Selective modulation of cell surface proteins during vaccinia infection: A resource for identifying viral immune evasion strategies
Fig 9
HCMV and VACV commonly target a subset of PM proteins.
(A) Overlap of proteins downregulated according to ‘sensitive’ criteria after infection with VACV or HCMV (S6A Table). ‘Sensitive’ criteria HCMV PMP (n = 2) [29]: human PM- (GO terms PM/CS/XC/ShG) proteins quantified in a single or both replicates and showing on average >2 FC at any time-point (24, 48, 72 hpi) compared to (average of) mock sample(s). (B) Functional enrichment within proteins commonly downregulated from cell surface during VACV or HCMV infection (‘sensitive’ criteria). A background of all proteins detected in at least one replicate of both PMP VACV and PMP HCMV was used. Shown are representative terms from each cluster with a Benjamini-Hochberg-corrected p-value of <0.05 (S6B Table). (C) Temporal profiles of selected proteins commonly downregulated from the cell surface after VACV or HCMV infection. (D-E) As panel A/C, respectively, using proteins upregulated by ‘sensitive’ criteria (S6C Table).