Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter October 23, 2020

Monoamniotic twins pregnancy complicated by a fetal congenital heart defect – a challenge for perinatal decisions

  • Monika Pasieczna ORCID logo , Joanna Kuran-Ohde , Anna Kajdy ORCID logo , Dagmara Filipecka-Tyczka ORCID logo , Natalia Świątek and Joanna Szymkiewicz-Dangel ORCID logo

Abstract

Objectives

To analyze pregnancy management and postnatal follow-up in monochorionic monoamniotic (MCMA) pregnancies complicated by a congenital heart defect (CHD) in one twin and to compare the results with current recommendations concerning time and mode of delivery in MCMA pregnancies.

Cases presentation

Perinatal medical records of five pairs of monoamniotic twins referred to Fetal Cardiology Department were analyzed. 5 out of 23 MCMA pregnancies (21.7%) were complicated by CHD in one fetus. Cesarean section (CS) was performed between 32 and 35 weeks of gestation (WoG). 9 out of 10 neonates had respiratory failure, including all patients with CHD. Twins without congenital abnormalities spent median 21 days (range 10–40 days) in neonatal units. Patients with CHD were transferred to cardiology departments on average 6th day of life. All were operated on later than term-born neonates, 4 out of 5 required stage surgery and their median stay in the hospital was 75 days (range 48–106 days).

Conclusions

According to current recommendations, delivery in MCMA pregnancies should be scheduled at 32–34 weeks. In cases complicated by CHD in one twin, such early delivery complicates surgical treatment and may affect the final outcome. Low body weight and respiratory disorders increase the risk of complications in the perioperative period and prolong hospitalization.


Corresponding author: Monika Pasieczna, MD, 2nd Department of Obstetrics and Gynecology, Medical University of Warsaw, Karowa Street 2, 00-315, Warsaw, Poland, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The Ethical Committee of the Medical University of Warsaw approved the study.

References

1. Martin, JA, Hamilton, BE, Osterman, MJ. Three decades of twin births in the United States, 1980–2009. NCHS Data Brief 2012;80:1–8. 22617378.Search in Google Scholar PubMed

2. Burn, J, Corney, G. Congenital heart defects and twinning. Acta Genet Med Gemellol 1984;33:61–9. https://doi.org/10.1017/s0001566000007510.Search in Google Scholar PubMed

3. Manning, N, Archer, N. A study to determine the incidence of structural congenital heart disease in monochorionic twins. Prenat Diagn 2006;26:1062–4. https://doi.org/10.1002/pd.1556.Search in Google Scholar PubMed

4. Hack, KE, Derks, JB, Schaap, AH, Lopriore, E, Elias, SG, Arabin, B, et al. Perinatal outcome of monoamniotic twin pregnancies. Obstet Gynecol 2009;113:353–60. https://doi.org/10.1097/aog.0b013e318195bd57.Search in Google Scholar PubMed

5. Group, MW. Inpatient vs outpatient management and timing of delivery of uncomplicated monochorionic monoamniotic twin pregnancy: the MONOMONO study. Ultrasound Obstet Gynecol 2019;53:175–83. https://doi.org/10.1002/uog.19179.Search in Google Scholar PubMed

6. D’Antonio, F, Odibo, A, Berghella, V, Khalil, A, Hack, K, Saccone, G, et al. Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2019;53:166–74. https://doi.org/10.1002/uog.20100.Search in Google Scholar PubMed

7. Glinianaia, SV, Rankin, J, Khalil, A, Binder, J, Waring, G, Sturgiss, SN, et al. Prevalence, antenatal management and perinatal outcome of monochorionic monoamniotic twin pregnancy: a collaborative multicenter study in England, 2000–2013. Ultrasound Obstet Gynecol 2019;53:184–92. https://doi.org/10.1002/uog.19114.Search in Google Scholar PubMed

8. Prefumo, F, Fichera, A, Pagani, G, Marella, D, Valcamonico, A, Frusca, T. The natural history of monoamniotic twin pregnancies: a case series and systematic review of the literature. Prenat Diagn 2015;35:274–80. https://doi.org/10.1002/pd.4538.Search in Google Scholar PubMed

9. Baxi, LV, Walsh, CA. Monoamniotic twins in contemporary practice: a single-center study of perinatal outcomes. J Matern Fetal Neonatal Med 2010;23:506–10. https://doi.org/10.3109/14767050903214590.Search in Google Scholar PubMed

10. Khalil, A, Rodgers, M, Baschat, A, Bhide, A, Gratacos, E, Hecher, K, et al. ISUOG practice guidelines: role of ultrasound in twin pregnancy. Ultrasound Obstet Gynecol 2016;47:247–63. https://doi.org/10.1002/uog.15821.Search in Google Scholar PubMed

11. Shub, A, Walker, SP. Planned early delivery versus expectant management for monoamniotic twins. Cochrane Database Syst Rev 2015;4:CD008820. https://doi.org/10.1002/14651858.CD008820.pub2.Search in Google Scholar PubMed PubMed Central

12. Roque, H, Gillen-Goldstein, J, Funai, E, Young, BK, Lockwood, CJ. Perinatal outcomes in monoamniotic gestations. J Matern Fetal Neonatal Med 2003;13:414–21. https://doi.org/10.1080/jmf.13.6.414.421.Search in Google Scholar PubMed

13. Fenton, TR, Kim, JH. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr 2013;13:59. https://doi.org/10.1186/1471-2431-13-59.Search in Google Scholar PubMed PubMed Central

14. Hadlock, FP, Harrist, RB, Martinez-Poyer, J. Utero analysis of fetal growth: a sonographic weight standard. Radiology 1991;181:129–33. https://doi.org/10.1148/radiology.181.1.1887021.Search in Google Scholar PubMed

15. Allen, VM, Windrim, R, Barrett, J, Ohlsson, A. Management of monoamniotic twin pregnancies: a case series and systematic review of the literature. Brit J Obstet Gynaecol 2001;108:931–6. https://doi.org/10.1111/j.1471-0528.2001.00216.x.Search in Google Scholar PubMed

16. Management of Monochorionic Twin Pregnancy. Green-top guideline No. 51. Brit J Obstet Gynaecol 2017;124:e1–e45. https://doi.org/10.1111/1471-0528.14188.Search in Google Scholar PubMed

17. American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine. ACOG Practice Bulletin No. 144: multifetal gestations: twin, triplet, and higher-order multifetal pregnancies. Obstet Gynecol 2014;123:1118–32. https://doi.org/10.1097/01.AOG.0000446856.51061.3e.Search in Google Scholar PubMed

18. Boyle, EM, Poulsen, G, Field, DJ, Kurinczuk, JJ, Wolke, D, Alfirevic, Z, et al. Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study. Brit Med J 2012;344:e896. https://doi.org/10.1136/bmj.e896.Search in Google Scholar PubMed PubMed Central

19. Quigley, MA, Poulsen, G, Boyle, E, Wolke, D, Field, D, Alfirevic, Z, et al. Early term and late preterm birth are associated with poorer school performance at age 5 years: a cohort study. Arch Dis Child Fetal Neonatal Ed 2012;97:F167–73. https://doi.org/10.1136/archdischild-2011-300888.Search in Google Scholar PubMed

20. Van Mieghem, T, De Heus, R, Lewi, L, Klaritsch, P, Kollmann, M, Baud, D, et al. Prenatal management of monoamniotic twin pregnancies. Obstet Gynecol 2014;124:498–506. https://doi.org/10.1097/aog.0000000000000409.Search in Google Scholar

21. Malik, S, Bird, TM, Jaquiss, RD, Morrow, WR, Robbins, JM. Comparison of in-hospital and longer-term outcomes of hybrid and Norwood stage 1 palliation of hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 2015;150:474–80 e2. https://doi.org/10.1016/j.jtcvs.2015.06.071.Search in Google Scholar PubMed

22. Jacobs, JP, Mayer, JEJr, Pasquali, SK, Hill, KD, Overman, DM, St Louis, JD, et al. The society of thoracic Surgeons congenital heart surgery Database: 2019 update on outcomes and quality. Ann Thorac Surg 2019;107:691–704. https://doi.org/10.1016/j.athoracsur.2018.12.016.Search in Google Scholar

23. Newburger, JW, Wypij, D, Bellinger, DC, du Plessis, AJ, Kuban, KC, Rappaport, LA, et al. Length of stay after infant heart surgery is related to cognitive outcome at age 8 years. J Pediatr 2003;143:67–73. https://doi.org/10.1016/s0022-3476(03)00183-5.Search in Google Scholar

24. Chu, PY, Li, JS, Kosinski, AS, Hornik, CP, Hill, KD. Congenital heart disease in premature infants 25–32 Weeks’ gestational age. J Pediatr 2017;181:37–41 e1. https://doi.org/10.1016/j.jpeds.2016.10.033.Search in Google Scholar PubMed PubMed Central

25. Cheng, HH, Almodovar, MC, Laussen, PC, Wypij, D, Polito, A, Brown, DW, et al. Outcomes and risk factors for mortality in premature neonates with critical congenital heart disease. Pediatr Cardiol 2011;32:1139–46. https://doi.org/10.1007/s00246-011-0036-3.Search in Google Scholar PubMed

26. Best, KE, Tennant, PWG, Rankin, J. Survival, by birth weight and gestational age, in individuals with congenital heart disease: a population-based study. J Am Heart Assoc 2017;6:7. https://doi.org/10.1161/jaha.116.005213.Search in Google Scholar PubMed PubMed Central

27. Dees, E, Lin, H, Cotton, RB, Graham, TP, Dodd, DA. Outcome of preterm infants with congenital heart disease. J Pediatr 2000;137:653–9. https://doi.org/10.1067/mpd.2000.108568.Search in Google Scholar PubMed

28. Curzon, CL, Milford-Beland, S, Li, JS, O’Brien, SM, Jacobs, JP, Jacobs, ML, et al. Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of the Society of Thoracic Surgeons Congenital Heart Database. J Thorac Cardiovasc Surg 2008;135:546–51. https://doi.org/10.1016/j.jtcvs.2007.09.068.Search in Google Scholar PubMed

Received: 2020-03-18
Accepted: 2020-09-18
Published Online: 2020-10-23

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 11.6.2024 from https://www.degruyter.com/document/doi/10.1515/crpm-2020-0022/html
Scroll to top button