SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2
Fig 3
TNF-α-producing T cells have the highest proportion of Ki-67 expression.
The percentages of Ki67 expressing SARS-CoV-2-specific CD4+ (left panels) and CD8+ (right panels) T cells obtained from the blood of PASC participants are shown. SARS-CoV-2 S- (top panel), N- (middle panel) and M- (bottom panel) specific T cells are grouped by production of IFN-γ, TNF-α and IL-2. Note, data points from individual PASC participants were obtained for 1 or more of the cytokines assessed; however, in no instances are there multiple values obtained from the same participant for a particular cytokine. Blue represents IFN-γ+ T cells, brown represents TNF-α+ T cells and green represents IL-2+ T cells. Kruskal-Wallis tests with corrections for multiple comparisons were used to determine statistical significance.