Abstract
Objectives
The aim of this study was to evaluate the resilience of girls with central precocious puberty (CPP) during treatment with a gonadotropin-releasing hormone agonist (GnRHa) and compare these results with their healthy peers.
Methods
The Connor–Davidson Resilience Scale (CD-RISC) is a self-report scale used to quantify resilience, which is divided into seven subgroups (hardiness, coping, flexibility, purpose, optimism, regulation of emotion and cognition (REC), and self-efficacy). Fifty-one girls with CPP receiving GnRHa treatment and 51 healthy controls were involved in the study. Anthropometric measurements were evaluated and CD-RISC was performed at least six months after the initiation of GnRHa treatment.
Results
There was no statistically significant difference between the anthropometric evaluations of girls with CPP and the control group. Similarly, the total score and subgroup scores of patients with CPP and the control group showed no statistically significant difference. In the correlation analysis, there was a weak negative correlation between height and flexibility (r=−0.314 p=0.025), height SDS and flexibility (r=−0.254 p=0.092), height SDS, and purpose (r=−0.285 p=0.058). Also, there was a weak negative correlation between REC and weight (r=−0.435 p=0.003), REC and weight SDS (r=−0.461 p=0.002), REC and height (r=−0.269 p=0.077), REC and height SDS (r=−0.322 p=0.033), REC and BMI (r=−0.289 p=0.058), and REC and BMI SDS (r=−0.353 p=0.019).
Conclusions
The resilience of girls with CPP treated with GnRHa was found to be similar to their healthy peers. The early diagnosis of the disease and adequate treatment may decrease the discrepancy of somatic changes between girls with CPP and their peers, which may help them to overcome the stress of CPP and long-term treatment.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
References
1. Sultan, C, Gaspari, L, Maimoun, L, Kalfa, N, Paris, F. Disorders of puberty. Best Pract Res Clin Obstet Gynaecol 2018;48:62–89. https://doi.org/10.1016/j.bpobgyn.2017.11.004.Search in Google Scholar
2. Belchetz, PE, Plant, TM, Nakai, Y, Keogh, EJ, Knobil, E. Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science 1978;202:631–3. https://doi.org/10.1126/science.100883.Search in Google Scholar
3. Carel, JC, Eugster, EA, Rogol, A, Ghizzoni, L, Palmert, MR, ESPE-LWPES GnRH Analogs Consensus Conference Group, et al.. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 2009;123:e752–62. https://doi.org/10.1542/peds.2008-1783.Search in Google Scholar
4. Eugster, EA. Treatment of central precocious puberty. J Endocr Soc 2019;3:965–72. https://doi.org/10.1210/js.2019-00036.Search in Google Scholar
5. Patton, GC, Viner, R. Pubertal transitions in health. Lancet 2007;369:1130–9. https://doi.org/10.1016/s0140-6736(07)60366-3.Search in Google Scholar
6. Gluckman, PD, Hanson, MA. Evolution, development and timing of puberty. Trends Endocrinol Metabol 2006;17:7–12. https://doi.org/10.1016/j.tem.2005.11.006.Search in Google Scholar
7. Kaltiala-Heino, R, Marttunen, M, Rantanen, P, Rimpela, M. Early puberty is associated with mental health problems in middle adolescence. Soc Sci Med 2003;57:1055–64. https://doi.org/10.1016/s0277-9536(02)00480-x.Search in Google Scholar
8. Mendle, J, Harden, KP, Brooks-Gunn, J, Grabber, JA. Development’s tortoise and hare: pubertal timing, pubertal tempo and depressive symptoms in boys and girls. Dev Psychol 2010;46:1341–53. https://doi.org/10.1037/a0020205.Search in Google Scholar PubMed PubMed Central
9. Roberts, E, Joinson, C, Gunnel, D, Fraser, A, Mars, B. Pubertal timing and self-harm: a posrpective cohort analysis of males and females. Epidemiol Psychiatr Sci 2020;29:e170. https://doi.org/10.1017/S2045796020000839.Search in Google Scholar PubMed PubMed Central
10. Graber, JA. Pubertal timing and the development of psychopathology in adolescence and beyond. Horm Behav 2013;64:262–9. https://doi.org/10.1016/j.yhbeh.2013.04.003.Search in Google Scholar PubMed
11. Ehrhardt, AA, Meyer-Bahlburg, HF. Effects of prenatal sex hormones on gender-related behavior. Science 1981;211:1312–8. https://doi.org/10.1126/science.7209510.Search in Google Scholar PubMed
12. MacLusky, NJ, Naftolin, F. Sexual differentiation of the central nervous system. Science 1981;211:1294–302. https://doi.org/10.1126/science.6163211.Search in Google Scholar PubMed
13. Chen, M, Eugster, EA. Central precocious puberty: update on diagnosis and treatment. Paediatr Drugs 2015;17:273–81. https://doi.org/10.1007/s40272-015-0130-8.Search in Google Scholar PubMed PubMed Central
14. Bowes, L, Jaffee, SR. Biology, genes, and resilience: toward a multidisciplinary approach. Trauma Violence Abuse 2013;14:195–208. https://doi.org/10.1177/1524838013487807.Search in Google Scholar PubMed
15. Rutter, M. Implications of resilience concepts for scientific understanding. Ann N Y Acad Sci 2006;1094:1–12. https://doi.org/10.1196/annals.1376.002.Search in Google Scholar PubMed
16. Lemaire, P, Pierre, D, Bertrand, J-B, Brauner, R. A mathematical model for predicting the adult height of girls with advanced puberty after spontaneous growth. BMC Pediatr 2014;14:172. https://doi.org/10.1186/1471-2431-14-172.Search in Google Scholar PubMed PubMed Central
17. Calcaterra, V, Sampaolo, P, Klersy, C, Larizza, D, Alfei, A, Brizzi, V, et al.. Utility of breast ultrasonography in the diagnostic work-up of precocious puberty and proposal of a prognostic index for identifying girls with rapidly progressive central precocious puberty. Ultrasound Obstet Gynecol 2009;33:85–91. https://doi.org/10.1002/uog.6271.Search in Google Scholar PubMed
18. Demirbilek, H, Alikasifoglu, A, Gonc, EN, Ozon, A, Kandemir, N. Assessment of gonadotrophin suppression in girls treated with GnRH analogue for central precocious puberty; validity of single luteinizing hormone measurement after leuprolide acetate injection. Clin Endocrinol 2012;76:126–30. https://doi.org/10.1111/j.1365-2265.2011.04185.x.Search in Google Scholar PubMed
19. Fu, C, Leoutsakos, JM, Underwood, C. Moderating effects of a postdisaster intervention on risk and resilience factors associated with posttraumatic stress disorder in Chinese children. J Trauma Stress 2013;26:663–70. https://doi.org/10.1002/jts.21871.Search in Google Scholar PubMed
20. Iaipaolo, AS, Marusak, HA, Paulisin, SM, Sala-Hamrick, K, Crespo, LM, Elrahal, F, et al.. Distinct neural correlates of trait resilience within core neurocognitive networks in at-risk children and adolescents. Neuroimage Clin 2018;20:24–34. https://doi.org/10.1016/j.nicl.2018.06.026.Search in Google Scholar PubMed PubMed Central
21. Vetter, S, Dulaev, I, Mueller, M, Henley, RR, Gallo, WT, Kanukova, Z. Impact of resilience enhancing programs on youth surviving the Beslan school siege. Child Adolesc Psychiatr Ment Health 2010;4:11. https://doi.org/10.1186/1753-2000-4-11.Search in Google Scholar PubMed PubMed Central
22. Karairmak, O. Establishing the psychometric qualities of the Connor–Davidson Resilience Scale (CD-RISC) using exploratory and confirmatory factor analysis in a trauma survivor sample. J Psychiatr Res 2010;179:350–6.10.1016/j.psychres.2009.09.012Search in Google Scholar PubMed
23. Connor, KM, Davidson, JRT. Development of a new resilience scale: the Connor-Davidson resilience scale (CD-RISC). Depress Anxiety 2003;18:76–82. https://doi.org/10.1002/da.10113.Search in Google Scholar PubMed
24. Brooks-Gunn, J, Warren, MP. Biological and social contributions to negative affect in young girls. Child Dev 1989;60:40–55. https://doi.org/10.2307/1131069.Search in Google Scholar
25. Lewis, G, Ioannidis, K, van Harmelen, A-L, Neufeld, S, Stochl, J, Lewis, G, et al.. The association between pubertal status and depressive symptoms and diagnoses in adolescent females: a population-based cohort study. PloS One 2018;13: e0198804. https://doi.org/10.1371/journal.pone.0198804.Search in Google Scholar PubMed PubMed Central
26. Baumann, DA, Landolt, MA, Wetterwald, R, Dubuis, JM, Sizonenko, PC, Werder, EA. Psychological evaluation of young women after medical treatment for central precocious puberty. Horm Res 2001;56:45–50. https://doi.org/10.1159/000048089.Search in Google Scholar PubMed
27. Xhrouet-Heinrichs, D, Lagrou, K, Heinrichs, C, Craen, M, Dooms, L, Malvaux, P, et al.. Longitudinal study of behavioral and affective patterns in girls with central precocious puberty during long-acting triptorelin therapy. Acta Paediatr 1997;86:808–15. https://doi.org/10.1111/j.1651-2227.1997.tb08602.x.Search in Google Scholar PubMed
28. Schoelwer, MJ, Donahue, KL, Bryk, K, Didrick, P, Berenbaum, SA, Eugster, EA. Psychological assessment of mothers and their daughters at the time of diagnosis of precocious puberty. Int J Pediatr Endocrinol 2015;2015:5. https://doi.org/10.1186/s13633-015-0001-7.Search in Google Scholar PubMed PubMed Central
29. Schoelwer, MJ, Donahue, KL, Didrick, P, Eugster, EA. One-year follow-up of girls with precocious puberty and their mothers: do psychological assessments change over time or with treatment? Horm Res Paediatr 2017;88:347–53. https://doi.org/10.1159/000479688.Search in Google Scholar PubMed PubMed Central
30. Yu, R, Yang, S, Hwang, IT. Psychological effects of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty. J Pediatr Endocrinol Metab 2019;32:1071–5. https://doi.org/10.1515/jpem-2019-0108.Search in Google Scholar PubMed
31. Menk, TAS, Inacio, M, Macedo, DB, Bessa, DS, Latronico, AC, Mendonca, B, et al.. Assessment of stress levels in girls with central precocious puberty before and during long- acting gonadotropin-releasing hormone agonist treatment: a pilot study. J Pediatr Endocrinol Metab 2017;30:657–62. https://doi.org/10.1515/jpem-2016-0425.Search in Google Scholar
32. Zheng, F, Zhu, H, Jiang, YJ. Psychological behavior of girls with idiopathic central precocious puberty before and after treatment with gonadotropin-releasing hormone analogue. Zhejiang Da Xue Xue Bao Yi Xue Ban 2008;37:289–94.Search in Google Scholar
33. Kim, YJ, Lee, HS, Lee, YJ, Lim, JS, Kim, SY, Kim, EY, et al.. Multicenter clinical trial of leuprolide acetate depot (Luphere depot 3.75 mg) for efficacy and safety in girls with central precocious puberty. Ann Pediatr Endocrinol Metab 2013;18:173–8. https://doi.org/10.6065/apem.2013.18.4.173.Search in Google Scholar
34. Wojniusz, S, Callens, N, Sütterlin, S, Andersson, S, Schepper, JD, Gies, I, et al.. Cognitive, emotional, and psychosocial functioning of girls treated with pharmacological puberty blockage for idiopathic central precocious puberty. Front Psychol 2016;7:1053. https://doi.org/10.3389/fpsyg.2016.01053.Search in Google Scholar
35. Eisenberg, N, Fabes, RA, Guthrie, IK, Reiser, M. Dispositional emotionality and regulation: their role in predicting quality of social functioning. J Pers Soc Psychol 2000;78:136–57. https://doi.org/10.1037/0022-3514.78.1.136.Search in Google Scholar
36. Gross, JJ, Thompson, RA. Emotion regulation: conceptual foundations. In: Gross, JJ, editor. Handbook of emotion regulation. New York: The Guilford Pres; 2007. p. 3–24.Search in Google Scholar
37. Prefit, A-B, Mirela Cândea, D, Szentagotai-Tătar, A. Emotion regulation across eating pathology: a meta-analysis. Appetite 2019;143:104438. https://doi.org/10.1016/j.appet.2019.104438.Search in Google Scholar
38. Percinel, I, Ozbaran, B, Kose, S, Simsek, DG, Darcan, S. Increased deficits in emotion recognition and regulation in children and adolescents with exogenous obesity. World B Biol Psychiatry 2018;19:112–8. https://doi.org/10.1080/15622975.2016.1265147.Search in Google Scholar
39. Garnefski, N, Teerds, J, Kraaij, V, Legerstee, J, van den Kommer, T. Cognitive emotion regulation strategies and depressive symptoms: differences between males and females. Pers Indiv Differ 2004;36:267–76. https://doi.org/10.1016/s0191-8869(03)00083-7.Search in Google Scholar
40. Gross, JJ. Emotion regulation: current status and future prospects. Psychol Inq 2015;26:1–26. https://doi.org/10.1080/1047840x.2014.940781.Search in Google Scholar
41. Lutz, LJ, Gaffney-Stomberg, E, Williams, WK, McGraw, SM, Niro, PJ, Karl, JP, et al.. Adherence to the dietary guidelines for Americans is associated with psychological resilience in young adults: a cross-sectional study. J Acad Nutr Diet 2017;117:396–403. https://doi.org/10.1016/j.jand.2016.09.018.Search in Google Scholar PubMed
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