S.; de Haro, C.; Vicente, C.; Rodríguez, V.; Ruiz, J. Anticancer cyclometalated complexes of platinum group metals and gold. Coord. Chem. Rev. 2013, 257, 2784–2797.10.1016/j.ccr.2013.03.024Search in Google Scholar

Das, S.; Sinha, S.; Britto, R.; Somasundaram, K.; Samuelson, A. G. Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action. J. Inorg. Biochem. 2010, 104, 93–104.10.1016/j.jinorgbio.2009.09.017Search in Google Scholar PubMed

David, S.; Perkins, R. S.; Fronczek, F. R.; Kasiri, S.; Mandal, S. S.; Srivastava, R. S. Synthesis, characterization, and anticancer activity of ruthenium-pyrazole complexes. J. Inorg. Biochem. 2012, 111, 33–39.10.1016/j.jinorgbio.2012.02.022Search in Google Scholar PubMed

Debreczeni, J. E.; Bullock, A. N.; Atilla, G. E.; Williams, D. S.; Bregman, H.; Knapp, S.; Meggers, E. Ruthenium half-sandwich complexes bound to protein kinase Pim-1. Angew Chem. Int. Ed. Engl. 2006, 45, 1580–1585.10.1002/anie.200503468Search in Google Scholar PubMed

Deubel, D. V.; Lau, J. K. In silico evolution of substrate selectivity: comparison of organometallic ruthenium complexes with the anticancer drug cisplatin. Chem. Commun. (Camb.) 2006, 2451–2453.10.1039/b601590eSearch in Google Scholar PubMed

Dorcier, A.; Hartinger, C. G.; Scopelliti, R.; Fish, R. H.; Keppler, B. K.; Dyson, P. J. Studies on the reactivity of organometallic Ru-, Rh- and Os-PTA complexes with DNA model compounds. J. Inorg. Biochem. 2008, 102, 1066–1076.10.1016/j.jinorgbio.2007.10.016Search in Google Scholar PubMed

Dougan, S. J.; Melchart, M.; Habtemariam, A.; Parsons, S.; Sadler, P. J. Phenylazo-pyridine and phenylazo-pyrazole chlorido ruthenium(II) arene complexes: arene loss, aquation, and cancer cell cytotoxicity. Inorg. Chem. 2006, 45, 10882–10894.10.1021/ic061460hSearch in Google Scholar PubMed

Dougan, S. J.; Habtemariam, A.; McHale, S. E.; Parsons, S.; Sadler, P. J. Catalytic organometallic anticancer complexes. Proc. Natl. Acad. Sci. USA2008, 105, 11628–11633.10.1073/pnas.0800076105Search in Google Scholar PubMed PubMed Central

Dutta, B.; Scolaro, C.; Scopelliti, R.; Dyson, P. J.; Severin, K. Importance of the π-ligand: remarkable effect of the cyclopentadienyl ring on the cytotoxicity of ruthenium PTA compounds. Organometallics2008a, 27, 1355–1357.10.1021/om800025aSearch in Google Scholar

Dutta, B.; Scopelliti, R.; Severin, K. Synthesis, structure, and reactivity of the methoxy-bridged dimer [Cp∧Ru(μ-OMe)]₂ (Cp∧) η⁵-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl). Organometallics2008b, 27, 423–429.10.1021/om700992dSearch in Google Scholar

Dutta, B.; Curchod, B. F.; Campomanes, P.; Solari, E.; Scopelliti, R.; Rothlisberger, U.; Severin, K. Reactions of alkynes with [RuCl(cyclopentadienyl)] complexes: the important first steps. Chemistry2010, 16, 8400–8409.10.1002/chem.201000855Search in Google Scholar PubMed

Egger, A. E.; Hartinger, C. G.; Renfrew, A. K.; Dyson, P. J. Metabolization of [Ru(η⁶-C₆H₅CF₃)(PTA)Cl₂]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand. J. Biol. Inorg. Chem. 2010, 15, 919–927.10.1007/s00775-010-0654-xSearch in Google Scholar PubMed

Etienne, S.; Beley, M. Preparation and study of ruthenium(II) 2,2′:6′,2″-terpyridine complexes linked by an O-CH₂ spacer to thiophene moieties. Inorg. Chem. Comm., 2006, 9, 68–71.10.1016/j.inoche.2005.10.004Search in Google Scholar

Fernández, R.; Melchart, M.; Habtemariam, A.; Parsons, S.; Sadler, P. J. Use of chelating ligands to tune the reactive site of half-sandwich ruthenium(II)-arene anticancer complexes. Chemistry2004, 10, 5173–5179.10.1002/chem.200400640Search in Google Scholar PubMed

Fetzer, L.; Boff, B.; Ali, M.; Xiangjun, M.; Collin, J. P.; Sirlin, C.; Gaiddon, C.; Pfeffer, M. Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier. Dalton Trans. 2011, 40, 8869–8878.10.1039/c1dt10322aSearch in Google Scholar PubMed

Fu, Y.; Habtemariam, A.; Basri, A. M.; Braddick, D.; Clarkson, G. J.; Sadler, P. J. Structure-activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Trans. 2011, 40, 10553–10562.10.1039/c1dt10937eSearch in Google Scholar PubMed

Furrer, M. A.; Schmitt, F.; Wiederkehr, M.; Juillerat-Jeanneret, L.; Therrien, B. Cellular delivery of pyrenyl-arene ruthenium complexes by a water-soluble arene ruthenium metalla-cage. Dalton Trans. 2012, 41, 7201–7211.10.1039/c2dt30193hSearch in Google Scholar PubMed

Futera, Z.; Klenko, J.; Sponer, J. E.; Sponer, J.; Burda, J. V. Interactions of the “piano-stool” [ruthenium(II) (η⁶-arene)(en)CL]⁺ complexes with water and nucleobases; ab initio and DFT study. J. Comput. Chem. 2009, 30, 1758–1770.10.1002/jcc.21179Search in Google Scholar PubMed

Galindo, M. A.; Quirós, M.; Romero, M. A.; Navarro, J. A. Cyclic tetranuclear half-sandwich ruthenium(II) complexes with 4,7-phenanthroline and hydroxo bridges: crystal structure, solution behaviour and binding to nucleosides. J. Inorg. Biochem. 2008, 102, 1025–1032.10.1016/j.jinorgbio.2007.11.009Search in Google Scholar PubMed

Garcıa-Fernandez, A.; Dıez, J.; Manteca, A.; Sanchez, J.; Gamasa, M. P.; Lastra, E. Novel hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the water-soluble phosphane 1,3,5-triaza-7-phosphaadamantane: synthesis and evaluation of DNA binding properties. Polyhedron2008, 27, 1214–1228.10.1016/j.poly.2007.12.013Search in Google Scholar

García-Fernandez, A.; Díez, J.; Gamasa, M. P.; Lastra, E. Facile modification of 1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane phosphanes coordinated to ruthenium(II). Inorg. Chem. 2009, 48, 2471–2481.10.1021/ic801710ySearch in Google Scholar PubMed

García-Fernández, A.; Díez, J.; Manteca, A.; Sánchez, J.; García-Navas, R.; Sierra, B. G.; Mollinedo, F.; Gamasa, M. P.; Lastra, E. Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the phosphanes PTA and 1-CH3-PTA. Dalton Trans. 2010, 39, 10186–10196.10.1039/c0dt00206bSearch in Google Scholar PubMed

Gasser, G.; Ott, I.; Metzler-Nolte, N. Organometallic anticancer compounds. J. Med. Chem. 2011, 54, 3–25.10.1021/jm100020wSearch in Google Scholar PubMed PubMed Central

Gaur, R.; Mishra, L. Synthesis and characterization of Ru(II)-DMSO-Cl-chalcone complexes: DNA binding, nuclease, and topoisomerase II inhibitory activity. Inorg. Chem. 2012, 51, 3059–3070.10.1021/ic202440rSearch in Google Scholar PubMed

Gauthier, S.; Solari, E.; Dutta, B.; Scopelliti, R.; Severin, K. A new coupling reaction for the synthesis of ruthenium half-sandwich complexes with sterically demanding cyclopentadienyl ligands. Chem. Commun. (Camb.) 2007, 1837–1839.10.1039/b618712aSearch in Google Scholar PubMed

Gianferrara, T.; Bratsos, I.; Iengo, E.; Milani, B.; Ostrić, A.; Spagnul, C.; Zangrando, E.; Alessio, E. Synthetic strategies towards ruthenium-porphyrin conjugates for anticancer activity. Dalton Trans. 2009, 10742–10756.10.1039/b911393bSearch in Google Scholar PubMed

Giannini, F.; Suss-Fink, G.; Furrer, J. Efficient oxidation of cysteine and glutathione catalyzed by a dinuclear areneruthenium trithiolato anticancer complex. Inorg. Chem. 2011, 50, 10552–10554.10.1021/ic201941jSearch in Google Scholar PubMed

Giannini, F.; Geiser, L.; Paul, L. E. H.; Roder, T.; Therrien, B.; Suss-Fink, G.; Furrer, J. Tuning the in vitro cell cytotoxicity of dinuclear arene ruthenium trithiolato complexes: influence of the arene ligand. J. Organomet. Chem. 2014, 783, 40–46.10.1016/j.jorganchem.2015.02.010Search in Google Scholar

Giannini, F.; Bartoloni, M.; Paul, L. E. H.; Süss-Fink, G.; Reymond, J.-L.; Furrer, J. Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Med. Chem. Commun. 2015, 6, 347–350.10.1039/C4MD00433GSearch in Google Scholar

Giovagnini, L.; Sitran, S.; Castagliuolo, I.; Brun, P.; Corsini, M.; Zanello, P.; Zoleo, A.; Maniero, A.; Biondi, B.; Fregona, D. Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity. Dalton Trans. 2008, 6699–6708.10.1039/b806341aSearch in Google Scholar PubMed

Gligorijević, N.; Aranđelović, S.; Filipović, L.; Jakovljević, K.; Janković, R.; Grgurić-Šipka, S.; Ivanović, I.; Radulović, S.; Tešić, Z. L. j. Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: comparison to a series of ruthenium(II)-arene complexes with similar structure. J. Inorg. Biochem. 2012, 108, 53–61.10.1016/j.jinorgbio.2011.12.002Search in Google Scholar

Gollas, B.; Speiser, B.; Zagos, I.; Maichle-Mossmer, C. Electrochemistry of ruthenium metallocenes Part 3. Synthesis and properties of ruthenium paracyclophane complexes with methacrylic acid and methacrylate ester substituents. J. Organomet. Chem. 2000, 602, 75–90.10.1016/S0022-328X(00)00121-2Search in Google Scholar

Gopal, Y. N. V.; Jayaraju, D.; Kondapi, A. K. Inhibition of topoisomerase II catalytic activity by two ruthenium compounds: a ligand-dependent mode of action. Biochemistry1999, 38, 4382–4388.10.1021/bi981990sSearch in Google Scholar

Gossens, C.; Tavernelli, I.; Rothlisberger, U. DNA structural distortions induced by ruthenium-arene anticancer compounds. J. Am. Chem. Soc. 2008, 130, 10921–10928.10.1021/ja800194aSearch in Google Scholar

Goze, C.; Sabatini, C.; Barbieri, A.; Barigelletti, F.; Ziessel, R. Ruthenium-terpyridine complexes with multiple ethynylpyrenyl or ethynyltoluyl subunits: X-ray structure, redox, and spectroscopic properties. Inorg. Chem. 2007, 46, 7341–7350.10.1021/ic070149cSearch in Google Scholar

Gras, M.; Therrien, B.; Süss-Fink, G.; Zava, O.; Dyson, P. J. Thiophenolato-bridged dinuclear arene ruthenium complexes: a new family of highly cytotoxic anticancer agents. Dalton Trans. 2010, 39, 10305–10313.10.1039/c0dt00887gSearch in Google Scholar

Grguric-Sipka, S. R.; Vilaplana, R. A.; Pérez, J. M.; Fuertes, M. A.; Alonso, C.; Alvarez, Y.; Sabo, T. J.; González-Vílchez, F. Synthesis, characterization, interaction with DNA and cytotoxicity of the new potential antitumour drug cis-K[Ru(eddp)Cl(2)]. J. Inorg. Biochem. 2003, 97, 215–220.10.1016/S0162-0134(03)00281-2Search in Google Scholar

Grgurić-Sipka, S.; Ivanović, I.; Rakić, G.; Todorović, N.; Gligorijević, N.; Radulović, S.; Arion, V. B.; Keppler, B. K.; Tesić, Z. L. j. Ruthenium(II)-arene complexes with functionalized pyridines: synthesis, characterization and cytotoxic activity. Eur. J. Med. Chem. 2010, 45, 1051–1058.10.1016/j.ejmech.2009.11.055Search in Google Scholar PubMed

Groessl, M.; Hartinger, C. G.; Dyson, P. J.; Keppler, B. K. CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP. J. Inorg. Biochem. 2008, 102, 1060–1065.10.1016/j.jinorgbio.2007.11.018Search in Google Scholar PubMed

Groessl, M.; Tsybin, Y. O.; Hartinger, C. G.; Keppler, B. K.; Dyson, P. J. Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry. J. Biol. Inorg. Chem. 2009, 15, 677–688.10.1007/s00775-010-0635-0Search in Google Scholar PubMed PubMed Central

Gu, S.; Liu, B.; Chen, J.; Wu, H.; Chen, W. Synthesis, structures, and properties of ruthenium(II) complexes of N-(1,10-phenanthrolin-2-yl)imidazolylidenes. Dalton Trans. 2012, 41, 962–970.10.1039/C1DT11269DSearch in Google Scholar

Gupta, G.; Nowak-Sliwinska, P.; Herrero, N.; Dyson, P. J.; Therrien, B. Highly water soluble trithiolato-bridged dinuclear arene ruthenium complexes. Inorg. Chim. Acta2015, 423, 524–529.10.1016/j.ica.2014.09.013Search in Google Scholar

Habtemariam, A.; Melchart, M.; Fernandez, R.; Parsons, S.; Oswald, I. D.; Parkin, A.; Fabbiani, F. P.; Davidson, J. E.; Dawson, A.; Aird, R. E.; Jodrell, D. I.; Sadler, P. J. Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. J. Med. Chem. 2006, 49, 6858–6868.10.1021/jm060596mSearch in Google Scholar PubMed

Han, Y. F.; Jia, W. G.; Yu, W. B.; Jin, G. X. Stepwise formation of organometallic macrocycles, prisms and boxes from Ir, Rh and Ru-based half-sandwich units. Chem. Soc. Rev. 2009, 38, 3419–3434.10.1039/b901649jSearch in Google Scholar PubMed

Han, Y. F.; Li, H.; Fei, Y.; Lin, Y. J.; Zhang, W. Z.; Jin, G. X. Synthesis and structural characterization of binuclear half-sandwich iridium, rhodium and ruthenium complexes containing 4,4′-dipyridyldisulfide (4DPDS) ligands. Dalton Trans. 2010, 39, 7119–7124.10.1039/c0dt00057dSearch in Google Scholar PubMed

Hanif, M.; Henke, H.; Meier, S. M.; Martic, S.; Labib, M.; Kandioller, W.; Jakupec, M. A.; Arion, V. B.; Kraatz, H.; Keppler, B. K.; Hartinger, C. G. Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter? Inorg. Chem. 2010a, 49, 7953–7963.10.1021/ic1009785Search in Google Scholar PubMed

Hanif, M.; Nazarov, A. A.; Hartinger, C. G.; Kandioller, W.; Jakupec, M. A.; Arion, V. B.; Dyson, P. J.; Keppler, B. K. Osmium(II)- versus ruthenium(II)-arene carbohydrate-based anticancer compounds: similarities and differences. Dalton Trans. 2010b, 39, 7345–7352.10.1039/c003085fSearch in Google Scholar PubMed

Hanif, M.; Meier, S. M.; Kandioller, W.; Bytzek, A.; Hejl, M.; Hartinger, C. G.; Nazarov, A. A.; Arion, V. B.; Jakupec, M. A.; Dyson, P. J.; Keppler, B. K. From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands. J. Inorg. Biochem. 2011, 105, 224–231.10.1016/j.jinorgbio.2010.10.004Search in Google Scholar PubMed

Hanif, M.; Nazarov, A. A.; Legin, A.; Groessl, M.; Arion, V. B.; Jakupec, M. A.; Tsybin, Y. O.; Dyson, P. J.; Keppler, B. K.; Hartinger, C. G. Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules. Chem. Commun. (Camb.) 2012, 48, 1475–1477.10.1039/C1CC14713GSearch in Google Scholar

Hannon, M. J. Metal-based anticancer drugs: from a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biology. Pure Appl. Chem. 2007, 79, 2243–2261.10.1351/pac200779122243Search in Google Scholar

Hara, K.; Sugihara, H.; Tachibana, Y.; Islam, A.; Yanagida, M.; Sayama, K.; Arakawa, H. Dye-sensitized nanocrystalline TiO₂ solar cells based on ruthenium(II) phenanthroline complex photosensitizers. Langmuir2001, 17, 5992–5999.10.1021/la010343qSearch in Google Scholar

Hartinger, C. G.; Casini, A.; Duhot, C.; Tsybin, Y. O.; Messori, L.; Dyson, P. J. Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: relevance to antitumour activity. J. Inorg. Biochem. 2008, 102, 2136–2141.10.1016/j.jinorgbio.2008.08.002Search in Google Scholar

Heffeter, P.; Bock, K.; Atil, B.; Hoda, M. A. R.; Korner, W.; Bartel, C.; Jungwirth, U.; Keppler, B. K.; Micksche, M.; Berger, W.; Koellensperger, G. Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339. J. Biol. Inorg. Chem. 2010, 15, 737–748.10.1007/s00775-010-0642-1Search in Google Scholar

Helena, G. M.; Morais, T. S.; Florindo, P.; Piedade, M. F.; Moreno, V.; Ciudad, C.; Noe, V. Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands. J. Inorg. Biochem. 2009, 103, 354–361.10.1016/j.jinorgbio.2008.11.016Search in Google Scholar

Henke, H.; Kandioller, W.; Hanif, M.; Keppler, B. K.; Hartinger, C. G. Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents. Chem. Biodivers. 2012, 9, 1718–1727.10.1002/cbdv.201200005Search in Google Scholar

Herberhold, M.; Yan, H.; Milius, W.; Wrackmeyer, B. Metal-induced B-H activation: addition of methyl acetylene carboxylates to Cp*Rh-, Cp*Ir-, (p-cymene)Ru-, and (p-cymene)Os half-sandwich complexes containing the chelating 1,2-dicarba-closo-dodecaborane-1,2-dithiolate ligand. Chemistry2000, 6, 3026–3032.10.1002/1521-3765(20000818)6:16<3026::AID-CHEM3026>3.0.CO;2-VSearch in Google Scholar

Herman, A.; Tanski, J. M.; Tibbetts, M. F.; Anderson, C. M. Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex. Inorg. Chem. 2008, 47, 274–280.10.1021/ic062419hSearch in Google Scholar

Hillard, E .A.; Jaouen, G. Bioorganometallics: future trends in drug discovery, analytical Chemistry and catalysis. Organometallics2011, 30, 20–27.10.1021/om100964hSearch in Google Scholar

Himeda, Y.; Onozawa-Komatsuzaki, N.; Sugihara, H.; Arakawa, H.; Kasuga, K. Half-sandwich complexes with 4,7-dihydroxy-1,10-phenanthroline: water-soluble, highly efficient catalysts for hydrogenation of bicarbonate attributable to the generation of an oxyanion on the catalyst ligand. Organometallics2004, 23, 1480–1483.10.1021/om030382sSearch in Google Scholar

Hirano, M.; Shibasaki, T.; Komiya, S.; Bennett, M. A. Synthesis of and stereospecific hydride migration in cationic (tricyclic arene)(cyclooctadiene)ruthenium(II) complexes. Organometallics2002, 21, 5738–5745.10.1021/om0205997Search in Google Scholar

Hirano, M.; Sakate, Y.; Komine, N.; Komiya, S.; Bennett, M. A. Isolation of trans-2,5-bis(methoxycarbonyl)ruthenacyclopentane by oxidative coupling of methyl acrylate on ruthenium(0) as an active intermediate for tail-to-tail selective catalytic dimerization. Organometallics2009, 28, 4902–4905.10.1021/om9004065Search in Google Scholar

Hirano, M.; Sakate, Y.; Komine, N.; Komiya, S.; Wang, X.; Bennett, M. A. Stoichiometric regio- and stereoselective oxidative coupling reactions of conjugated dienes with ruthenium(0). A mechanistic insight into the origin of selectivity. Organometallics2011, 30, 768–777.10.1021/om100956fSearch in Google Scholar

Hirano, M.; Sakate, Y.; Inoue, H.; Arai, Y.; Komine, N.; Komiya, S.; Wang, X.; Bennett, M. A. Synthesis of conjugated diene complexes of ruthenium(0) derived from Ru(η⁶-naphthalene)(η⁴-1,5-COD): Z to E isomerisation of coordinated 1,3-pentadiene. J. Organomet. Chem. 2012, 708–709, 46–57.10.1016/j.jorganchem.2012.02.018Search in Google Scholar

Hoeschele, J. D.; Habtemariam, A.; Muir, J.; Sadler, P. J. 106Ru radiolabelling of the antitumour complex [(η⁶-fluorene)Ru(en)Cl]PF₆. Dalton Trans. 2007, 4974–4979.10.1039/b706246jSearch in Google Scholar PubMed

Hofmeier, H.; Andres, P. R.; Schubert, U. S. Triads containing terpyridine-ruthenium(II) complexes and the perylene fluorescent dye. Metal-Containing and Metallo-Supramolecular Polymers and Materials, ACS Symposium Series, Chapter 7, 2006; Vol. 928, pp. 86–96.10.1021/bk-2006-0928.ch007Search in Google Scholar

Hostetter, A. A.; Miranda, M. L.; DeRose, V. J.; McFarlane Holman, K. L. Ru binding to RNA following treatment with the antimetastatic prodrug NAMI-A in Saccharomyces cerevisiae and in vitro. J. Biol. Inorg. Chem. 2011, 16, 1177–1185.10.1007/s00775-011-0806-7Search in Google Scholar PubMed PubMed Central

Hotze, A. C.; Bacac, M.; Velders, A. H.; Jansen, B. A.; Kooijman, H.; Spek, A. L.; Haasnoot, J. G.; Reedijk, J. New cytotoxic and water-soluble bis(2-phenylazopyridine)ruthenium(II) complexes. J. Med. Chem. 2003, 46, 1743–1750.10.1021/jm021110eSearch in Google Scholar PubMed

Hu, W.; Luo, Q.; Ma, X.; Wu, K.; Liu, J.; Chen, Y.; Xiong, S.; Wang, J.; Sadler, P. J.; Wang, F. Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chem. Eur. J. 2009, 15, 6586–6594.10.1002/chem.200900699Search in Google Scholar PubMed

Jain, A.; Wang, J.; Mashack, E. R.; Winkel, B. S. J.; Brewer, K. J. Multifunctional DNA interactions of Ru-Pt mixed metal supramolecular complexes with substituted terpyridine ligands. Inorg. Chem. 2009, 48, 9077–9084.10.1021/ic900190aSearch in Google Scholar PubMed

Jakupec, M. A.; Reisner, E.; Eichinger, A.; Pongratz, M.; Arion, V. B.; Galanski, M.; Hartinger, C. G.; Keppler, B. K. Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential. J. Med. Chem. 2005, 48, 2831–2837.10.1021/jm0490742Search in Google Scholar PubMed

Jerphagnon, T.; Gayet, A. J.; Berthiol, F.; Ritleng, V.; Mrsić, N.; Meetsma, A.; Pfeffer, M.; Minnaard, A. J.; Feringa, B. L.; de Vries, J. G. Fast racemisation of chiral amines and alcohols by using cationic half-sandwich ruthena- and iridacycle catalysts. Chemistry2009, 15, 12780–12790.10.1002/chem.200902103Search in Google Scholar PubMed

Jiménez-Tenorio, M.; Palacios, M. D.; Puerta, M. C.; Valerga, P. Half-sandwich hydride complexes of ruthenium with bidentate phosphinoamine ligands: proton-transfer reactions to [(C₅R₅)RuH(L)] [R=H, Me; L=dippae, (R,R)-dippach]. Inorg. Chem. 2007, 46, 1001–1012.10.1021/ic061745uSearch in Google Scholar PubMed

Jiménez-Tenorio, M.; Puerta, M. C.; Valerga, P.; Moncho, S.; Ujaque, G.; Lledós, A. Proton-transfer reactions to half-sandwich ruthenium trihydride complexes bearing hemilabile P,N ligands: experimental and density functional theory studies. Inorg. Chem. 2010, 49, 6035–6057.10.1021/ic100710dSearch in Google Scholar PubMed

Kamatchi, T. S.; Chitrapriya, N.; Lee, H.; Fronczek, C. F.; Fronczek, F. R.; Natarajan, K. Ruthenium(II)/(III) complexes of 4-hydroxy-pyridine-2;6-dicarboxylic acid with PPh₃/AsPh₃ as co-ligand: impact of oxidation state and co-ligands on anticancer activity in vitro. Dalton Trans. 2012, 41, 2066–2077.10.1039/C1DT11273BSearch in Google Scholar PubMed

Kandioller, W.; Hartinger, C. G.; Nazarov, A. A.; Bartel, C.; Skocic, M.; Jakupec, M. A.; Arion, V. B.; Keppler, B. K. Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro. Chem. Eur. J. 2009, 15, 12283–12291.10.1002/chem.200901939Search in Google Scholar PubMed

Karki, S. S.; Thota, S.; Darj, S. Y.; Balzarini, J.; De Clercq, E. Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds. Bioorg. Med. Chem. 2007, 15, 6632–6641.10.1016/j.bmc.2007.08.014Search in Google Scholar PubMed

Kilpin, K. J.; Cammack, S. M.; Clavel, C. M.; Dyson, P. J. Ruthenium(II) arene PTA (RAPTA) complexes: impact of enantiomerically pure chiral ligands. Dalton Trans. 2013, 2008–2014.10.1039/C2DT32333HSearch in Google Scholar

Koizumi, T.; Tomon, T.; Tanaka, K. Terpyridine-analogous (N,N,C)-tridentate ligands: synthesis, structures, and electrochemical properties of ruthenium(II) complexes bearing tridentate pyridinium and pyridinylidene ligands. Organometallics2003, 22, 970–975.10.1021/om020637mSearch in Google Scholar

Komiya, S.; Hurano, M. Group 8 (Fe, Ru, Os) metal compounds. In Synthesis of Organometallic Compounds: A Practical Guide. Komiya, S., Ed. John Wiley & Sons: England, 1997; pp. 159–203.Search in Google Scholar

Kopf, H.; Pietraszuk, C.; Hübner, E.; Burzlaff, N. Ruthenium carbene, vinylidene, and allenylidene complexes with a bis(3,5-dimethylpyrazol-1-yl)acetato heteroscorpionate ligand. Organometallics2006, 25, 2533–2546.10.1021/om060050ySearch in Google Scholar

Kopf, H.; Holzberger, B.; Pietraszuk, C.; Hübner, E.; Burzlaff, N. Neutral ruthenium carbene complexes bearing N,N,O heteroscorpionate ligands: syntheses and activity in metathesis reactions. Organometallics2008, 27, 5894–5905.10.1021/om8006129Search in Google Scholar

Kostrhunova, H.; Florian, J.; Novakova, O.; Peacock, A. F.; Sadler, P. J.; Brabec, V. DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. J. Med. Chem. 2008, 51, 3635–3643.10.1021/jm701538wSearch in Google Scholar PubMed

Kou, J. F.; Qian, C.; Wang, J. Q.; Chen, X.; Wang, L. L.; Chao, H.; Ji, L. N. Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases I and II. J. Biol. Inorg. Chem. 2012, 17, 81–96.10.1007/s00775-011-0831-6Search in Google Scholar PubMed

Kowol, C. R.; Reisner, E.; Chiorescu, I.; Arion, V. B.; Galanski, M.; Deubel, D. V.; Keppler, B. K. An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent α-N-heterocyclic chalcogensemicarbazones. Inorg. Chem. 2008, 47, 11032–11047.10.1021/ic8013249Search in Google Scholar PubMed

Linares, F.; Galindo, M. A.; Galli, S.; Romero, M. A.; Navarro, J. A.; Barea, E. Tetranuclear coordination assemblies based on half-sandwich ruthenium(II) complexes: noncovalent binding to DNA and cytotoxicity. Inorg. Chem. 2009, 48, 7413–7420.10.1021/ic900980ySearch in Google Scholar PubMed

Liu, H. K.; Wang, F.; Parkinson, J. A.; Bella, J.; Sadler, P. J. Ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes. Chemistry2006, 12, 6151–6165.10.1002/chem.200600110Search in Google Scholar PubMed

Liu, J.; Zheng, W.; Shi, S.; Tan, C.; Chen, J.; Zheng, K.; Ji, L. Synthesis, antitumor activity and structure-activity relationships of a series of Ru(II) complexes. J. Inorg. Biochem. 2008, 102, 193–202.10.1016/j.jinorgbio.2007.07.035Search in Google Scholar PubMed

Liu, X. W.; Chen, Z. G.; Li, L.; Chen, Y. D.; Lu, J. L.; Zhang, D. S. DNA-binding, photocleavage studies of ruthenium(II) complexes with 2-(2-quinolinyl) imidazo[4,5-f][1,10]phenanthroline. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2012, 102C, 142–149.10.1016/j.saa.2012.10.025Search in Google Scholar PubMed

Loughrey, B. T.; Healy, P. C.; Parsons, P. G.; Williams, M. L. Selective cytotoxic Ru(II) arene Cp* complex salts [R-PhRuCp*]+X- for X=BF₄-, PF₆-, and BPh₄. Inorg. Chem. 2008, 47, 8589–8591.10.1021/ic801159fSearch in Google Scholar PubMed

Loughrey, B. T.; Cunning, B. V.; Healy, P. C.; Brown, C. L.; Parsons, P. G.; Williams, M. L. Selective, cytotoxic organoruthenium(II) full-sandwich complexes: a structural, computational and in vitro biological study. Chem. Asian J. 2012, 7, 112–121.10.1002/asia.201100637Search in Google Scholar PubMed

Magennis, S. W.; Habtemariam, A.; Novakova, O.; Henry, J. B.; Meier, S.; Parsons, S.; Oswald, I. D.; Brabec, V.; Sadler, P. J. Dual triggering of DNA binding and fluorescence via photoactivation of a dinuclear ruthenium(II) arene complex. Inorg. Chem. 2007, 46, 5059–5068.10.1021/ic062111qSearch in Google Scholar PubMed

Małecki, J. G.; Kruszynski, R.; Mazurak, Z. Synthesis, spectroscopic and structural characterizations of two new complexes of ruthenium with 2-(hydroxymethyl)benzimidazole and 1,10-phenanthroline ligands. Polyhedron2009, 28, 3891–3898.10.1016/j.poly.2009.08.035Search in Google Scholar

Marchetti, F.; Pettinari, C.; Pettinari, R.; Cerquetella, A.; Di Nicola, C.; Macchioni, A.; Zuccaccia, D.; Monari, M.; Piccinelli, F. Synthesis and intramolecular and interionic structural characterization of half-sandwich (arene)ruthenium(II) derivatives of bis(pyrazolyl)alkanes. Inorg. Chem. 2008, 47, 11593–11603.10.1021/ic801150cSearch in Google Scholar PubMed

Martínez, A.; Suárez, J.; Shand, T.; Magliozzo, R. S.; Sánchez-Delgado, R. A. Interactions of arene-Ru(II)-chloroquine complexes of known antimalarial and antitumor activity with human serum albumin (HSA) and transferrin. J. Inorg. Biochem. 2011, 105, 39–45.10.1016/j.jinorgbio.2010.09.005Search in Google Scholar PubMed PubMed Central

Mazumder, U. K.; Gupta, M.; Karki, S. S.; Bhattacharya, S.; Rathinasamy, S.; Thangavel, S. Synthesis, anticancer and antibacterial activity of some novel mononuclear Ru(II) complexes. Chem. Pharm. Bull. (Tokyo) 2004, 52, 178–185.10.1248/cpb.52.178Search in Google Scholar PubMed

McNae, I. W.; Fishburne, K.; Habtemariam, A.; Hunter, T. M.; Melchart, M.; Wang, F.; Walkinshaw, M. D.; Sadler, P. J. Half-sandwich arene ruthenium(II)-enzyme complex. Chem. Commun. (Camb.) 2004, 1786–1787.10.1039/B408141BSearch in Google Scholar

Meggers, E. Exploring biologically relevant chemical space with metal complexes. Curr. Opin. Chem. Biol. 2007, 11, 287–292.10.1016/j.cbpa.2007.05.013Search in Google Scholar PubMed

Meggers, E. Targeting proteins with metal complexes. Chem. Commun. 2009, 1001–1010.10.1039/b813568aSearch in Google Scholar PubMed

Meggers, E.; Atilla-Gokcumen, G. E.; Gründler, K.; Frias, C.; Prokop, A. Inert ruthenium half-sandwich complexes with anticancer activity. Dalton Trans. 2009, 10882–10888.10.1039/b917792bSearch in Google Scholar PubMed

Melchart, M.; Sadler, P. J. Ruthenium arene anticancer complexes. In Bioorganometallics. Jaouen, G., Ed. Wiley-VCH Verlag GmbH 6 Co. KGAA: Weinheim, 2006; pp. 39–62.10.1002/3527607692.ch2Search in Google Scholar

Melchart, M.; Habtemariam, A.; Parsons, S.; Sadler, P. J. Chlorido-, aqua-, 9-ethylguanine- and 9-ethyladenine-adducts of cytotoxic ruthenium arene complexes containing O,O-chelating ligands. J. Inorg. Biochem. 2007, 101, 1903–1912.10.1016/j.jinorgbio.2007.04.018Search in Google Scholar PubMed

Mendoza-Ferri, M. G.; Hartinger, C. G.; Mendoza, M. A.; Groessl, M.; Egger, A. E.; Eichinger, R. E.; Mangrum, J. B.; Farrell, N. P.; Maruszak, M.; Bednarski, P. J.; Klein, F.; Jakupec, M. A.; Nazarov, A. A.; Severin, K.; Keppler, B. K. Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity. J. Med. Chem. 2009, 52, 916–925.10.1021/jm8013234Search in Google Scholar PubMed PubMed Central

Micallef, L. S.; Loughrey, B. T.; Healy, P. C.; Parsons, P. G.; Williams, M. L. Mono- and 1,10-disubstituted organoruthenium cyclopentadiene complexes: synthesis, structural characterization, and antitumoral evaluation. Organometallics2011, 30, 1395–1403.10.1021/om100928sSearch in Google Scholar

Mitra, R.; Das, S.; Shinde, S. V.; Sinha, S.; Somasundaram K.; Samuelson, A. G. Anticancer activity of hydrogen-bond-stabilized half-sandwich Ru(II) complexes with heterocycles. Chem. Eur. J. 2012, 18, 12278–12291.10.1002/chem.201200938Search in Google Scholar PubMed

Mitsopoulou, C. A.; Veroni, I.; Philippopoulos, A. I.; Falaras, P. Synthesis, characterization and sensitization properties of two novel mono and bis carboxyl-dipyrido-phenazine ruthenium(II) charge transfer complexes. J. Photochem. Photobio. A Chem. 2007, 191, 6–12.10.1016/j.jphotochem.2007.03.024Search in Google Scholar

Morais, T. S.; Santos, F. C.; Jorge, T. F.; Corte-Real, L.; Madeira, P. J. A.; Marques, F.; Robalo, M. P.; Matos, A.; Santos, I.; Garcia, M. H. New water-soluble ruthenium(II) cytotoxic complex: biological activity and cellular distribution. J. Inorg. Biochem. 2014, 130, 1–14.10.1016/j.jinorgbio.2013.09.013Search in Google Scholar PubMed

Morris, R. E.; Aird, R. E.; Murdoch Pdel, S.; Chen, H.; Cummings, J.; Hughes, N. D.; Parsons, S.; Parkin, A.; Boyd, G.; Jodrell, D. I.; Sadler, P. J. Inhibition of cancer cell growth by ruthenium(II) arene complexes. J. Med. Chem. 2001, 44, 3616–3621.10.1021/jm010051mSearch in Google Scholar PubMed

Mura, P.; Camalli, M.; Messori, L.; Piccioli, F.; Zanello, P.; Corsini, M. Synthesis, structural characterization, solution Chemistry and preliminary biological studies of the ruthenium(III) complexes [TzH][trans-RuCl₄(Tz)₂] and [TzH][trans-RuCl₄(DMSO)(Tz)].(DMSO), the thiazole analogues of antitumor ICR and NAMI-A. Inorg. Chem. 2004, 43, 3863–3670.10.1021/ic0354116Search in Google Scholar PubMed

Nakabayashi, Y.; Watanabe, Y.; Nakao, T.; Yamauchi, O. Interactions of mixed ligand ruthenium(II) complexes containing an amino acid and 1,10-phenanthroline with DNA. Inorg. Chim. Acta2004, 357, 2553–2560.10.1016/j.ica.2004.02.020Search in Google Scholar

Nazarov, A. A.; Risse, J.; Ang, W. H.; Schmitt, F.; Zava, O.; Ruggi, A.; Groessl, M.; Scopelitti, R.; Juillerat-Jeanneret, L.; Hartinger, C. G.; Dyson, P. J. Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds. Inorg. Chem. 2012, 51, 3633–3639.10.1021/ic202530jSearch in Google Scholar PubMed

Niyazi, H.; Hall, J. P.; O’Sullivan, K.; Winter, G.; Sorensen, T.; Kelly, J. M.; Cardin, C. J. Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes. Nat. Chem. 2012, 4, 621–628.10.1038/nchem.1397Search in Google Scholar PubMed

Novakova, O.; Chen, H.; Vrana, O.; Rodger, A.; Sadler, P. J.; Brabec, V. DNA interactions of monofunctional organometallic ruthenium(II) antitumor complexes in cell-free media. Biochemistry2003, 42, 11544–11554.10.1021/bi034933uSearch in Google Scholar PubMed

Novakova, O.; Kasparkova, J.; Bursova, V.; Hofr, C.; Vojtiskova, M.; Chen, H.; Sadler, P. J.; Brabec, V. Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA binding proteins and repair. Relationship to cytotoxicity. Chem. Biol. 2005, 12, 121–129.10.1016/j.chembiol.2004.11.008Search in Google Scholar PubMed

Novakova, O.; Malina, J.; Suchankova, T.; Kasparkova, J.; Bugarcic, T.; Sadler, P. J.; Brabec, V. Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru(II) complexes containing terphenyl arenes. Chemistry2010, 16, 5744–5754.10.1002/chem.200903078Search in Google Scholar PubMed

Nowak-Sliwinska, P.; van Beijnum, J. R.; Casini, A.; Nazarov, A. A.; Wagnieres, G.; van den Bergh, H.; Dyson, P. J.; Griffioen, A. W. Organometallic ruthenium(II) arene compounds with antiangiogenic activity. J. Med. Chem. 2011, 54, 3895–3902.10.1021/jm2002074Search in Google Scholar PubMed

Ohki, Y.; Sadohara, H.; Takikawa, Y.; Tatsumi, K. A half-sandwich ruthenium(II) complex containing a coordinatively unsaturated 2,6-dimesitylphenyl thiolate ligand. Angew Chem. Int. Ed. Engl. 2004, 43, 2290–2293.10.1002/anie.200353611Search in Google Scholar PubMed

Pagano, N.; Maksimoska, J.; Bregman, H.; Williams, D. S.; Webster, R. D.; Xue, F.; Meggers, E. Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand. Org. Biomol. Chem. 2007, 5, 1218–1227.10.1039/b700433hSearch in Google Scholar PubMed

Page, S. Ruthenium compounds as anticancer agents. Educ. Chem. 2012, 26–29. Available at: http://www.rsc.org/eic.Search in Google Scholar

Pascu, G. I.; Hotze, A. C.; Sanchez-Cano, C.; Kariuki, B. M.; Hannon, M. J. Dinuclear ruthenium(II) triple-stranded helicates: luminescent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines. Angew Chem. Int. Ed. Engl. 2007, 46, 4374–4378.10.1002/anie.200700656Search in Google Scholar PubMed

Peacock, A. F.; Sadler, P. J. Medicinal organometallic chemistry: designing metal arene complexes as anticancer agents. Chem. Asian J. 2008, 3, 1890–1899.10.1002/asia.200800149Search in Google Scholar PubMed

Peacock, A. F.; Habtemariam, A.; Fernández, R.; Walland, V.; Fabbiani, F. P.; Parsons, S.; Aird, R. E.; Jodrell, D. I.; Sadler, P. J. Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions. J. Am. Chem. Soc. 2006, 128, 1739–1748.10.1021/ja055886rSearch in Google Scholar PubMed

Peacock, A. F.; Habtemariam, A.; Moggach, S. A.; Prescimone, A.; Parsons, S.; Sadler, P. J. Chloro half-sandwich osmium(II) complexes: influence of chelated N,N-ligands on hydrolysis, guanine binding, and cytotoxicity. Inorg. Chem. 2007a, 46, 4049–4059.10.1021/ic062350dSearch in Google Scholar PubMed

Peacock, A. F.; Parsons, S.; Sadler, P. J. Tuning the hydrolytic aqueous chemistry of osmium arene complexes with N,O-chelating ligands to achieve cancer cell cytotoxicity. J. Am. Chem. Soc. 2007b, 129, 3348–3357.10.1021/ja068335pSearch in Google Scholar

Pelletier, F.; Comte, V.; Massard, A.; Wenzel, M.; Toulot, S.; Richard, P.; Picquet, M.; Le Gendre, P.; Zava, O.; Edafe, F.; Casini, A.; Dyson, P. J. Development of bimetallic titanocene-ruthenium-arene complexes as anticancer agents: relationships between structural and biological properties. J. Med. Chem. 2010, 53, 6923–6933.10.1021/jm1004804Search in Google Scholar

Pertici, P.; Verrazzani, A.; Vitulli, G.; Baldwin, R.; Bennett, M. A. Stoichiometric alkyne cyclotrimerization at a ruthenium centre: a new synthetic route to Ru(η⁶-arene)(η⁴-cycloocta-1,5-diene) complexes. J. Organomet. Chem. 1998, 551, 37–47.10.1016/S0022-328X(97)00425-7Search in Google Scholar

Pitto-Barry, A.; Barry, N. P.; Zava, O.; Deschenaux, R.; Dyson, P. J.; Therrien, B. Double targeting of tumours with pyrenyl-modified dendrimers encapsulated in an arene-ruthenium metallaprism. Chemistry2011, 17, 1966–1971.10.1002/chem.201002634Search in Google Scholar

Pitto-Barry, A.; Zava, O.; Dyson, P. J.; Deschenaux, R.; Therrien, B. Enhancement of cytotoxicity by combining pyrenyl-dendrimers and arene ruthenium metallacages. Inorg. Chem. 2012, 51, 7119–7124.10.1021/ic202739dSearch in Google Scholar

Procopio, E. Q.; Rojas, S.; Padial, N. M.; Galli, S.; Masciocchi, N.; Linares, F.; Miguel, D.; Oltra, J. E.; Navarro, J. A.; Barea, E. Study of the incorporation and release of the non-conventional half-sandwich ruthenium(II) metallodrug RAPTA-C on a robust MOF. Chem. Commun. (Camb.) 2011, 47, 11751–11753.10.1039/c1cc14594kSearch in Google Scholar

Pruchnik, F. P.; Gałdecka, E.; Gałdecki, Z.; Kowalski, A. Carbonyl ruthenium(III) complexes with 1,10-phenanthroline and 2,2′-bipyridine. Polyhedron1999, 18, 2091–2097.10.1016/S0277-5387(99)00079-0Search in Google Scholar

Rajalakshmanan, E.; Alexander, V. Synthesis, luminescence, and electrochemical studies of tris(homoleptic) ruthenium(II) and osmium(II) complexes of 6′-tolyl-2,2′:4′,2″-terpyridine. Inorg. Chem. 2007, 46, 6252–6260.10.1021/ic0700093Search in Google Scholar PubMed

Rajapakse, C. S. K.; Martinez, A.; Naoulou, B.; Jarzecki, A. A.; Suarez, L.; Deregnaucourt, C.; Sinou, V.; Schrével, J.; Musi, E.; Ambrosini, G.; Schwartz, G. K.; Sanchez-Delgado, R. A. Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine. Inorg. Chem. 2009, 48, 1122–1131.10.1021/ic802220wSearch in Google Scholar PubMed PubMed Central

Rajendiran, V.; Murali, M.; Suresh, E.; Palaniandavar, M.; Periasamy, V. S.; Akbarsha, M. A. Non-covalent DNA binding and cytotoxicity of certain mixed-ligand ruthenium(II) complexes of 2,2′-dipyridylamine and diimines. Dalton Trans. 2008, 2157–2170.10.1039/b715077fSearch in Google Scholar PubMed

Ratanaphan, A.; Temboot, P.; Dyson, P. J. In vitro ruthenation of human breast cancer suppressor gene 1 (BRCA1) by the antimetastasis compound RAPTA-C and its analogue carboRAPTA-C. Chem. Biodivers. 2010, 7, 1290–1302.10.1002/cbdv.200900288Search in Google Scholar

Renfrew, A. K.; Scopelliti, R.; Dyson, P. J. Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting. Inorg. Chem. 2010, 49, 2239–2246.10.1021/ic9020433Search in Google Scholar

Ritleng, V.; Bertani, P.; Pfeffer, M.; Sirlin, C.; Hirschinger, J. Optically active ortho-metalated half-sandwich ruthenium complexes: solid-state NMR as a convenient tool to analyze mixtures of diastereomers. Inorg. Chem. 2001, 40, 5117–5122.10.1021/ic010204wSearch in Google Scholar

Romerosa, A.; Campos-Malpartida, T.; Lidrissi, C.; Saoud, M.; Serrano-Ruiz, M.; Peruzzini, M.; Garrido-Cárdenas, J. A.; García-Maroto, F. Synthesis, characterization, and DNA binding of new water-soluble cyclopentadienyl ruthenium(II) complexes incorporating phosphines. Inorg. Chem. 2006, 45, 1289–1298.10.1021/ic051053qSearch in Google Scholar

Ruiz, J.; Vicente, C.; de Haro, C.; Bautista, D. A novel ruthenium(II) arene based intercalator with potent anticancer activity. Dalton Trans. 2009, 5071–5073.10.1039/b907296aSearch in Google Scholar

Sanchez-Delgado, R. A.; Navarro, M.; Perez, H.; Urbina, J. A. Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium- and rhodium-chloroquine complexes. J. Med. Chem. 1996, 39, 1095–1099.10.1021/jm950729wSearch in Google Scholar

Sava, G.; Bergamoa, A.; Dyson P. J. Metal-based antitumour drugs in the post-genomic era: what comes next?. Dalton Trans. 2011, 40, 9069–9075.10.1039/c1dt10522aSearch in Google Scholar

Schluter, A.; Bieber, K.; Sheldrick, W. S. Preparation, structure and coordination properties of (h-p-cymene)ruthenium(II) sandwich complexes of catechol and 5-hydroxyindole derivatives. Inorg. Chim. Acta2002, 340, 35–43.10.1016/S0020-1693(02)01074-5Search in Google Scholar

Schmid, W. F.; John, R. O.; Mühlgassner, G.; Heffeter, P.; Jakupec, M. A.; Galanski, M.; Berger, W.; Arion, V. B.; Keppler, B. K. Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy. J. Med. Chem. 2007, 50, 6343–6355.10.1021/jm701042wSearch in Google Scholar PubMed

Schmitt, F.; Govindaswamy, P.; Süss-Fink, G.; Ang, W. H.; Dyson, P. J.; Juillerat-Jeanneret, L.; Therrien, B. Ruthenium porphyrin compounds for photodynamic therapy of cancer. J. Med. Chem. 2008, 51, 1811–1816.10.1021/jm701382pSearch in Google Scholar PubMed

Schmitt, F.; Govindaswamy, P.; Zava, O.; Süss-Fink, G.; Juillerat-Jeanneret, L.; Therrien, B. Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy. J. Biol. Inorg. Chem. 2009, 14, 101–109.10.1007/s00775-008-0427-ySearch in Google Scholar PubMed

Scolaro, C.; Bergamo, A.; Brescacin, L.; Delfino, R.; Cocchietto, M.; Laurenczy, G.; Geldbach, T. J.; Sava, G.; Dyson, P. J. In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes. J. Med. Chem. 2005, 48, 4161–4171.10.1021/jm050015dSearch in Google Scholar PubMed

Scolaro, C.; Chaplin, A. B.; Hartinger, C. G.; Bergamo, A.; Cocchietto, M.; Keppler, B. K.; Sava, G.; Dyson, P. J. Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake; biomolecular interactions and efficacy. Dalton Trans. 2007, 5065–5072.10.1039/b705449aSearch in Google Scholar PubMed

Scolaro, C.; Hartinger, C. G.; Allardyce, C. S.; Keppler, B. K.; Dyson, P. J. Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η⁶-p-cymene)Cl₂(PTA)]. J. Inorg. Biochem. 2008, 102, 1743–1748.10.1016/j.jinorgbio.2008.05.004Search in Google Scholar PubMed

Sharma, S.; Singh, S. K.; Chandra, M.; Pandey, D. S. DNA-binding behavior of ruthenium(II) complexes containing both group 15 donors and 2,2′:6′,2″-terpyridine. J. Inorg. Biochem. 2005, 99, 458–466.10.1016/j.jinorgbio.2004.10.021Search in Google Scholar PubMed

Shin, R. Y. C.; Bennett, M. A.; Goh, L. Y.; Chen, W.; Hockless, D. C. R.; Leong, W. K.; Mashima, K.; Willis A. C. Arene-ruthenium complexes of an acyclic thiolate-thioether and tridentate thioether derivatives resulting from ring-closure reactions. Inorg. Chem. 2003, 42, 96–106.10.1021/ic0203419Search in Google Scholar PubMed

Singh, S. K.; Joshi, S.; Singh, A. R.; Saxena, J. K.; Pandey, D. S. DNA binding and topoisomerase II inhibitory activity of water-soluble ruthenium(II) and rhodium(III) complexes. Inorg. Chem. 2007, 46, 10869–10876.10.1021/ic700885mSearch in Google Scholar PubMed

Stepanenko, I. N.; Casini, A.; Edafe, F.; Novak, M. S.; Arion, V. B.; Dyson, P. J.; Jakupec, M. A.; Keppler, B. K. Conjugation of organoruthenium(II) 3-(¹H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells. Inorg. Chem. 2011, 50, 12669–12679.10.1021/ic201801eSearch in Google Scholar PubMed PubMed Central

Streu, C.; Carroll, P. J.; Kohli, R. K.; Meggers, E. Synthesis of cyclopentadienyl ruthenium complexes bearing pendant chelating picolinates through an electrophilic precursor. J. Organomet. Chem. 2008, 693, 551–556.10.1016/j.jorganchem.2007.11.024Search in Google Scholar PubMed PubMed Central

Sun, R. W.; Ng, M. F.; Wong, E. L.; Zhang, J.; Chui, S. S.; Shek, L.; Lau, T. C.; Che, C. M. Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands. Dalton Trans. 2009, 10712–10716.10.1039/b912236bSearch in Google Scholar PubMed

Süss-Fink, G. Arene ruthenium complexes as anticancer agents. Dalton Trans. 2010, 39, 1673–1688.10.1039/B916860PSearch in Google Scholar PubMed

Suss-Fink, G. Water-soluble arene ruthenium complexes: from serendipity to catalysis and drug design. J. Organomet. Chem. 2014, 751, 2–19.10.1016/j.jorganchem.2013.07.039Search in Google Scholar

Suss-Fink, G.; Khan, F.-A.; Juillerat-Jeanneret, L.; Dyson, P. J.; Renfrew, A. K. Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and nanoparticles. J. Clust. Sci. 2010, 21, 313–324.10.1007/s10876-010-0298-6Search in Google Scholar

Tampier, S.; Müller, R.; Andrea Thorn, A.; Hübner, E.; Burzlaff, N. Synthesis, structure, and reactivity of ruthenium carboxylato and 2-oxocarboxylato complexes bearing the bis(3,5-dimethylpyrazol-1-yl)acetato ligand. Inorg. Chem. 2008, 47, 9624–9641.10.1021/ic8000224Search in Google Scholar PubMed

Tan, C.; Liu, J.; Chen, L.; Shi, S.; Ji, L. Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes. J. Inorg. Biochem. 2008, 102, 1644–1653.10.1016/j.jinorgbio.2008.03.005Search in Google Scholar PubMed

Therrien, B.; Ang, W. H.; Cherioux, F.; Vieille-Petit, L.; Juillerat-Jeanneret, L.; Suss-Fink, G.; Dyson, P. J. Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters. J. Clust. Sci. 2007, 18, 741–752.10.1007/s10876-007-0140-ySearch in Google Scholar

Tomaz, A. I.; Jakusch, T.; Morais, T. S.; Marques, F.; de Almeida, R. F.; Mendes, F.; Enyedy, E. A.; Santos, I.; Pessoa, J. C.; Kiss, T.; Garcia, M. H. [Ru(II)(η)5(-C)5(H)5(((bipy)(PPh)3))])(+), a promising large spectrum antitumor agent: cytotoxic activity and interaction with human serum albumin. J. Inorg. Biochem. 2012, 117, 261–269.10.1016/j.jinorgbio.2012.06.016Search in Google Scholar PubMed

Türkoglu, G.; Tampier, S.; Strinitz, F.; Heinemann, F. W.; Hübner, E.; Burzlaff, N. Ruthenium carbonyl complexes bearing bis(pyrazol-1-yl)carboxylato ligands. Organometallics2012, 31, 2166–2174.10.1021/om2009155Search in Google Scholar

Vajpayee, V.; Yang, Y. J.; Kang, S. C.; Kim, H.; Kim, I. S.; Wang, M.; Stang, P. J.; Chi, K. W. Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents. Chem. Commun. (Camb.) 2011, 47, 5184–5186.10.1039/c1cc10167fSearch in Google Scholar PubMed PubMed Central

van Rijt, S. H.; Hebden, A. J.; Amaresekera, T.; Deeth, R. J.; Clarkson, G. J.; Parsons, S.; McGowan, P. C.; Sadler, P. J. Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes. J. Med. Chem. 2009a, 52, 7753–7764.10.1021/jm900731jSearch in Google Scholar PubMed

van Rijt, S. H.; Peacock, A. F.; Johnstone, R. D.; Parsons, S.; Sadler, P. J. Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorg. Chem. 2009b, 48, 1753–1762.10.1021/ic8020222Search in Google Scholar

Vargiu, A. V.; Robertazzi, A.; Magistrato, A.; Ruggerone, P.; Carloni, P. The hydrolysis mechanism of the anticancer ruthenium drugs NAMI-A and ICR investigated by DFT-PCM calculations. J. Phys. Chem. B2008, 112, 4401–4409.10.1021/jp710078ySearch in Google Scholar

Velders, A. H.; Bergamo, A.; Alessio, E.; Zangrando, E.; Haasnoot, J. G.; Casarsa, C.; Cocchietto, M.; Zorzet, S.; Sava, G. Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl₄(dmso-S)(dmtp)], (Na)[trans-RuCl₄(dmso-S)(dmtp)], and [mer-RuCl₃(H₂O)(dmso-S)(dmtp)] (dmtp=5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine). J. Med. Chem. 2004, 47, 1110–1121.10.1021/jm030984dSearch in Google Scholar

Vock, C. A.; Scolaro, C.; Phillips, A. D.; Scopelliti, R.; Sava, G.; Dyson, P. J. Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) η⁶-arene imidazole complexes. J. Med. Chem. 2006, 49, 5552–5561.10.1021/jm060495oSearch in Google Scholar

Vock, C. A.; Ang, W. H.; Scolaro, C.; Phillips, A. D.; Lagopoulos, L.; Juillerat-Jeanneret, L.; Sava, G.; Scopelliti, R.; Dyson, P. J. Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms. J. Med. Chem. 2007, 50, 2166–2175.10.1021/jm070039fSearch in Google Scholar

Vrábel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S. A.; Ernsting, N. P.; Hocek, M. Synthesis and photophysical properties of 7-deaza-2′-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7. Org. Biomol. Chem. 2008, 6, 2852–2860.10.1039/b805632cSearch in Google Scholar

Waern, J. B.; Dillon, C. T.; Harding, M. M. Organometallic anticancer agents: cellular uptake and cytotoxicity studies on thiol derivatives of the antitumor agent molybdocene dichloride. J. Med. Chem. 2005, 48, 2093–2099.10.1021/jm049585oSearch in Google Scholar

Walsh, J. L.; McCrackin, R.; McPhail, A. T. Preparation and X-ray crystal structure study of a polypyridyl ruthenium(II) complex containing a dehydrodithizone ligand. Polyhedron1998, 17, 3221–3226.10.1016/S0277-5387(98)00095-3Search in Google Scholar

Wang, Q.; Yu, L. Conjugated polymers containing mixed-ligand ruthenium(II) complexes. Synthesis, characterization, and investigation of photoconductive properties. J. Am. Chem. Soc. 2000, 122, 11806–11811.10.1021/ja003140hSearch in Google Scholar

Wang, F.; Chen, H.; Parsons, S.; Oswald, I. D.; Davidson, J. E.; Sadler, P. J. Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chemistry2003, 9, 5810–5820.10.1002/chem.200304724Search in Google Scholar PubMed

Wang, F.; Habtemariam, A.; van der Geer, E. P. L.; Fernandez, R.; Melchart, M.; Deeth, R. J.; Aird, R.; Guichard, S.; Fabbiani, F. P. A.; Lozano-Casal, P.; Oswald, I. D. H.; Jodrell, D. I.; Parsons, S.; Sadler, P. J. Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity. Proc. Natl. Acad. Sci. 2005a, 102, 18269–18274.10.1073/pnas.0505798102Search in Google Scholar PubMed PubMed Central

Wang, F.; Xu, J.; Habtemariam, A.; Bella, J.; Sadler, P. J. Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. J. Am Chem. Soc. 2005b, 127, 17734–17743.10.1021/ja053387kSearch in Google Scholar PubMed

Wang, X.; Liu, S.; Weng, L. H.; Jin, G. X. Preparation and structure of mono- and binuclear half-sandwich iridium, ruthenium, and rhodium carbene complexes containing 1,2-dichalcogenolao 1,2-dicarba-closo-dodecaboranes. Chemistry2007, 13, 188–195.10.1002/chem.200600854Search in Google Scholar PubMed

Wang, F.; Habtemariam, A.; van der Geer, E. P.; Deeth, R. J.; Gould, R.; Parsons, S.; Sadler, P. J. Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. J. Biol. Inorg. Chem. 2009, 14, 1065–1076.10.1007/s00775-009-0549-xSearch in Google Scholar PubMed

Wang, Y.-C.; Qian, C.; Peng, Z.-L.; Hou, X.-J.; Wang, L.-L.; Chao, H.; Ji, L.-N. Dual topoisomerase I and II poisoning by chiral Ru(II) complexes containing 2-thiophenylimidazo[4,5-f][1,10]phenanthroline derivatives. J. Inorg. Biochem. 2014a, 130, 15–27.10.1016/j.jinorgbio.2013.09.015Search in Google Scholar PubMed

Wang, Z.; Qian, H.; Yiu, S.; Sun, J.; Zhu, G. Multi-targeted organometallic ruthenium(II)-arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: a strategy to improve cytotoxicity. J. Inorg. Biochem. 2014b, 131, 47–55.10.1016/j.jinorgbio.2013.10.017Search in Google Scholar PubMed

Wei, H.; Yin, J.; Wang, E. Bis(2,2′-bipyridine)(5,6-epoxy-5,6-dihydro-[1,10] phenanthroline)ruthenium: synthesis and electrochemical and electrochemiluminescence characterization. Anal. Chem. 2008, 80, 5635–5639.10.1021/ac8001462Search in Google Scholar PubMed

Widegren, J. A.; Bennett, M. A.; Finke, R. G. Is it homogeneous or heterogeneous catalysis? Identification of bulk ruthenium metal as the true catalyst in benzene hydrogenations starting with the monometallic precursor, Ru(II)(η⁶-C₆Me₆)(OAc)₂, plus kinetic characterization of the heterogeneous nucleation, then autocatalytic surface-growth mechanism of metal film formation. J. Am. Chem. Soc. 2003, 125, 10301–10310.10.1021/ja021436cSearch in Google Scholar PubMed

Williams, J. P.; Lough, J. A.; Campuzano, I.; Richardson, K.; Sadler, P. J. Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide. Rapid Commun. Mass Spectrom. 2009, 23, 3563–3569.10.1002/rcm.4285Search in Google Scholar PubMed

Wu, A.; Kennedy, D. C.; Patrick, B. O.; James, B. R. Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: synthesis and MTT assay. Inorg. Chem. 2003, 42, 7579–7586.10.1021/ic030119jSearch in Google Scholar PubMed

Wu, D. H.; Wu, C. H.; Li, Y. Z.; Guo, D. D.; Wang, X. M.; Yan, H. Addition of ethynylferrocene to transition-metal complexes containing a chelating 1,2-dicarba-closo-dodecaborane-1,2-dichalcogenolate ligand – in vitro cooperativity of a ruthenium compound on cellular uptake of an anticancer drug. Dalton Trans. 2009, 285–290.10.1039/B810831ESearch in Google Scholar

Wu, K.; Luo, Q.; Hu, W.; Li, X.; Wang, F.; Xiong, S.; Sadler, P. J. Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics2012, 4, 139–148.10.1039/c2mt00162dSearch in Google Scholar PubMed

Xu, L.; Zhong, N. J.; Huang, H. L.; Liang, Z. H.; Li, Z. Z.; Liu, Y. J. Synthesis, characterization, cellular uptake, apoptosis, cytotoxicity, DNA-binding, and antioxidant activity studies of ruthenium(II) complexes. Nucleosides Nucleotides Nucleic Acids2012, 31, 575–591.10.1080/15257770.2012.704110Search in Google Scholar PubMed

Yamanari, K.; Ito, R.; Yamamoto, S.; Konno, T.; Fuyuhiro, A.; Fujioka, K.; Arakawa, R. Cyclic tetramers composed of rhodium(III), iridium(III), or ruthenium(II) half-sandwich and 6-purinethiones. Inorg. Chem. 2002, 41, 6824–6830.10.1021/ic020449oSearch in Google Scholar PubMed

Yan, Y. K.; Melchart, M.; Habtemariam, A.; Sadler, P. J. Organometallic chemistry biology and medicine: ruthenium arene anticancer complexes. Chem. Commun. (Camb.) 2005, 4764–4776.10.1039/b508531bSearch in Google Scholar PubMed

Yan, Y. K.; Melchart, M.; Habtemariam, A.; Peacock, A. F.; Sadler, P. J. Catalysis of regioselective reduction of NAD⁺ by ruthenium(II) arene complexes under biologically relevant conditions. J. Biol. Inorg. Chem. 2006, 11, 483–488.10.1007/s00775-006-0098-5Search in Google Scholar PubMed

Yasuda, H.; Lee, V. Y.; Sekiguchi, A. η(5)-1,2,3-trisilacyclopentadienyl – a ligand for transition metal complexes: rhodium half-sandwich and ruthenium sandwich. J. Am. Chem. Soc. 2009, 131, 9902–9903.10.1021/ja9038664Search in Google Scholar PubMed

Yu, H. J.; Chen, Y.; Yu, L.; Hao, Z. F.; Zhou, L. H. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)₂(mitatp)]²⁺. Eur. J. Med. Chem. 2012, 55, 146–154.10.1016/j.ejmech.2012.07.014Search in Google Scholar PubMed

Zhang, W. Z.; Han, Y. F.; Lin, Y. J.; Jin, G. X. Synthesis and characterization of molecular rectangles of half-sandwich p-cymene ruthenium complexes bearing oxamidato ligands. Dalton Trans. 2009, 8426–8431.10.1039/b909357eSearch in Google Scholar PubMed

Zhao, G.; Lin, H. Metal complexes with aromatic N-containing ligands as potential agents in cancer treatment. Curr. Med. Chem. Anticancer Agents2005, 5, 137–147.10.2174/1568011053174873Search in Google Scholar PubMed

Zhao, M.; Yu, Z.; Yan, S.; Li, Y. Ruthenium(II) complex catalysts bearing a pyridyl-supported pyrazolyl-imine ligand for transfer hydrogenation of ketones. J. Organomet. Chem. 2009, 694, 3068–3075.10.1016/j.jorganchem.2009.05.028Search in Google Scholar

Zhou, G.; Harruna, I. I. Synthesis and characterization of bis(2,2′:6′,2″-terpyridine)ruthenium(II)-connected diblock polymers via RAFT polymerization. Macromolecules2005, 38, 4114–4123.10.1021/ma047955cSearch in Google Scholar

Zhou, Q.; Lei, W.; Chen, Y.; Li, C.; Hou, Y.; Zhang, B.; Wang, X. Ruthenium(II)-arene complexes with strong fluorescence: insight into the underlying mechanism. Chemistry2012, 18, 8617–8621.10.1002/chem.201200960Search in Google Scholar PubMed

Zhu, X. J.; Holliday, B. J. Electropolymerization of a ruthenium(II) bis(pyrazolyl)pyridine complex to form a novel Ru-containing conducting metallopolymer. Macromol. Rapid Commun. 2010, 31, 904–909.10.1002/marc.200900902Search in Google Scholar PubMed

Zuccaccia, D.; Bellachioma, G.; Cardaci, G.; Zuccaccia, C.; Macchioni, A. Aggregation tendency and reactivity toward AgX of cationic half-sandwich ruthenium(II) complexes bearing neutral N,O-ligands. Dalton Trans. 2006, 1963–1971.10.1039/b514269eSearch in Google Scholar PubMed