Acknowledgments
The authors would like to thank Cecilia Maldonado, Manuel Ibarra, and Marianela Lorier (Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Uruguay) for their valuable assistance in conducting this study.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The authors acknowledge financial support by University of Barcelona (Grant APIF-2010, predoctoral research grant for conducting training periods in Spain and abroad for 2013).
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Hiemke C, Baumann P, Bergemann N, Conca A, Dietmaier O, Egberts K, et al. AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011. Pharmacopsychiatry 2011;44:195–235.10.1055/s-0031-1286287Search in Google Scholar
2. Hsu YC, Chen BG, Yang SC, Wang YS, Huang SP, Huang MH, et al. Methadone concentrations in blood, plasma, and oral fluid determined by isotope-dilution gas chromatography-mass spectrometry. Anal Bioanal Chem 2013;405:3921–8.10.1007/s00216-012-6460-2Search in Google Scholar
3. Shiran MR, Hassanzadeh-Khayyat M, Iqbal MZ, Lagundoye O, Seivewright N, Lennard MS, et al. Can saliva replace plasma for the monitoring of methadone? Ther Drug Monit 2005;27: 580–6.10.1097/01.ftd.0000164392.01779.dbSearch in Google Scholar
4. Wolff K, Hay A, Raistrick D. Methadone in saliva. Clin Chem 1991;37:1297–8.10.1093/clinchem/37.7.1297Search in Google Scholar
5. Kang GI, Abbott FS. Analysis of methadone and metabolites in biological fluids with gas chromatography mass spectrometry. J Chromatogr 1982;231:311–20.10.1016/S0378-4347(00)81856-3Search in Google Scholar
6. Choo RE, Huestis MA. Oral fluid as a diagnostic tool. Clin Chem Lab Med 2004;42:1273–87.Search in Google Scholar
7. Fagiolino P, Vázquez M, Maldonado C, Ruiz ME, Volonté MG, Orozco-Suárez S, et al. Usefulness of salivary drug monitoring for detecting efflux transporter overexpression. Curr Pharm Des 2013;19:6701–8.10.2174/13816128113199990368Search in Google Scholar PubMed
8. Miguez-Díez E, Modamio P, Lastra CF, Arrufat FX, Serra M, Reig S, et al. Development and validation of a rapid and reliable high-performance liquid chromatography method for methadone quantification in human plasma and saliva. Clin Chem Lab Med 2013;51:e309–12.10.1515/cclm-2013-0546Search in Google Scholar PubMed
9. Lynn RK, Olsen GD, Leger RM, Gordon WP, Smith RG, Gerber N. The secretion of methadone and its major metabolite in the gastric juice of humans: comparison with blood and salivary concentrations. Drug Metab Dispos 1976;4:504–9.Search in Google Scholar
10. Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet 2002;41:1153–93.10.2165/00003088-200241140-00003Search in Google Scholar PubMed
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