In this study, we investigated the superoxide dismutase (SOD) activity in serum of normal human subject and the relation between renal disease and SOD activity, Normal range of the total SOD activity was 1.94±0.90U/ml (mean±2SD) in male (n=105) and 1.63±0.66U/ml in female (n=54), Mn-SOD activity was 0.83±0.42U/ml in male (n=105) and 0.99±0.26U/ml in female (n=54), There were significant difference between male and female.
The correlation between creatinine and Cu, Zu-SOD showed a good correlation (r=0.601), However, Mn-SOD was poorly correlated (r=0.396), A patients with renal insufficiency had markedly high Cu. Zn-SOD activity and creatinine concentration, After renal transplantation, Cu, Zn-SOD activity decreased parallel with the decrease of creatinine concentration.
The urinary protein showed a positive correlation with urnary Cu, Zn-SOD (r=0.569) and negative correlation with urinary Mn-SOD (r=-0.553).