Reinforcement amid genetic diversity in the Candida albicans biofilm regulatory network
Fig 4
Panel A. Relative expression levels of selected 17-strain principal direct and indirect targets. Direct targets are genes whose 5’ regions are bound by Efg1; indirect targets are genes whose 5’ regions are not detectably bound by Efg1 [11–13]. RNA expression levels were calculated relative to the efg1Δ/Δ for each TDH3-TF strain under strong hypha-inducing conditions (RPMI+10% FBS at 37°C). Selected genes were those with a conserved response to a TDH3-TF mutation in the SC5314, P87, and P75010 backgrounds. Shown here are the relative expression levels for these genes in SC5314 background. Panel B. Expression levels of BRG1, UME6, and WOR3 relative to WT in both the efg1Δ/Δ mutant and in each efg1Δ/Δ TDH3-TF strain in the SC5314 isolate background. P-values for significance are given in S6 Table.