To elucidate the role of upper respiratory virus to bronchial asthma, the studies on anti-adeno virus 3 antibody titer and anti-parainfluenza virus titer were carried out with the 210 cases of bronchial asthma and 21 cases of normal subjects by means of complement fixation test and HI test. Anti-influenza virus titer were carried out with 12 cases of bronchial asthem by means of HI test.
The results were as follows;
1) Anti-adeno viral titer of the patients with bronchial asthma showed to be higher than that of normal subjects (p<0.01) . Also anti-para influenza viral titer was significant difference between former and later (p<0.01) .
2) The titer of the asthma patients of infectious types or mixed types was higher than that of atopic types.
3) In winter, anti-viral titer showed to be higher, and correlated to the predisponsing season of the upper respiratory viral infection.
4) There is no statistical difference between steroid-receiving patients and no steroid in anti-viral titer. IgE globulin levels showed to be high in atopic types compared to the other types.
5) In generally, clinical states in bronchical asthma were tendency to improve, accompanied with increasing serum anti-viral titer by vaccination therapy in gradual increase of dosage.
6) In 79 percent of the patients were effective in influenza vaccination therapy.
7) The mechanism of inflenza vaccination treatment was suggested, to act the hyposensitizing effects as well as the protect their infection.