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Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset

Published online by Cambridge University Press:  21 February 2012

Christopher Oldmeadow ,
Kerrie Mengersen ,
Nicholas Martin  and
David L. Duffy
Christopher Oldmeadow*
Affiliation:
Department of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia. c.oldmeadow@student.qut.edu.au
Kerrie Mengersen
Affiliation:
Department of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia.
Nicholas Martin
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
David L. Duffy
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia.
*
*Address for correspondence: Chris Oldmeadow, Queensland University of Technology, Mathematical Sciences, O Block, Gardens Point Campus, Brisbane, Australia.

Abstract

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Appendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3.

Keywords

appendicitisage at onsetlinkage analysissurvivalheritability
Type
Articles
Information
Twin Research and Human Genetics , Volume 12 , Issue 2: SPECIAL SECTION: Genes for Health Meeting 2009 , 01 April 2009 , pp. 150 - 157
Copyright
Copyright © Cambridge University Press 2009