Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter October 30, 2021

Risk factors for heat-related illnesses during the Hajj mass gathering: an expert review

  • Saber Yezli ORCID logo EMAIL logo

Abstract

Human exposure to a hot environment may result in various heat-related illnesses (HRIs), which range in severity from mild and moderate forms to life-threatening heatstroke. The Hajj is one of the largest annual mass gatherings globally and has historically been associated with HRIs. Hajj attracts over two million Muslim pilgrims from more than 180 countries to the holy city of Makkah, Kingdom of Saudi Arabia. Several modifiable and non-modifiable factors render Hajj pilgrims at increased risk of developing HRIs during Hajj. These include characteristics of the Hajj, its location, population, and rituals, as well as pilgrims’ knowledge of HRIs and their attitude and behavior. Makkah is characterized by a hot desert climate and fluctuating levels of relative humidity. Pilgrims are very diverse ethnically and geographically, with different adaptations to heat. Significant proportions of the Hajj population are elderly, obese, and with low levels of fitness. In addition, many have underlying health conditions and are on multiple medications that can interfere with thermoregulation. Other factors are inherent in the Hajj and its activities, including crowding, physically demanding outdoor rituals, and a high frequency of infection and febrile illness. Pilgrims generally lack awareness of HRIs, and their uptake of preventive measures is variable. In addition, many engage in hazardous behaviors that increase their risk of HRIs. These include performing rituals during the peak sunshine hours with no sun protection and with suboptimal sleep, nutrition, and hydration, while neglecting treatment for their chronic conditions. HRIs preventive plans for Hajj should incorporate measures to address the aforementioned factors to reduce the burden of these illnesses in future Hajj seasons. Lessons from the Hajj can be used to inform policy making and HRIs preventive measures in the general population worldwide.


Corresponding author: Dr Saber Yezli, The Global Centre for Mass Gatherings Medicine, Public Health Directorate, Ministry of Health, Riyadh, Saudi Arabia, Phone: +966 11401555 ext 1863, E-mail:

  1. Research funding: None to declare.

  2. Author contribution: The author accepts responsibility for the entire content of this manuscript and approves its submission.

  3. Competing interests: Author states no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

References

1. Wexler, RK. Evaluation and treatment of heat-related illnesses. Am Fam Physician 2002;65:2307–14.Search in Google Scholar

2. Gauer, R, Meyers, BK. Heat-related illnesses. Am Fam Physician 2019;99:482–9.Search in Google Scholar

3. Krau, SD. Heat-related illness: a hot topic in critical care. Crit Care Nurs Clin 2013;25:251–62. https://doi.org/10.1016/j.ccell.2013.02.012.Search in Google Scholar PubMed

4. Leon, LR, Bouchama, A. Heat stroke. Comp Physiol 2015;5:611–47. https://doi.org/10.1002/cphy.c140017.Search in Google Scholar PubMed

5. Bouchama, A, Knochel, JP. Heat stroke. N Engl J Med 2002;346:1978–88. https://doi.org/10.1056/nejmra011089.Search in Google Scholar PubMed

6. Glazer, JL. Management of heatstroke and heat exhaustion. Am Fam Physician 2005;71:2133–40.Search in Google Scholar

7. Becker, JA, Stewart, LK. Heat-related illness. Am Fam Physician 2011;83:1325–30.Search in Google Scholar

8. Kovats, RS, Hajat, S. Heat stress and public health: a critical review. Annu Rev Publ Health 2008;29:41–55. https://doi.org/10.1146/annurev.publhealth.29.020907.090843.Search in Google Scholar PubMed

9. Khogali, M. Epidemiology of heat illnesses during the Makkah pilgrimages in Saudi Arabia. Int J Epidemiol 1983;12:267–73. https://doi.org/10.1093/ije/12.3.267.Search in Google Scholar PubMed

10. Williams, ML. Global warming, heat-related illnesses, and the dermatologist. Int J Womens Dermatol 2021;7:70–84. https://doi.org/10.1016/j.ijwd.2020.08.007.Search in Google Scholar PubMed PubMed Central

11. Martiello, MA, Giacchi, MV. High temperatures and health outcomes: a review of the literature. Scand J Publ Health 2010;38:826–37. https://doi.org/10.1177/1403494810377685.Search in Google Scholar PubMed

12. Gasparrini, A, Guo, Y, Hashizume, M, Lavigne, E, Zanobetti, A, Schwartz, J, et al.. Mortality risk attributable to high and low ambient temperature: a multicountry observational study. Lancet 2015;386:369–75. https://doi.org/10.1016/s0140-6736(14)62114-0.Search in Google Scholar PubMed PubMed Central

13. United Nations Office for Disaster Risk Reduction (UNISDR). The human cost of weather-related disasters: 1995–2015. Geneva: UNISDR; 2016.Search in Google Scholar

14. Robine, JM, Cheung, SL, Le Roy, S, Van Oyen, H, Griffiths, C, Michel, JP, et al.. Death toll exceeded 70,000 in Europe during the summer of 2003. C R Biol 2008;331:171–8. https://doi.org/10.1016/j.crvi.2007.12.001.Search in Google Scholar PubMed

15. Barriopedro, D, Fischer, EM, Luterbacher, J, Trigo, RM, Garcia-Herrera, R. The hot summer of 2010: redrawing the temperature record map of Europe. Science 2011;332:220–4. https://doi.org/10.1126/science.1201224.Search in Google Scholar PubMed

16. Meehl, GA, Tebaldi, C. More intense, more frequent, and longer lasting heat waves in the 21st century. Science 2004;305:994–7. https://doi.org/10.1126/science.1098704.Search in Google Scholar PubMed

17. World Health Organization. Quantitative risk assessment of the effects of climate change on selected causes of death, 2030s and 2050s. Geneva: WHO; 2014.Search in Google Scholar

18. Noweir, MH, Bafail, AO, Jomoah, IM. Study of heat exposure during Hajj (pilgrimage). Environ Monit Assess 2008;147:279–95. https://doi.org/10.1007/s10661-007-0120-6.Search in Google Scholar PubMed

19. Ghaznawi, HI, Ibrahim, MA. Heatstroke and heat exhaustion in pilgrims performing the Haj (annual pilgrimage) in Saudi Arabia. Ann Saudi Med 1987;7:323–6. https://doi.org/10.5144/0256-4947.1987.323.Search in Google Scholar

20. Kang, S, Pal, JS, Eltahir, EAB. Future heat stress during Muslim pilgrimage (Hajj) projected to exceed “extreme danger” levels. Geophys Res Lett 2019;46:10094–100. https://doi.org/10.1029/2019gl083686.Search in Google Scholar

21. Saeed, F, Schleussner, C, Almazroui, M. From Paris to Makkah: heat stress risks for Muslim pilgrims at 1.5 °C and 2 °C. Environ Res Lett 2021;16:024037. https://doi.org/10.1088/1748-9326/abd067.Search in Google Scholar

22. Tagliacozzo, E, Toorawa, SM. The Hajj: pilgrimage in Islam. New York, NY: Cambridge University Press; 2016, xv:343 p.10.1017/CBO9781139343794Search in Google Scholar

23. Saudi Ministry of Municipal and Rural Affairs. Makkah City Profile. Saudi Arabia: Ministry of Municipal and Rural Affairs; 2019.Search in Google Scholar

24. Abdou, AEA. Temperature trend on Makkah, Saudi Arabia. Atmos Clim Sci 2014;4:457–81. https://doi.org/10.4236/acs.2014.43044.Search in Google Scholar

25. Yezli, S, Khan, A, Bouchama, A. Summer Hajj pilgrimage in the era of global warming: a call for vigilance and better understanding of the risks. J Trav Med 2019;26. https://doi.org/10.1093/jtm/taz069.Search in Google Scholar PubMed

26. Almazroui, M. Changes in temperature trends and extremes over Saudi Arabia for the period 1978–2019. Adv Meteorol 2020;2020:8828421. https://doi.org/10.1155/2020/8828421.Search in Google Scholar

27. Khan, K, Memish, ZA, Chabbra, A, Liauw, J, Hu, W, Janes, DA, et al.. Global public health implications of a mass gathering in Mecca, Saudi Arabia during the midst of an influenza pandemic. J Trav Med 2010;17:75–81. https://doi.org/10.1111/j.1708-8305.2010.00397.x.Search in Google Scholar PubMed

28. Ebrahim, SH, Memish, ZA, Uyeki, TM, Khoja, TA, Marano, N, McNabb, SJ. Public health. Pandemic H1N1 and the 2009 Hajj. Science 2009;326:938–40. https://doi.org/10.1126/science.1183210.Search in Google Scholar PubMed

29. Prasetyo, Y, Doewes, M, Rahma, N, Anantanyu, S. Effects of aerobic exercise and weight training-aerobic towards physical fitness of elderly Hajj candidates. Int J Adv Sci Eng Inf Technol 2017;7:106–17. https://doi.org/10.18517/ijaseit.7.1.1446.Search in Google Scholar

30. Yezli, S, Mushi, A, Almuzaini, Y, Balkhi, B, Yassin, Y, Khan, A. Prevalence of diabetes and hypertension among Hajj pilgrims: a systematic review. Int J Environ Res Publ Health 2021;18:1155.10.3390/ijerph18031155Search in Google Scholar PubMed PubMed Central

31. Al Shimemeri, A. Cardiovascular disease in Hajj pilgrims. J Saudi Heart Assoc 2012;24:123–7. https://doi.org/10.1016/j.jsha.2012.02.004.Search in Google Scholar PubMed PubMed Central

32. U.S. Food and Drugs Administration (FDA). The sun and your medicine. US: FDA; 2015. https://www.fda.gov/drugs/special-features/sun-and-your-medicine.Search in Google Scholar

33. Khan, ID, Khan, SA, Asima, B, Hussaini, SB, Zakiuddin, M, Faisal, FA. Morbidity and mortality amongst Indian Hajj pilgrims: a 3-year experience of Indian Hajj medical mission in mass-gathering medicine. J Infect Public Health 2018;11:165–70. https://doi.org/10.1016/j.jiph.2017.06.004.Search in Google Scholar PubMed PubMed Central

34. Yezli, S, Zaraa, S, Yassin, Y, Mushi, A, Stergachis, A, Khan, A. Medication utilization pattern among outpatients during the Hajj mass gathering. Saudi Pharmaceut J 2020;28:1122–8. https://doi.org/10.1016/j.jsps.2020.07.014.Search in Google Scholar PubMed PubMed Central

35. Sridhar, S, Benkouiten, S, Belhouchat, K, Drali, T, Memish, ZA, Parola, P, et al.. Foot ailments during Hajj: a short report. J Epidemiol Glob Health 2015;5:291–4. https://doi.org/10.1016/j.jegh.2014.12.007.Search in Google Scholar PubMed PubMed Central

36. Gautret, P, Bauge, M, Simon, F, Benkouiten, S, Valero, R, Parola, P, et al.. Overweight and obesity in French Hajj pilgrims. J Immigr Minority Health 2013;15:215–8. https://doi.org/10.1007/s10903-012-9583-9.Search in Google Scholar PubMed

37. Hoang, VT, Dao, TL, Ly, TDA, Sow, D, Belhouchat, K, Larbi Chaht, K, et al.. Gastrointestinal symptoms and the acquisition of enteric pathogens in Hajj pilgrims: a 3-year prospective cohort study. Eur J Clin Microbiol Infect Dis 2021;40:315–23. https://doi.org/10.1007/s10096-020-04018-z.Search in Google Scholar PubMed

38. Rashid, H, Abdul Muttalif, AR, Mohamed Dahlan, ZB, Djauzi, S, Iqbal, Z, Karim, HM, et al.. The potential for pneumococcal vaccination in Hajj pilgrims: expert opinion. Trav Med Infect Dis 2013;11:288–94. https://doi.org/10.1016/j.tmaid.2013.06.001.Search in Google Scholar PubMed

39. Khogali, M, Al Khawashki, MI. Heat stroke during the Makkah pilgrimage (Hajj). Saudi Med J 1981;2:85.Search in Google Scholar

40. Al-Aska, A, Yaqub, BA, Al-Harthi, SS, Al-Dalaan, A. Rapid cooling in management of heat stroke: clinical methods and practical implications. Ann Saudi Med 1987;7:135–8. https://doi.org/10.5144/0256-4947.1987.135.Search in Google Scholar

41. Alshehri, MA, Alzaidi, J, Alasmari, S, Alfaqeh, A, Arif, M, Alotaiby, SF, et al.. The prevalence and factors associated with musculoskeletal pain among pilgrims during the Hajj. J Pain Res 2021;14:369–80. https://doi.org/10.2147/jpr.s293338.Search in Google Scholar

42. Gautret, P, Yong, W, Soula, G, Gaudart, J, Delmont, J, Dia, A, et al.. Incidence of Hajj-associated febrile cough episodes among French pilgrims: a prospective cohort study on the influence of statin use and risk factors. Clin Microbiol Infect 2009;15:335–40. https://doi.org/10.1111/j.1469-0691.2009.02816.x.Search in Google Scholar PubMed PubMed Central

43. Yezli, S, Mushi, A, Yassin, Y, Maashi, F, Khan, A. Knowledge, attitude and practice of pilgrims regarding heat-related illnesses during the 2017 Hajj mass gathering. Int J Environ Res Publ Health 2019;16:3215. https://doi.org/10.3390/ijerph16173215.Search in Google Scholar PubMed PubMed Central

44. Yezli, S, Yassin, Y, Mushi, A, Maashi, F, Aljabri, N, Mohamed, G, et al.. Knowledge, attitude and practice (KAP) survey regarding antibiotic use among pilgrims attending the 2015 Hajj mass gathering. Trav Med Infect Dis 2019;28:52–8. https://doi.org/10.1016/j.tmaid.2018.08.004.Search in Google Scholar PubMed

45. Yezli, S, Zumla, A, Yassin, Y, Al-Shangiti, AM, Mohamed, G, Turkistani, AM, et al.. Undiagnosed active pulmonary tuberculosis among pilgrims during the 2015 Hajj mass gathering: a prospective cross-sectional study. Am J Trop Med Hyg 2017;97:1304–9. https://doi.org/10.4269/ajtmh.17-0271.Search in Google Scholar PubMed PubMed Central

46. Al Mayahi, ZK, Ali Kabbash, I. Perceptions of, and practices for coping with, heat exposure among male Arab pilgrims to the Hajj, 1436. Prehospital Disaster Med 2019;34:161–74. https://doi.org/10.1017/s1049023x19000025.Search in Google Scholar

47. Gardner, L, Miller, DM, Daly, C, Gupta, PK, House, C, Roiz de Sa, D, et al.. Investigating the genetic susceptibility to exertional heat illness. J Med Genet 2020;57:531–41. https://doi.org/10.1136/jmedgenet-2019-106461.Search in Google Scholar PubMed

48. Blows, WT. Crowd physiology: the ‘penguin effect.’ Accid Emerg Nurs 1998;6:126–9. https://doi.org/10.1016/s0965-2302(98)90025-x.Search in Google Scholar PubMed

49. Alnabulsi, H, Drury, J. Social identification moderates the effect of crowd density on safety at the Hajj. Proc Natl Acad Sci U S A 2014;111:9091–6. https://doi.org/10.1073/pnas.1404953111.Search in Google Scholar PubMed PubMed Central

50. Alfelali, M, Barasheed, O, Alshehri, J, Bokhary, H, Alsaedi, S, Alhamzi, A, et al.. Foot injuries among Hajj pilgrims with and without diabetes mellitus: implications for infection management. Infect Disord - Drug Targets 2014;14:140–7. https://doi.org/10.2174/1871526514666140713160413.Search in Google Scholar PubMed

51. Mandourah, Y, Al-Radi, A, Ocheltree, AH, Ocheltree, SR, Fowler, RA. Clinical and temporal patterns of severe pneumonia causing critical illness during Hajj. BMC Infect Dis 2012;12. https://doi.org/10.1186/1471-2334-12-117.Search in Google Scholar PubMed PubMed Central

52. Al-Ghamdi, MA. Assessment and improvement of thermal conditions inside pilgrimage tents and in Makkah in Saudi Arabia. UK: University of New Castle-Upon-Tnye; 1993. NE1-7RU.Search in Google Scholar

53. Hoang, VT, Gautret, P. Infectious diseases and mass gatherings. Curr Infect Dis Rep 2018;20:44. https://doi.org/10.1007/s11908-018-0650-9.Search in Google Scholar PubMed PubMed Central

54. Alzeer, AH. Respiratory tract infection during Hajj. Ann Thorac Med 2009;4:50–3. https://doi.org/10.4103/1817-1737.49412.Search in Google Scholar PubMed PubMed Central

55. Yousuf, M, Al-Saudi, DA, Sheikh, RA, Lone, MS. Pattern of medical problems among Haj pilgrims admitted to King Abdul Aziz Hospital, Madinah Al-Munawarah. Ann Saudi Med 1995;15:619–21. https://doi.org/10.5144/0256-4947.1995.619.Search in Google Scholar PubMed

56. Gautret, P, Benkouiten, S, Sridhar, S, Al-Tawfiq, JA, Memish, ZA. Diarrhea at the Hajj and Umrah. Trav Med Infect Dis 2015;13:159–66. https://doi.org/10.1016/j.tmaid.2015.02.005.Search in Google Scholar PubMed

57. Shakir, HA, Gazzaz, ZJ, Dhaffar, KO, Shahbaz, J. Outpatient services during (1423h) Hajj season. Sultan Qaboos Univ Med J 2006;6:47–50.Search in Google Scholar

58. Moghadamnia, MT, Ardalan, A, Mesdaghinia, A, Keshtkar, A, Naddafi, K, Yekaninejad, MS. Ambient temperature and cardiovascular mortality: a systematic review and meta-analysis. PeerJ 2017;5:e3574. https://doi.org/10.7717/peerj.3574.Search in Google Scholar PubMed PubMed Central

59. Li, J, Xu, X, Ding, G, Zhao, Y, Zhao, R, Xue, F, et al.. A cross-sectional study of heat wave-related knowledge, attitude, and practice among the public in the Licheng district of Jinan city, China. Int J Environ Res Publ Health 2016;13:648. https://doi.org/10.3390/ijerph13070648.Search in Google Scholar PubMed PubMed Central

60. Al-Zahrani, A, Al-Sulaiman, M, El Bushra, H. Risk factors for heat exhaustion among pilgrims to Makkah, Saudi Arabia, 1415. Saudi Epidemiol Bull 1995;2:1–4.Search in Google Scholar

61. AI-Rabeah, AM, EI-Bushra, HE, AI-Sayed, MO, Al-Saigul, AM, AI-Rasheedi, AA, AI-Mazam, AA, et al.. Behavioral risk factors for disease during Hajj: the second survey. Saudi Epidemiol Bull 1998;5:19–20.Search in Google Scholar

62. Al-Faify, SK, El Bushra, HE, AI-Wahaibi, SS, AlSalman, SA, BaOmer, AA, Khawajah, AA, et al.. Behavioral risk factors for pilgrims to Makkah, 1997. Saudi Epidemiol Bull 1998;5:3–7.Search in Google Scholar

63. AlMaghderi, Y, Al-joudi, A, Choudhry, AJ, Al-Rabeah, AM, Mohsin Ibrahim, M, Turkistani, AM. Behavioral risk factors for diseases during Hajj 1422 H (2002 G). Saudi Epidemiol Bull 2002;9:19–20.Search in Google Scholar

64. Al-Shihry, AM, Al-Khan, AA, Mohammed, AG. Pre-Hajj health-related advice, Makkah, 1999. Saudi Epidemiol Bull 1999;6:30–1.Search in Google Scholar

65. McMorris, T, Swain, J, Smith, M, Corbett, J, Delves, S, Sale, C, et al.. Heat stress, plasma concentrations of adrenaline, noradrenaline, 5-hydroxytryptamine and cortisol, mood state and cognitive performance. Int J Psychophysiol 2006;61:204–15. https://doi.org/10.1016/j.ijpsycho.2005.10.002.Search in Google Scholar PubMed

66. Armstrong, LE, Johnson, EC. Water intake, water balance, and the elusive daily water requirement. Nutrients 2018;10:1928. https://doi.org/10.3390/nu10121928.Search in Google Scholar PubMed PubMed Central

67. Alfaraj, N, Choudhry, AJ, Alhayani, O. Behavioral risk factors for disease, Hajj 1428 H/2007 G. Saudi Epidemiol Bull 2008;15:29–31.Search in Google Scholar

68. Armstrong, LE, De Luca, JP, Hubbard, RW. Time course of recovery and heat acclimation ability of prior exertional heatstroke patients. Med Sci Sports Exerc 1990;22:36–48. https://doi.org/10.1249/00005768-199002000-00007.Search in Google Scholar

69. Algeffari, M. Diabetes and Hajj pilgrims: a Narrative review of literature. J Pakistan Med Assoc 2019;69:879–84.Search in Google Scholar

70. BaDawood, AO, Bossei, AA, AlSabhani, MF, AlAhmari, SM, Shata, MT, Hamam, AF. The burden on EDs during Hajj due to pilgrim noncompliance with treatment for chronic conditions. SJEMed 2020;1:103–9. https://doi.org/10.24911/sjemed/72-1571844482.Search in Google Scholar

71. Alqahtani, AS, Althimiri, NA, BinDhim, NF. Saudi Hajj pilgrims’ preparation and uptake of health preventive measures during Hajj 2017. J Infect Public Health 2019;12:772–6. https://doi.org/10.1016/j.jiph.2019.04.007.Search in Google Scholar PubMed

72. Vimalavathini, R, Gitanjali, B. Effect of temperature on the potency & pharmacological action of insulin. Indian J Med Res 2009;130:166–9.Search in Google Scholar

73. Kupper, TE, Schraut, B, Rieke, B, Hemmerling, AV, Schoffl, V, Steffgen, J. Drugs and drug administration in extreme environments. J Trav Med 2006;13:35–47. https://doi.org/10.1111/j.1708-8305.2006.00007.x.Search in Google Scholar PubMed

74. Altebainawi, AF, Alrashidi, MN, Aljbreen, MK, Aziz, MM, Alhifany, AA, Aljofan, M, et al.. Association of medication storage with diabetes control: a cross-sectional study from Saudi Arabia. Saudi Pharmaceut J 2020;28:452–9. https://doi.org/10.1016/j.jsps.2020.02.006.Search in Google Scholar PubMed PubMed Central

75. Almuzaini, Y, Abdulmalek, N, Ghallab, S, Mushi, A, Yassin, Y, Yezli, S, et al.. Adherence of healthcare workers to Saudi management guidelines of heat-related illnesses during Hajj pilgrimage. Int J Environ Res Publ Health 2021;18:1156. https://doi.org/10.3390/ijerph18031156.Search in Google Scholar PubMed PubMed Central

Received: 2021-07-09
Accepted: 2021-10-17
Published Online: 2021-10-30
Published in Print: 2023-03-28

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 1.5.2024 from https://www.degruyter.com/document/doi/10.1515/reveh-2021-0097/html
Scroll to top button