日本腎臓学会誌
Online ISSN : 1884-0728
Print ISSN : 0385-2385
ISSN-L : 0385-2385
腎臓移植後のネフローゼ症候群に関する臨床的研究
両角 國男吉田 篤博新村 育夫石井 高博及川 理藤浪 隆夫後藤 泉宗宮 信賢宮井 宏暢山田 宣夫打田 和治加納 忠行冨永 芳博河合 真千夫大倉 誉暢高木 弘
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1985 年 27 巻 11 号 p. 1523-1534

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Proteinuria and nephotic syndrome frequently occur after renal transplantation We analyzed clinical and histo-pathologic data from 14 recipients (12 living and 2 cadaveric) who developed nephotic syndrome out of 90 living and 11 cadaveric renal grafts surviving over 3 months. Nephrotic syndrome was developed at 22.4 (mean) months post-transplant (range, 3 to 65 months) . The cause of nephrotic syndrome was attributed to transplant glomerulopathy of chronic rejection in 13 recipients and 1 case of renal vein thrombosis. After the onset of nephrotic syndrome, graft f unction deteriorated rapidly, with a 1 year graft surval of 36% and a 2 year graft survival of 10%. Histological characteristics of transplant glomerulopathy was variable capillary wall lesion. Multiple splitting of glomerular capillary wall as a result of subendothelial cell injury and expansion of subendothelial electron lucent layer was common finding.

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