Abstract
Objectives
To identify gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021.
Content
The risk of gestational complications was confirmed during SARS-CoV and MERS-CoV infection. However, this is not robust for COVID-19 because there is still no scientific evidence from longitudinal studies. A systematic review was performed using four databases, and 14 prospective or retrospective cohorts were finally included in the analysis.
Summary
The most frequently associated sociodemographic characteristic or comorbidity was the presence of any previous comorbidity (9 studies, 64.3%), followed by ethnicity and age (6 studies each one, 42.9%). The most frequently associated gestational complications in mothers were the admission to Intensive Care Unit (4 studies, 28.6%) and gestational age at delivery <37 weeks (3 studies, 21.4%). The most frequently associated gestational complications in newborns were preterm birth (4 studies, 28.6%) and the admission to Neonatal Intensive Care Unit (2 studies, 14.3%).
Outlook
Pregnant women infected with SARS-CoV-2 appear to have a higher risk of admission to Intensive Care Unit. Newborns of mothers infected with SARS-CoV-2 appear to have a higher risk of preterm birth and admission to Neonatal Intensive Care Unit.
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Research funding: Self-funded.
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Author contributions: GCRU formulated the research questions, designed the study, developed the preliminary search strategy, collected the articles, and drafted the manuscript. EESG and CRNM refined the search strategy incorporating new search terms and collected the articles. All authors critically reviewed the manuscript for relevant intellectual content and approved the final version.
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Competing interests: Authors declare they have no conflicts of interests.
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Informed consent: Not applicable.
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Ethical approval: Not applicable.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2022-0310).
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