日本腎臓学会誌
Online ISSN : 1884-0728
Print ISSN : 0385-2385
ISSN-L : 0385-2385
腎障害に対する脂質代謝異常の影響
近藤 修市吉澤 信行大嶋 智竹内 昭彦久保田 孝雄押川 泰浩尾田 高志明石 好弘鈴木 康史清水 栄一清水 潤丹羽 寛文
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1991 年 33 巻 7 号 p. 659-664

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To clarify the effect of abnormal lipid metabolism and lipid deposition in glomerular injuries, we conducted clinical and pathological examination of various glomerulonephritis. There was no relationship between serum TC, TG or apo B and renal deposition of apo B or TG in glomerulonephritis. Apo B staining was intense for MCNS but was very weak for FGS. The staining was more intense in higher grade of glomerular injury in IgAN. Apo B demonstrated a specific pattern for MN, MPGN and lupus nephritis . These data suggest that apo B deposition reflects disturbance of glomerular permselectivity of macromolecules including abnormal influx, transport and endocytosis of macromolecules.

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