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Vol. 31 No. 4 (2019): Vol 31 Issue 4

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Synthesis, Characterization and Antimicrobial Screening of Novel Hydrazide Ligand & It’s Transition Metal Complexes

https://doi.org/10.14233/ajchem.2019.21795
S.P. Bhale1
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com
A.R. Yadav1
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com
S.U. Tekale1
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com
R.B. Nawale2
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com
R.P. Marathe2
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com
P.S. Kendrekar3
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com
R.P. Pawar1
1Department of Chemistry, Deogiri College, Aurangabad-431005, India 2Department of Chemistry, Government College of Pharmacy, Aurangabad-431005, India 3Department of Health Sciences, Central University of Technology, Bloemfontein 9033, Free State, South Africa *Corresponding author: E-mail: rppawar@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 4 (2019): Vol 31 Issue 4

Abstract

Different transition metal complexes were synthesized from novel 3-bromo-2-[1-(4-hydroxy-6-methyl- 2-oxo-2H-pyran-3-yl)ethylidene]hydrazide ligand (H2L) and characterized by spectral techniques. The synthesized ligand was found to act mono as well as di deprotonated (OH, NH) manner and stoichiometry of the ligand to metal ions was confirmed to be 1:1 in case of complex using metal chloride salts, whereas 1:2 in case of metal(II) complexes using metal acetate(II) salt. Structures of metal complexes were confirmed by IR, 1H NMR, TGA, XRD, elemental analysis and UV technique which revealed that Mn(II), Co(II), Ni(II), Cu(II) complexes were octahedral geometry and those of Cu(II), Zn(II) showed square planner and tetrahedral geometry around metal ion respectively. Furthermore H2L and its metal complexes were screened for antimicrobial activity which showed that ligand enhanced its biological activity after coordination with metal ions. In particular, Cd(II) and Mn(II) complexes exhibited excellent antifungal activity.

Keywords

ONO donor ligand Transition metal complexes Antimicrobial
Bhale1, S., Yadav1, A., Tekale1, S., Nawale2, R., Marathe2, R., Kendrekar3, P., & Pawar1, R. (2019). Synthesis, Characterization and Antimicrobial Screening of Novel Hydrazide Ligand & It’s Transition Metal Complexes. Asian Journal of Chemistry, 31(4), 938–942. https://doi.org/10.14233/ajchem.2019.21795
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