High Performance Liquid Chromatography: Theory, Instrumentation and Application in Drug Quality Control

Omar Al Sayed Omar; Moustafa A. Khalifa

Published by De Gruyter 2022

High Performance Liquid Chromatography

Theory, Instrumentation and Application in Drug Quality Control

Omar Al Sayed Omar and Moustafa A. Khalifa

https://doi.org/10.1515/9783110529456

Overview
Contents

About this book

During the past decade, modern high-performance liquid chromatography (HPLC) utilization has expanded greatly, especially in the quality control of pharmaceutical products in drug quality control laboratories. This book provides an extensive collection of technical information about HPLC-Columns (physicochemical properties and chromatographic characteristics), from various manufacturers, and helps analysts to decide on the ideal approach for their analysis according to the requirements of drug manufacturers specifi cations and the desired Pharmacopeia. In addition, the authors give practical advice on how to prepare mobile phases, choose a suitable detector, and set up an HPLC analysis. This book is comprehensive for the average professional or technician who plans to work with modern HPLC. This book is useful for most Drug Quality Control Laboratories where modern HPLC is utilized. Following a hands-on approach, the book gives key insights into the pharmaceutical applications of HPLC and the latest requirements of the major regulatory agencies such as ICH, FDA, or USP.

A complete reference guide to pharmaceutical HPLC analysis.
Highlights the latest developments and novel approaches in HPLC.
Explains method development and how to interpret the results of analysis.
Contains a chapter on HPLC safety.

Author / Editor information

M. A. Khalifa and Omar Al Syed Omar, Drug and Food Quality Control Laboratories, Ministry of Health, Kuwait.

Topics

Frontmatter Publicly Available Download PDF	I
Preface Publicly Available Download PDF	V
Contents Publicly Available Download PDF	IX
1 High-performance liquid chromatography (HPLC): theoretical principles Requires Authentication Unlicensed Licensed Download PDF	1
2 HPLC columns for pharmaceutical analysis Requires Authentication Unlicensed Licensed Download PDF	17
3 HPLC mobile phase and HPLC pumping system Requires Authentication Unlicensed Licensed Download PDF	95
4 HPLC injection system (injector) Requires Authentication Unlicensed Licensed Download PDF	133
5 HPLC detectors Requires Authentication Unlicensed Licensed Download PDF	143
6 HPLC as analytical tool in drug quality control laboratories: getting started Requires Authentication Unlicensed Licensed Download PDF	169
7 Preparation of pharmaceutical samples for HPLC analysis in drug quality control laboratories Requires Authentication Unlicensed Licensed Download PDF	197
8 HPLC as analytical tool in drug quality control laboratories: qualitative and quantitative analysis Requires Authentication Unlicensed Licensed Download PDF	217
9 HPLC–Mass Spectrometry (HPLC–MS) and its applications in drug quality control laboratories Requires Authentication Unlicensed Licensed Download PDF	309
10 Safety in HPLC laboratories Requires Authentication Unlicensed Licensed Download PDF	343
11 Glossary Requires Authentication Unlicensed Licensed Download PDF	369
Index Requires Authentication Unlicensed Licensed Download PDF	377

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Analytical Chemists, Organic Chemists, Pharmaceutical Chemists, Quality Control lab workers, Pharmacists.
Pages
- Front matter: 16
- Main content: 306
Illustrations
- Illustrations: 139
- Coloured Illustrations: 84
- Tables: 30
Keywords: Analytical Chemistry; HPLC; Analytical Instrument; Chromatography

eBook

Published: February 21, 2022
ISBN: 9783110529456

Paperback

Published: March 7, 2022
ISBN: 9783110528800