Curcumin activation of a bacterial mechanosensitive channel underlies its membrane permeability and adjuvant properties
Fig 6
Curcumin antibiotic synergy is MscL-dependent but RecA-independent.
Shown are the E. coli Stains PB112 (ΔrecA, ΔMscL, ΔMscS) and MJF455 (ΔMscL, ΔMscS) carrying vector only (No MscL) or expressing MscL (MscL), treated with 0.25 μM kanamycin (yellow), 100 μM curcumin (blue), or a combination of the two (green). A) Inhibition of growth (OD600) treated as indicated, expressed as the percentage change of the untreated. n = 4, Statistics reflect a comparison of MscL-expressing versus “no MscL” strains ***P < 0.0005 as indicated, 2-tailed t-test.