The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
Fig 2
Dynamics of CD101-expressing CD4 T cells after SIV infection.
A) Representative staining of CD101 on PBMC memory CD4 pre- and post-SIV infection. B) Expression levels of CD101 on PBMC memory CD4 pre- and post-SIV infection. C) Total loss of CD101+ and CD101- cells within CD4 subsets calculated based on absolute counts in blood pre- and post-SIV infection (mean+SEM). D) Representative staining of CD101 on PBMC CD4 Tregs pre- and post-SIV infection. E) Expression levels of CD101 on PBMC CD4 Tregs pre- and post-SIV infection. F) Expression levels of CD101 on PBMC CD4 Tregs from HIV-infected individuals during active viremia and during suppressive antiretroviral therapy (ART). G) Representative staining of CD101 on rectal biopsy (RB) memory CD4 pre- and post-SIV infection. H) Expression levels of CD101 on RB memory CD4 pre- and post-SIV infection. I) Expression levels of α4β7 and CCR5 on RB memory CD4 CD101- and CD101+ cells from healthy RM. J) Association between depletion of CD101+ CD4 T cells in rectal biopsies at day 14 p.i. (calculated from baseline to acute infection as % of live lymphocytes) and SIV DNA levels in rectal biopsies at day 14 p.i. (spearman correlation, n = 9). K) CD101 expression within PBMC CD4 subsets during longitudinal SIV infection (mean±SEM). L) Overall contribution of CD101+ cells to the overall CD4 pool from each PBMC CD4 subset during longitudinal SIV infection (mean±SEM). Lines designate mean values.