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131 Metabolomics/Metabonomics

From: Glossary and Tutorial of Xenobiotic Metabolism Terms Used During Small Molecule Drug Discovery and Development

  • Paul Erhardt , Kenneth Bachmann , Donald Birkett , Michael Boberg , Nicholas Bodor , Gordon Gibson , David Hawkins , Gabrielle Hawksworth , Jack Hinson , Daniel Koehler , Brian Kress , Amarjit Luniwal , Hiroshi Masumoto , Raymond Novak , Phillip Portoghese , Jeffrey Sarver , M. Teresa Serafini , Christopher Trabbic , Nico Vermeulen and Steven Wrighton

Abstract

This project originated more than 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta-testing that, fortuitously, engaged international audiences in a wide range of disciplines involved in drug discovery and development. It became clear that the inclusion of information to enhance discussions among this mix of participants would be even more valuable. The present version retains a chemical structure theme while expanding tutorial comments that aim to bridge the various perspectives that may arise during interdisciplinary communications about a given term. This glossary is intended to be educational for early stage researchers, as well as useful for investigators at various levels who participate on today’s highly multidisciplinary, collaborative small molecule drug discovery teams.

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